High-Grade Astrocytomas

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas

1978 • 1,663 citations

Randomized Comparisons of Radiotherapy and Nitrosoureas for the Treatment of Malignant Glioma after Surgery

1980 • 1,625 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas

1995 • 1,359 citations

Recursive Partitioning Analysis of Prognostic Factors in Three Radiation Therapy Oncology Group Malignant Glioma Trials

1993 • 1,311 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

1991 • 994 citations

Assumptions in the radiotherapy of glioblastoma

1980 • 987 citations

Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings.

1994 • 907 citations

Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults

1993 • 872 citations

An analysis of dose-effect relationship in the radiotherapy of malignant gliomas

1979 • 850 citations

Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma

1989 • 772 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology.

1993 • 534 citations

Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: Results of three consecutive radiation therapy oncology group (RTOG) clinical trials

1993 • 527 citations

Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.

1994 • 483 citations

Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms.

1993 • 467 citations

In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.

1993 • 442 citations

Stereotactic Histologic Correlations of Computed Tomography- and Magnetic Resonance Imaging-Defined Abnormalities in Patients With Glial Neoplasms

1987 • 404 citations

Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarrazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report

1990 • 399 citations

Treatment and Prevention of Rat Glioblastoma by Immunogenic C6 Cells Expressing Antisense Insulin-Like Growth Factor I RNA

1993 • 328 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors

1994 • 304 citations

The role of surgery in the management of supratentorial intermediate and high-grade astrocytomas in adults

1990 • 303 citations

The p53 Gene and Protein in Human Brain Tumors

1994 • 303 citations

p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.

1992 • 297 citations

Supratentorial malignant glioma: Patterns of recurrence and implications for external beam local treatment

1992 • 290 citations

Temozolomide: A new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours

1993 • 276 citations

The prognostic importance of tumor size in malignant gliomas: a computed tomographic scan study by the Brain Tumor Cooperative Group.

1988 • 273 citations

Increasing Annual Incidence of Primary Malignant Brain Tumors in the Elderly

1990 • 266 citations

Experimental and Clinical Studies of Cytokine Gene-Modified Tumor Cells

1994 • 259 citations

Radiosurgery as part of the initial management of patients with malignant gliomas.

1992 • 255 citations

Occupational exposure to electromagnetic fields in relation to leukemia and brain tumors: a case-control study in Sweden

1993 • 254 citations

Reoperation for Recurrent Glioblastoma and Anaplastic Astrocytoma

1987 • 250 citations

A randomized comparison of intra-arterial versus intravenous with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma

1992 • 241 citations

The trends in incidence of primary brain tumors in the population of rochester, minnesota

1995 • 240 citations

The retinoblastoma gene is involved in malignant progression of astrocytomas

1994 • 220 citations

PET of malignant cerebral tumors after interstitial brachytherapy

1988 • 216 citations

Survival and quality of life after interstitial implantation of removable high-activity iodine-125 sources for the treatment of patients with recurrent malignant gliomas

1989 • 216 citations

Recurrent malignant gliomas: survival following interstitial brachytherapy with high-activity iodine-125 sources

1987 • 213 citations

High activity iodine-125 interstitial implant for gliomas

1992 • 208 citations

External irradiation followed by an interstitial high activity iodine-125 implant “boost” in the initial treatment of malignant gliomas: NCOG study 6G-82-2 gliomas: NCOG study 6H-82-2

1991 • 193 citations

Differentiation of Cerebral Radiation Necrosis from Tumor Recurrence by [18F]FDG and 82Rb Positron Emission Tomography

1987 • 185 citations

Identification of early recurrence of primary central nervous system tumors by [¹⁸F]fluorodeoxyglucose positron emission tomography

1991 • 174 citations

A prospective study of short-course radiotherapy in poor prognosis glioblastoma multiforme

1994 • 168 citations

Correlation of basic fibroblast growth factor expression levels with the degree of malignancy and vascularity in human gliomas

1992 • 166 citations

Hyperfractionated radiation therapy and bis-chlorethyl nitrosourea in the treatment of malignant glioma—Possible advantage observed at 72.0 Gy in 1.2 Gy B.I.D. fractions: Report of the radiation therapy oncology group protocol 8302

1993 • 163 citations

Cognitive functioning in long-term survivors of high-grade glioma

1994 • 161 citations

Complications of therapy for venous thromboembolic disease in patients with brain tumors

1993 • 158 citations

Intracarotid infusion of RMP-7, a bradykinin analog: a method for selective drug delivery to brain tumors

1994 • 158 citations

Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours

1990 • 158 citations

Correlates of survival and the Daumas-Duport grading system for astrocytomas

1991 • 157 citations

Selection bias, survival, and brachytherapy for glioma

1992 • 154 citations

Gene therapy for cancer

1992 • 154 citations

A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer.

