Characterization of CD4-gp120 Activation Intermediates during Human Immunodeficiency Virus Type 1 Syncytium Formation

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1

1987 • 883 citations

Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

1987 • 827 citations

Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

1993 • 636 citations

pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane

1987 • 620 citations

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.

1991 • 598 citations

Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4

1990 • 598 citations

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein

1986 • 593 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

AIDS Retrovirus Induced Cytopathology: Giant Cell Formation and Involvement of CD4 antigen

1986 • 516 citations

Adsorptive endocytosis of Semliki Forest virus

1980 • 354 citations

Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41.

1990 • 348 citations

Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding

1993 • 320 citations

Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism.

1988 • 299 citations

Identification of the Fusion Peptide of Primate Immunodeficiency Viruses

1989 • 250 citations

The V3 Loops of the HIV-1 and HTV-2 Surface Glycoproteins Contain Proteolytic Cleavage Sites: A Possible Function in Viral Fusion?

1991 • 244 citations

Tracking of cell surface receptors by fluorescence digital imaging microscopy using a charge-coupled device camera: Low-density lipoprotein and influenza virus receptor mobility at 4°C

1992 • 243 citations

Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

1991 • 211 citations

A Golgi retention signal in a membrane-spanning domain of coronavirus E1 protein.

1991 • 185 citations

Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4

1992 • 173 citations

Temperature dependence of the rate constants of the Escherichia coli RNA polymerase-λP promoter interaction

1985 • 162 citations

The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure.

1992 • 159 citations

Identification of a membrane fusion domain and an oligomerization domain in the baculovirus GP64 envelope fusion protein

1995 • 137 citations

A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells

1992 • 132 citations

Inhibition of HIV infection by a novel CD4 domain 2-specific monoclonal antibody. Dissecting the basis for its inhibitory effect on HIV-induced cell fusion.

1992 • 128 citations

Theoretical and functional analysis of the SIV fusion peptide.

1991 • 126 citations

The Block to HIV-1 Envelope Glycoprotein-Mediated Membrane Fusion in Animal Cells Expressing Human CD4 Can Be Overcome by a Human Cell Component(s)

1993 • 124 citations

Orientation and structure of the NH2-terminal HIV-1 gp41 peptide in fused and aggregated liposomes

1993 • 102 citations

Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity

1991 • 101 citations

Conformation-dependent platelet adhesion to collagen involving integrin alpha 2 beta 1-mediated and other mechanisms: multiple alpha 2 beta 1-recognition sites in collagen type I.

1994 • 100 citations

Evidence that the stalk of Drosophila kinesin heavy chain is an alpha-helical coiled coil.

1992 • 99 citations

Conformation of membrane fusion-active 20-residue peptides with or without lipid bilayers. Implication of .alpha.-helix formation for membrane fusion

1990 • 94 citations

Temperature dependence of cell-cell fusion induced by the envelope glycoprotein of human immunodeficiency virus type 1

1995 • 93 citations

The amino-terminal peptide of HIV-1 glycoprotein 41 interacts with human erythrocyte membranes: peptide conformation, orientation and aggregation

1992 • 90 citations

“Primatization” of Recombinant Antibodies for Immunotherapy of Human Diseases: A Macaque/Human Chimeric Antibody Against Human CD4

1992 • 88 citations

Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events

1992 • 87 citations

Fusogenic segments of bovine leukemia virus and simian immunodeficiency virus are interchangeable and mediate fusion by means of oblique insertion in the lipid bilayer of their target cells.

1992 • 86 citations

The role of CD4 in HIV binding and entry

1993 • 86 citations

Conformational stability and mechanism of folding of ribonuclease T1

1989 • 81 citations

A region in domain 1 of CD4 distinct from the primary gp120 binding site is involved in HIV infection and virus-mediated fusion.

1991 • 81 citations

Physicochemical dissociation of CD4-mediated syncytium formation and shedding of human immunodeficiency virus type 1 gp120

1993 • 73 citations

Quantitative measurement of fusion between human immunodeficiency virus and cultured cells using membrane fluorescence dequenching

1988 • 73 citations

Morphometric Analysis of Recombinant Soluble CD4-Mediated Release of the Envelope Glycoprotein gp120 from HIV-1

1990 • 72 citations

Kinetics and extent of fusion between Sendai virus and erythrocyte ghosts: application of a mass action kinetic model

1986 • 71 citations

Conformation of thymosin β₄ in water determined by NMR spectroscopy

1993 • 69 citations

A common mechanism for influenza virus fusion activity and inactivation

1993 • 68 citations

Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human immunodeficiency virus type 1 by soluble CD4 and CD4 peptide derivatives: implications for the role of the complementarity-determining region 3-like region in membrane fusion.

