Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation.

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Poly(ADP-Ribose) in the Cellular Response to DNA Damage

1985 • 771 citations

Preparation of adsorbents for biospecific affinity chromatography

1974 • 670 citations

Death and the cell

1986 • 616 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Apoptosis: a different type of cell death

1992 • 523 citations

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

1989 • 501 citations

Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.

1990 • 489 citations

Patterns of cell death.

1988 • 470 citations

Interleukin 1 is processed and released during apoptosis.

1991 • 459 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1992 • 379 citations

IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.

1991 • 324 citations

DNA strand breaks, NAD metabolism, and programmed cell death

1986 • 303 citations

Inhibition of DNA Fragmentation in Thymocytes and Isolated Thymocyte Nuclei by Agents That Stimulate Protein Kinase C

1989 • 276 citations

Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells.

1993 • 198 citations

Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.

1992 • 195 citations

Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation.

1989 • 194 citations

Inhibition of apoptosis as a mechanism of tumor promotion

1994 • 192 citations

Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells.

1991 • 189 citations

Protection from tumor necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2.

1991 • 189 citations

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

1989 • 186 citations

Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.

1991 • 185 citations

Nicotine inhibition of apoptosis suggests a role in tumor promotion

1993 • 177 citations

Activation of a Ca²⁺−Mg²⁺‐dependent endonuclease as an early event in castration‐induced prostatic cell death

1988 • 176 citations

Apoptosis and DNA fragmentation precede TNF‐induced cytolysis in U937 cells

1992 • 146 citations

Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s).

1990 • 134 citations

Elastase of U-937 Monocytelike Cells

1982 • 126 citations

Tumor necrosis factor-mediated cytotoxicity involves ADP-ribosylation.

1988 • 113 citations

The Isolation and Characterization of a Family of Serine Protease Genes Expressed in Activated Cytotoxic T Lymphocytes

1988 • 95 citations

Phorbol esters inhibit apoptosis in IL-2-dependent T lymphocytes

1989 • 95 citations

Acylamido boronic acids and difluoroborane analogs of amino acids: potent inhibitors of chymotrypsin and elastase

1985 • 87 citations

Inhibitors of proteases prevent endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes.

1992 • 86 citations

Protection from tumor necrosis factor cytotoxicity by protease inhibitors

1987 • 75 citations

Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases.

1992 • 75 citations

NK cell‐induced cytotoxicity is dependent on a Ca²⁺ increase in the target

1990 • 73 citations

Involvement of a serine protease in tumour‐necrosis‐factor‐mediated cytotoxicity

1988 • 65 citations

Granzymes: a Family of Serine Proteases in Granules of Cytolytic T Lymphocytes

1988 • 50 citations

Epidermal Growth Factor and tumor promoters prevent DNA fragmentation by different mechanisms

1984 • 49 citations

Role of protein phosphorylation in TNF‐induced apoptosis: Phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF‐resistant U937 variants

1993 • 38 citations

Calcium-independent pathway of tumor necrosis factor-mediated lysis of target cells.

1989 • 34 citations

Potential intracellular target proteins of the anticarcinogenic Bowman Birk protease inhibitor identified by affinity chromatography.

1988 • 33 citations

Induction of programmed cell death (apoptosis) in mature lymphocytes

1991 • 32 citations

Symposium cellular response to DNA damage the role of poly(ADP-ribose) poly(ADP-ribose) in the cellular response to DNA damage

1985 • 26 citations

Antimetastatic activity of boro-amino acid analog protease inhibitors against B16BL6 melanoma in vivo.

1992 • 19 citations