The genesis of peritumoral vasogenic brain edema and tumor cysts: a hypothetical role for tumor-derived vascular permeability factor.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Angiogenic Factors

1987 • 3,702 citations

JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN

1969 • 2,408 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas

1978 • 1,663 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

STUDIES ON INFLAMMATION

1961 • 1,539 citations

The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA

1991 • 1,375 citations

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

1989 • 1,282 citations

Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein.

1984 • 1,249 citations

Presidential Address^*

1967 • 1,183 citations

NEW CYTOPLASMIC COMPONENTS IN ARTERIAL ENDOTHELIA

1964 • 1,062 citations

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

1984 • 937 citations

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

1980 • 925 citations

Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths

1985 • 660 citations

A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines.

1986 • 641 citations

Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone

1983 • 622 citations

The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat

1977 • 596 citations

Protamine is an inhibitor of angiogenesis

1982 • 582 citations

Culture of vascular endothelium.

1976 • 532 citations

Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.

1990 • 503 citations

The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.

1992 • 495 citations

Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

1992 • 443 citations

Fura-2 measurement of cytosolic free Ca2+ in monolayers and suspensions of various types of animal cells.

1987 • 424 citations

Brain Edema

1975 • 407 citations

Macrophage plasminogen activator: Modulation of enzyme production by anti-inflammatory steroids, mitotic inhibitors, and cyclic nucleotides

1976 • 405 citations

The blood-brain barrier to proteins under normal and pathological conditions

1970 • 402 citations

Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate.

1976 • 400 citations

Capillary Ultrastructure and the Blood-Brain Barrier in Human Malignant Brain Tumors

1970 • 371 citations

Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.

1992 • 355 citations

Effects of Dexamethasone in Primary Supratentorial Intracerebral Hemorrhage

1987 • 345 citations

Role of endothelial cell cytoskeleton in control of endothelial permeability.

1982 • 310 citations

Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers.

1986 • 289 citations

The blood-retinal barriers

1976 • 273 citations

Isolation and Culture of Pulmonary Artery Endothelial Cells

1978 • 265 citations

Endothelial Cells and the Biology of Factor VIII

1977 • 252 citations

Reoperation for Recurrent Glioblastoma and Anaplastic Astrocytoma

1987 • 250 citations

Radiation therapy of brain tumors

1977 • 249 citations

Vascular structures in brain tumors

1975 • 239 citations

Primary culture of capillary endothelium from rat brain

1981 • 234 citations

Glioblastoma Multiforme

1958 • 213 citations

Use of dexamethasone in the treatment of cerebral edema resulting from brain tumors and brain surgery.

1961 • 206 citations

Factors influencing endothelial cell proliferation in vitro

1978 • 205 citations

On the Mechanism of Vascular Leakage Caused by Histamine-Type Mediators

1967 • 201 citations

Exogenous ATP raises cytoplasmic free calcium in fura‐2 loaded piglet aortic endothelial cells

1986 • 200 citations

Methods for microcarrier culture of bovine pulmonary artery endothelial cells avoiding the use of enzymes

1980 • 180 citations

Structural basis of permeability in sequential segments of the microvasculature of the diaphragm

1978 • 175 citations

AIDS-associated kaposi's sarcoma cells in culture express vascular endothelial growth factor

1992 • 164 citations

Capillary ultrastructure in human metastatic brain tumors

1979 • 156 citations

Leukotrienes increase blood‐brain barrier permeability following intraparenchymal injections in rats

1985 • 155 citations

Failure of high-dose steroid therapy to influence intracranial pressure in patients with severe head injury

1979 • 151 citations

TREATMENT OF CEREBRAL METASTASES FROM BREAST CARCINOMA WITH PREDNISOLONE

1957 • 149 citations

Calcium channels and calcium channel antagonists

1987 • 141 citations

Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C.

1992 • 135 citations

Peritumoral Brain Edema in Meningiomas–Influence of Vascular Supply on Its Development

1992 • 126 citations

VASOGENIC BRAIN OEDEMA: New aspects in its formation, resolution and therapy

1976 • 120 citations

Vascular permeability induced by protein product of malignant brain tumors: inhibition by dexamethasone

1987 • 120 citations

Cerebral Edema Associated with Meningiomas: Possible Role of a Secretory-Excretory Phenomenon

1984 • 119 citations

Thrombin and histamine activate phospholipase C in human endothelial cells via a phorbol ester‐sensitive pathway

1988 • 117 citations

Vascular endothelial cell growth factor (VEGF) produced by A-431 human epidermoid carcinoma cells and identification of VEGF membrane binding sites.

1991 • 115 citations

The role of arachidonic acid in vasogenic brain edema.

1984 • 111 citations

Glomerular charge and urinary protein excretion: Effects of systemic and intrarenal polycation infusion in the rat

1982 • 109 citations

Further characterization of malignant glioma-derived vascular permeability factor

1988 • 107 citations

Positron emission tomographic measurement of blood‐to‐brain and blood‐to‐tumor transport of ⁸²Rb: The effect of dexamethasone and whole‐brain radiation therapy

1985 • 107 citations

The kallikrein-kinin system as mediator in vasogenic brain edema

1984 • 105 citations

SUBTEMPORAL DECOMPRESSIVE OPERATIONS FOR THE INTRACRANIAL COMPLICATIONS ASSOCIATED WITH BURSTING FRACTURES OF THE SKULL

1908 • 103 citations

Conditioned Medium from Mouse Sarcoma 180 Cells Contains Vascular Endothelial Growth Factor

1990 • 101 citations

Purification and cloning of vascular endothelial growth factor secreted by pituitary folliculostellate cells

1991 • 99 citations

Brain- and liver cell-derived factors are required for growth of human endothelial cells in serum-free culture.