1991 • 63 citations

Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices

1994 • 63 citations

HIV interactions with CD4: a continuum of conformations and consequences

1992 • 58 citations

Thermodynamic and Kinetic Analysis of sCD4 Binding to HIV-1 Virions and of gp120 Dissociation

1992 • 57 citations

Determinants of human immunodeficiency virus type 1 envelope glycoprotein oligomeric structure

1995 • 56 citations

Calcium ions are required for cell fusion mediated by the CD4-human immunodeficiency virus type 1 envelope glycoprotein interaction

1993 • 53 citations

Human immunodeficiency virus type 1 envelope gp120 is cleaved after incubation with recombinant soluble CD4

1993 • 51 citations

Intercellular adhesion molecules (ICAM)‐1 ICAM‐2 and ICAM‐3 function as counter‐receptors for lymphocyte function‐associated molecule 1 in human immunodeficiency virus‐mediated syncytia formation

1994 • 51 citations

Investigation of Human Immunodeficiency Virus Fusion Peptides. Analysis of Interrelations Between Their Structure and Function

1992 • 50 citations

Kinetics of soluble CD4 binding to cells expressing human immunodeficiency virus type 1 envelope glycoprotein

1992 • 50 citations

Kinetics of HIV-1 interactions with sCD4 and CD4+ cells: Implications for inhibition of virus infection and initial steps of virus entry into cells

1992 • 48 citations

A Human Lymphoid Recombinant Cell Line with Functional Human Immunodeficiency Virus Type 1 Envelope

1993 • 47 citations

Conformational changes affecting the V3 and CD4-binding domains of human immunodeficiency virus type 1 gp120 associated with env processing and with binding of ligands to these sites

1993 • 40 citations

Diminution of CD4 surface protein but not CD4 messenger RNA levels in monocytic cells infected by HIV-1

1991 • 39 citations

Identification of a new neutralizing epitope conformationally affected by the attachment of CD4 to gp120.

1993 • 38 citations

Analysis of HIV-induced autoantibodies to cryptic epitopes on human CD4.

1992 • 34 citations

Detection of influenza hemagglutinin interaction with biological membranes by photosensitized activation of [125I]iodonaphthylazide.

1994 • 32 citations

High level of surface CD4 prevents stable human immunodeficiency virus infection of T-cell transfectants

1992 • 32 citations

The prevention of cell adhesion and the cell-to-cell spread of HIV-1 in vitro by the α-glucosidase 1 inhibitor, 6-O-butanoyl castanospermine (MDL 28574)

1994 • 31 citations

CD4 immunoadhesin, but not recombinant soluble CD4, blocks syncytium formation by human immunodeficiency virus type 2-infected lymphoid cells

1990 • 31 citations

Conformational rearrangements required of the V₃ loop of HIV‐1 gp120 for proteolytic cleavage and infection

1994 • 30 citations

Factors involved in entry of the human immunodeficiency virus type 1 into permissive cells: lack of evidence of a role for CD26

1994 • 29 citations

Kinetic modeling of Sendai virus fusion with PC‐12 cells

1992 • 26 citations

Adhesion Mediated by Intercellular Adhesion Molecule 1 Attenuates the Potency of Antibodies That Block HIV-1 gp160-Dependent Syncytium Formation

1994 • 26 citations

CD4 changes conformation upon ligand binding.

1992 • 25 citations

Strong Association of Simian Immunodeficiency Virus (SIVagm) Envelope Glycoprotein Heterodimers: Possible Role in Receptor-Mediated Activation

1992 • 23 citations

A highly selected panel of anti‐CD4 antibodies fails to induce anti‐idiotypic antisera mediating human immunodeficiency virus neutralization

1991 • 18 citations

LFA-1 Adhesion Molecules Are Not Involved in the Early Stages of HIV-1env-Mediated Cell Membrane Fusion

1992 • 15 citations

Localized Conformational Changes in the N-Terminal Domain of CD4 Identified in Competitive Binding Assay of Monoclonal Antibodies and HIV-1 Envelope Glycoprotein

1992 • 15 citations

Functional Epitope Analysis of the Human CD 11 a/CD 18 Molecule (LFA‐1, Lymphocyte Function‐Associated Antigen 1) Involved in HIV‐1‐Induced Syncytium Formation

1991 • 15 citations

Inhibitors of the Conformational Switch Involved in CD4 Binding by the env Glycoprotein gp120 from Human Immunodeficiency Virus Type 1 (HIV1)

1994 • 14 citations

Effect of an engineered disulfide bond on the folding of T4 lysozyme at low temperatures

1990 • 12 citations

Agonist-induced isomerization of the .alpha.1-adrenergic receptor: kinetic analysis using broken-cell and solubilized preparations

1986 • 12 citations

Temperature enhancement of syncytium formation by HIV and sendai virus

1992 • 6 citations

Conformation and stability of Sendai virus fusion protein

1989 • 2 citations