CD4-Induced Conformational Changes in the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein: Consequences for Virus Entry and Neutralization

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS

1984 • 3,647 citations

Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS

1984 • 3,566 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

1996 • 2,735 citations

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

1996 • 2,326 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

Core Structure of gp41 from the HIV Envelope Glycoprotein

1997 • 1,904 citations

Atomic structure of the ectodomain from HIV-1 gp41

1997 • 1,610 citations

Structure of influenza haemagglutinin at the pH of membrane fusion

1994 • 1,546 citations

THE STRUCTURE AND FUNCTION OF THE HEMAGGLUTININ MEMBRANE GLYCOPROTEIN OF INFLUENZA VIRUS

1987 • 1,391 citations

CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5

1996 • 1,181 citations

Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

1996 • 1,111 citations

CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5

1996 • 1,058 citations

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

1997 • 923 citations

CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4

1996 • 669 citations

Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

1989 • 662 citations

Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

1993 • 636 citations

Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

1988 • 621 citations

Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4

1990 • 598 citations

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.

1991 • 598 citations

Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates

1988 • 443 citations

Detection of a fusion peptide sequence in the transmembrane protein of human immunodeficiency virus

1987 • 433 citations

Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding

1995 • 414 citations

Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120

1995 • 405 citations

A General Model for the Transmembrane Proteins of HIV and Other Retroviruses

1989 • 375 citations

Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry

1996 • 365 citations

Human immunodeficiency virus type 1 neutralization is determined by epitope exposure on the gp120 oligomer.

1995 • 334 citations

Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding

1993 • 320 citations

Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein

1996 • 307 citations

Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates

1995 • 293 citations

Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates

1992 • 287 citations

Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants

1990 • 268 citations

Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody

1991 • 265 citations

Efficient Interaction of HIV-1 with Purified Dendritic Cells via Multiple Chemokine Coreceptors

1996 • 245 citations

Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex

1997 • 230 citations

HIV infection does not require endocytosis of its receptor, CD4

1988 • 228 citations

Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

1991 • 211 citations

Epitope exposure on functional, oligomeric HIV-1 gp41 molecules

1995 • 189 citations

Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4

1991 • 178 citations

Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4

1992 • 173 citations

Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120

1993 • 143 citations

Replicative capacity, cytopathic effect and cell tropism of HIV

1989 • 137 citations

Enhancement of SIV Infection with Soluble Receptor Molecules

1990 • 136 citations

Probing the structure of the V2 domain of human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: human immune response to the V1 and V2 domains

1993 • 124 citations

Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion

1990 • 124 citations

Epitope map of human immunodeficiency virus type 1 gp41 derived from 47 monoclonal antibodies produced by immunization with oligomeric envelope protein

1997 • 105 citations

Human monoclonal antibody that recognizes the V3 region of human immunodeficiency virus gp120 and neutralizes the human T-lymphotropic virus type IIIMN strain.

1990 • 104 citations

Target cell-specific determinants of membrane fusion within the human immunodeficiency virus type 1 gp120 third variable region and gp41 amino terminus

1992 • 101 citations

Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events

1992 • 87 citations

Identification of Conserved and Variant Epitopes of Human Immunodeficiency Virus Type 1 (HIV-1) gp120 by Human Monoclonal Antibodies Produced by EBV-Transformed Cell Lines

1990 • 79 citations

Increase in soluble CD4 binding to and CD4-induced dissociation of gp120 from virions correlates with infectivity of human immunodeficiency virus type 1

1994 • 77 citations

Enhancement of Infectivity of a Non‐Syncytium Inducing HIV‐1 by sCD4 and by Human Antibodies that Neutralize Syncytium Inducing HIV‐1

1995 • 74 citations

Physicochemical dissociation of CD4-mediated syncytium formation and shedding of human immunodeficiency virus type 1 gp120

1993 • 73 citations

Mutations in human immunodeficiency virus type 1 gp41 affect sensitivity to neutralization by gp120 antibodies

1993 • 64 citations

The Construction and Use of a Human-Mouse Myeloma Analogue Suitable for the Routine Production of Hybridomas Secreting Human Monoclonal Antibodies

1987 • 63 citations

Membrane Fusion by Influenza Hemagglutinin

1995 • 62 citations

Thermodynamic and Kinetic Analysis of sCD4 Binding to HIV-1 Virions and of gp120 Dissociation

1992 • 57 citations

HIV binding to its receptor creates specific epitopes for the CD4/gp120 complex

1993 • 56 citations

Macrophage-tropic and T-cell line-adapted chimeric strains of human immunodeficiency virus type 1 differ in their susceptibilities to neutralization by soluble CD4 at different temperatures

1994 • 56 citations

The T4 Glycoprotein Is a Cell-surface Receptor for the AIDS Virus

1986 • 34 citations

Construction of a binding site for human immunodeficiency virus type 1 gp120 in rat CD4.

1992 • 31 citations

HIV-induced syncytium formation requires the formation of conjugates between virus-infected and uninfected T-cells in vitro

1991 • 27 citations

Strong Association of Simian Immunodeficiency Virus (SIVagm) Envelope Glycoprotein Heterodimers: Possible Role in Receptor-Mediated Activation

1992 • 23 citations

Enhancement of human immunodeficiency virus type 1 envelope-mediated fusion by a CD4-gp120 complex-specific monoclonal antibody

1997 • 23 citations

Conformational transitions in CD4 due to complexation with HIV envelope glycoprotein gp120.

1997 • 22 citations

Characterization of CD4-gp120 Activation Intermediates during Human Immunodeficiency Virus Type 1 Syncytium Formation

1996 • 14 citations

Role of CD4 in the Penetration of Cells by HIV

1991 • 12 citations

Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1

1997 • 11 citations

Conformation of the HIV-1 gp120 Envelope Glycoprotein

2015 • 6 citations