1994 • 154 citations

Absence of contrast enhancement on CT brain scans of patients with supratentorial malignant gliomas

1988 • 153 citations

Clinical and Radiographic Response in a Minority of Patients with Recurrent Malignant Gliomas Treated with High-Dose Tamoxifen

1993 • 152 citations

Treatment of glioma by engineered interleukin 4-secreting cells.

1993 • 149 citations

Proliferating cell nuclear antigen and Ki-67 immunohistochemistry in brain tumors: A comparative study

1991 • 148 citations

Stereotactic radiosurgery for glioblastoma multiforme: Report of a prospective study evaluating prognostic factors and analyzing long-term survival advantage

1994 • 147 citations

Malignant astrocytomas treated with iodine-125 labeled monoclonal antibody 425 against epidermal growth factor receptor: A phase II trial

1992 • 147 citations

Oncology of the Nervous System

1983 • 146 citations

Do prophylactic anticonvulsant drugs alter the pattern of seizures after craniotomy?

1992 • 142 citations

Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas

1991 • 142 citations

Clinical application of PET for the evaluation of brain tumors.

1991 • 141 citations

Results of Stereotactic Brachytherapy Used in the Initial Management of Patients With Glioblastoma

1990 • 141 citations

Treatment of neuroectodermal brain tumors

1982 • 141 citations

The basis for current treatment recommendations for malignant gliomas

1994 • 135 citations

Increasing Incidence of Primary Malignant Brain Tumors: Influence of Diagnostic Methods

1992 • 131 citations

Correlation between the bromodeoxyuridine labeling index and the MIB-1 and Ki-67 proliferating cell indices in cerebral gliomas

1994 • 125 citations

Osmotic blood-brain barrier disruption and chemotherapy in the treatment of high grade malignant glioma: patient series and literature review

1992 • 123 citations

Postoperative contrast enhancement in patients with brain tumor

1985 • 122 citations

Long term results of stereotactic brachytherapy used in the initial treatment of patients with glioblastomas

1994 • 122 citations

Stereotactic radiotherapy for pediatric and adult brain tumors: Preliminary report

1994 • 121 citations

Environmental risk factors for primary malignant brain tumors: A review

1993 • 118 citations

Contemporary approaches to the treatment of malignant gliomas with radiation therapy.

1994 • 117 citations

Survival comparison of radiosurgery-eligible and -ineligible malignant glioma patients treated with hyperfractionated radiation therapy and carmustine: a report of Radiation Therapy Oncology Group 83-02.

1993 • 113 citations

Detection of recurrent gliomas with quantitative thallium-201/technetium-99m HMPAO single-photon emission computerized tomography

1992 • 106 citations

Corticosteroid-induced magnetic resonance imaging changes in patients with recurrent malignant glioma.

1994 • 104 citations

Steroid‐induced CT changes in patients with recurrent malignant glioma

1988 • 100 citations

The genesis of peritumoral vasogenic brain edema and tumor cysts: a hypothetical role for tumor-derived vascular permeability factor.

1993 • 95 citations

Intravenous recombinant interferon beta in patients with recurrent malignant gliomas: a phase I/II study.

1991 • 89 citations

Gene transfer technologies for the gene therapy of cancer.

1994 • 85 citations

The chemotherapy of high-grade astrocytomas.

1994 • 78 citations

In VivoReplication-Deficient Adenovirus Vector-Mediated Transduction of the Cytosine Deaminase Gene Sensitizes Glioma Cells to 5-Fluorocytosine

1996 • 77 citations

The role of anticonvulsant medications in the management of patients with anaplastic gliomas

1981 • 77 citations

Postoperative Prophylactic Anticonvulsant Therapy in Cerebral Gliomas

1985 • 75 citations

Prognostic significance of the proliferative potential of intracranial gliomas measured by bromodeoxyuridine labeling

1993 • 73 citations

Diagnosis and management of gliomatosis cerebri: Recent trends

1991 • 72 citations

Selective Destruction of Gliomas in Immunocompetent Rats by Thymidine Kinase-Defective Herpes Simplex Virus Type 1

1994 • 72 citations

Pleomorphic xanthoastrocytoma

1989 • 71 citations

Malignant astrocytomas: surgical aspects.