1984 • 91 citations

Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model

1986 • 90 citations

Specific binding of vascular permeability factor to endothelial cells

1991 • 86 citations

Angiogenesis and Neoplastic Progression In Vitro<xref ref-type="fn" rid="fn2">2</xref>

1982 • 86 citations

Inhibition of angiogenesis and growth of human nerve-sheath tumors by AGM-1470

1993 • 85 citations

Quantitative autoradiographic measurements of blood-brain barrier permeability in the rat glioma model

1982 • 83 citations

Vascular ultrastructure in human meningiomas and schwannomas

1973 • 82 citations

The response of human cerebral edema to glucosteroid administration

1966 • 79 citations

In vitro plasminogen activator activity in human brain tumors.

1978 • 77 citations

The ultrastructure and permeability characteristics of the blood vessels of a transplantable rat sarcoma

1972 • 75 citations

The effects of polycations on vascular permeability in the rat. A proposed role for charge sites.

1984 • 75 citations

EVALUATION OF THE ROLE OF HISTAMINE H₁AND H₂‐RECEPTORS IN CUTANEOUS INFLAMMATION IN THE GUINEA‐PIG PRODUCED BY HISTAMINE AND MAST CELL DEGRANULATION

1980 • 74 citations

Capillary junctions of the rat are not affected by osmotic opening of the blood-brain barrier

1984 • 69 citations

Effects of dexamethasone on tumor-induced brain edema and its distribution in the brain of monkeys

1979 • 69 citations

Oxygen Free Radicals in the Genesis of Traumatic and Peritumoral Brain Edema

1989 • 66 citations

Cytosolic calcium changes in endothelial cells induced by a protein product of human gliomas containing vascular permeability factor activity

1989 • 61 citations

The effect of dexamethasone on serum protein extravasation and edema development in experimental brain tumors of cat

1983 • 58 citations

A study of glucocorticoid receptors in intracranial tumors

1981 • 57 citations

Interaction of gangliosides with fibronectin in the mobilization of capillary endothelium. Possible influence on the growth of metastasis.

1986 • 56 citations

Endothelial fenestrations and other vascular alterations in primary melanoma of the central nervous system

1974 • 55 citations

Megadose corticosteroid therapy following experimental traumatic spinal injury

1984 • 54 citations

The Pathogenesis of Cerebral Gliomatous Cysts

1992 • 50 citations

Intracarotid infusions of protamine sulfate disrupt the blood-brain barrier of rabbits

1987 • 47 citations

Calcium ionophore (A23187)- and arachidonic acid-stimulated prostaglandin release from microvascular endothelial cells: effects of calcium antagonists and calmodulin inhibitors.

1987 • 46 citations

Effect of Dexamethasone Treatment on Peritumoral Brain Edema

1982 • 46 citations

Polyamine and Prostaglandin Markers in Focal Cerebral Ischemia

1985 • 45 citations

Transport of hexoses, potassium and neutral amino acids into capillaries isolated from bovine retina

1980 • 44 citations

Inhibition of growth and angiogenesis of human neurofibrosarcoma by heparin and hydrocortisone

1990 • 40 citations

Hormone Binding in Brain Tumors

1983 • 40 citations

Comparative Study of Different Iron-Chelating Agents in Cold-Induced Brain Edema

1989 • 39 citations

Actinomycin D suppresses the protective effect of dexamethasone in rats affected by global cerebral ischemia.

1985 • 37 citations

Formation and propagation of brain oedema fluid around human brain metastases. A CT study

1988 • 36 citations

Eicosanoid production by the coronary microvascular endothelium.

1987 • 33 citations

Studies on the capillary permeability of experimental liver metastases.

1978 • 31 citations

The management of cerebral oedema

1984 • 28 citations

Correlation of tumor plasminogen activator with peritumoral cerebral edema

1987 • 26 citations

Characterization of a protein product of human malignant glial tumors that induces microvascular permeability.

1990 • 24 citations

Determination of the glial fibrillary acidic protein in human cerebrospinal fluid and in cyst fluid of brain tumors

1986 • 23 citations

Steroid Receptors in Human Brain and Spinal Cord Tumors

1988 • 23 citations

Polyamine metabolism and polyamine excretion in normal and tumor bearing rodents.

1985 • 22 citations

(68Ga)-EDTA positron emission tomography in the diagnosis of brain tumors

1984 • 21 citations

Modification of Tumor Enhancement and Brain Edema in Computerized Tomography by Corticosteroids

1980 • 20 citations

Changes of vascular endothelial cell shape and of membrane potential in response to the ionophore A23187.

1987 • 14 citations

Mechanism of ionophore A23187 induction of plasma protein leakage and of its inhibition by indomethacin

1982 • 7 citations

A permeability-enhancing factor produced by tumor

1980 • 7 citations

Vasogenic edema with intraparenchymatous expanding mass lesions: A theory on its pathophysiology and mode of action of hyperventilation and corticosteroids

1984 • 7 citations

CT findings and glucocorticoid receptors in intracranial lesions with edema.

1981 • 5 citations

Vascular permeability-increasing action of hypoalbuminemic substance from Ehrlich ascites carcinoma cells.

1975 • 4 citations