Expression of Multidrug Resistance-Associated Protein (MRP) in Brain Microvessel Endothelial Cells

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

1996 • 569 citations

Tissue distribution of the multidrug resistance protein.

1996 • 473 citations

Biology of the multidrug resistance-associated protein, MRP

1996 • 367 citations

Implications of the Blood-Brain Barrier and Its Manipulation

1989 • 308 citations

Transport properties of the multidrug resistance‐associated protein (MRP) in human tumour cells

1996 • 194 citations

Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy.

1991 • 160 citations

Indomethacin-mediated reversal of multidrug resistance and drug efflux in human and murine cell lines overexpressing MRP, but not P-glycoprotein

1997 • 138 citations

Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers

1996 • 135 citations

Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter.

1996 • 108 citations

Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis.

1993 • 104 citations

Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells.

1992 • 99 citations

Effect of the P-Glycoprotein Inhibitor, Cyclosporine A, on the Distribution of Rhodamine-123 to the Brain: An in Vivo Microdialysis Study in Freely Moving Rats

1995 • 83 citations

Application of cultured endothelial cells of the brain microvasculature in the study of the blood-brain barrier

1992 • 81 citations

Study on brain interstitial fluid distribution and blood-brain barrier transport of baclofen in rats by microdialysis.

1995 • 80 citations

Multidrug resistance-associated protein: A protein distinct from P-glycoprotein involved in cytotoxic drug expulsion

1997 • 78 citations

Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: possible involvement of the monocarboxylic acid transport system.

1997 • 75 citations

The expression of multidrug resistance-associated protein (MRP) in pancreatic adenocarcinoma cell lines

1996 • 67 citations

Expression of multidrug-resistance-associated protein (MRP) and chemosensitivity in human gastric cancer

1996 • 49 citations

Aluminum citrate is transported from brain into blood via the monocar☐ylic acid transporter located at the blood-brain barrier

1997 • 40 citations

The multidrug transporters—proteins of an ancient immune system

1996 • 33 citations

Effect of para-aminohippurate on the efflux of valproic acid from the central nervous system of the rabbit

1996 • 15 citations

How chronically administered valproate increases chlordiazepoxide transfer through the blood‐brain barrier

1990 • 7 citations