1994 • 64 citations

Dominant-negative mutants of a platelet-derived growth factor gene.

1990 • 63 citations

Selective blood-tumor barrier disruption by leukotrienes

1992 • 62 citations

National cancer institute (phase II) study of high-grade glioma treated with accelerated hyperfractionated radiation and iododeoxyuridine: Results in anaplastic astrocytoma

1994 • 62 citations

Radiation Oncology: Technology and Biology

1995 • 60 citations

Interstitial irradiation versus interstitial thermoradiotherapy for supratentorial malignant gliomas: A comparative survival analysis

1994 • 58 citations

Clinical effect of intra-arterial tumor necrosis factor-α for malignant glioma

1992 • 57 citations

Long-term follow-up on National Cancer Institute Phase I/II study of glioblastoma multiforme treated with iododeoxyuridine and hyperfractionated irradiation.

1992 • 57 citations

Boron neutron capture therapy of primary and metastatic brain tumors

1994 • 53 citations

Epilepsy and other factors in the prognosis of gliomas

2009 • 50 citations

Neurobiology of brain tumors

1991 • 49 citations

Evaluation of prognostic factors in chemotherapy of recurrent brain tumors.

1983 • 47 citations

Growth inhibition, tumor maturation, and extended survival in experimental brain tumors in rats treated with phenylacetate.

1994 • 44 citations

Molecular genetics of human glioma

1995 • 38 citations

Immunotherapy of malignant gliomas.

1994 • 38 citations

Malignant glioma—timing of response to radiation therapy

1993 • 34 citations

Brachytherapy and hyperthermia for malignant astrocytomas.

1994 • 32 citations

High-dose chemotherapy with autologous bone marrow transplantation in the treatment of high grade astrocytomas in adults: therapeutic rationale and clinical experience.

1992 • 32 citations

Occupational exposure and brain tumors

1985 • 30 citations

The molecular biology and molecular genetics of astrocytic neoplasms.

1994 • 30 citations

Time Trends in Incidence of Brain and Central Nervous System Cancers in Connecticut

1991 • 28 citations

Radiosurgery/Stereotactic External Beam Radiotherapy for Malignant Brain Tumours: The Royal Marsden Hospital Experience

1994 • 27 citations

New Delivery Systems for Brain Tumor Therapy

1995 • 26 citations

The management of malignant gliomas with radiation therapy: Therapeutic results and research strategies

1991 • 25 citations

Advances in Chemotherapy for Brain Tumors

1995 • 25 citations

Gliomas in Families

1992 • 22 citations

Radiosurgery for intracranial malignancies

1995 • 22 citations

Radiosensitization with carotid intra‐arterial bromodeoxyuridine ± 5‐fluorouracil biomodulation for malignant gliomas

1994 • 20 citations

Astrocytomas: Diagnosis, treatment and biology

1993 • 19 citations

Chemotherapy of malignant gliomas: studies of the BTCG.

1992 • 17 citations

Neurological Complications of Cancer Treatment

1992 • 16 citations

5 GLIOBLASTOMA MULTIFORME AND ANAPLASTIC ASTROCYTOMA

1983 • 15 citations

Treatment strategies for patients with recurrent brain tumors

1991 • 15 citations

Radiation treatment planning for malignant astrocytomas

1991 • 14 citations

Chemotherapy and immunotherapy in adult malignant gliomas

1993 • 14 citations

RADIOLOGIC DIAGNOSIS, STAGING, AND FOLLOW-UP OF ADULT CENTRAL NERVOUS SYSTEM PRIMARY MALIGNANT GLIOMA

1994 • 13 citations

AGM-1470 Inhibits the Growth of Human Glioblastoma Cells in Vitro and in Vivo

1994 • 10 citations

The role of cytoreductive surgery in the treatment of intracranial gliomas

1991 • 8 citations

Adjuvant chemotherapy for brain tumor

1991 • 4 citations