Peripheral neural targets in obesity

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

2003 • 7,305 citations

Biology of Incretins: GLP-1 and GIP

2007 • 3,315 citations

The Physiology of Glucagon-like Peptide 1

2007 • 2,882 citations

Gut hormone PYY3-36 physiologically inhibits food intake

2002 • 2,263 citations

Weight Gain as a Risk Factor for Clinical Diabetes Mellitus in Women

1995 • 2,099 citations

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

2003 • 2,083 citations

Obesity, Fat Distribution, and Weight Gain as Risk Factors for Clinical Diabetes in Men

1994 • 1,842 citations

Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans¹

2000 • 1,794 citations

Neuromorphic Silicon Neuron Circuits

2011 • 1,600 citations

Mammalian Sweet Taste Receptors

2001 • 1,550 citations

Inhibition of Food Intake in Obese Subjects by Peptide YY_3–36

2003 • 1,549 citations

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

2004 • 1,436 citations

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

2008 • 1,430 citations

An amino-acid taste receptor

2002 • 1,419 citations

Characteristics of the Cholecystokinin-Induced Depolarization of Pacemaking Activity in Cultured Interstitial Cells of Cajal from Murine Small Intestine

2013 • 1,378 citations

Human receptors for sweet and umami taste

2002 • 1,278 citations

The stomach is a source of leptin

1998 • 1,215 citations

Long-Term Persistence of Hormonal Adaptations to Weight Loss

2011 • 1,183 citations

Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin

2001 • 1,181 citations

Gastrointestinal regulation of food intake

2007 • 1,130 citations

The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats

2002 • 1,055 citations

Distribution of orexin neurons in the adult rat brain

1999 • 1,052 citations

The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids

2003 • 1,050 citations

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α

2003 • 1,007 citations

Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1

2007 • 931 citations

Inhibition of gastric inhibitory polypeptide signaling prevents obesity

2002 • 887 citations

T1R3 and gustducin in gut sense sugars to regulate expression of Na ⁺ -glucose cotransporter 1

2007 • 822 citations

Immunochemical studies on cholecystokinin. II. Distribution and molecular heterogeneity in the central nervous system and small intestine of man and hog.

1978 • 805 citations

Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction.

1985 • 733 citations

Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system

1999 • 733 citations

Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

2004 • 665 citations

Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents

2006 • 626 citations

Glucagon‐like peptide‐1 cells in the gastrointestinal tract and pancreas of rat, pig and man

1992 • 620 citations

Critical role for peptide YY in protein-mediated satiation and body-weight regulation

2006 • 596 citations

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4

1993 • 585 citations

The inhibitory effects of peripheral administration of peptide YY3–36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal–brainstem–hypothalamic pathway

2005 • 578 citations

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

2008 • 543 citations

Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells

1992 • 539 citations

Cellular localization of a metabotropic glutamate receptor in rat brain

1992 • 539 citations

Attenuated Peptide YY Release in Obese Subjects Is Associated with Reduced Satiety

2005 • 531 citations

Tension receptors in the stomach and the urinary bladder

1955 • 514 citations

Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat

1994 • 512 citations

Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids

2003 • 507 citations

Efficacy of Lifestyle Modification for Long‐Term Weight Control

2004 • 503 citations

<scp>l</scp> -Amino acid sensing by the extracellular Ca ²⁺ -sensing receptor

2000 • 484 citations

Bariatric Surgery: A Review of Procedures and Outcomes

2007 • 455 citations

Distribution of GLP‐1 Binding Sites in the Rat Brain: Evidence that Exendin‐4 is a Ligand of Brain GLP‐1 Binding Sites

1995 • 451 citations

Gastrointestinal hormones and food intake

2005 • 445 citations

Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine

2006 • 436 citations

Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2

2007 • 435 citations

Regulation of the Gastric Emptying of Glucose

1983 • 431 citations

Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms

1997 • 407 citations

The Role of the Vagal Nerve in Peripheral PYY3–36-Induced Feeding Reduction in Rats

2005 • 406 citations

Ghrelin: An orexigenic and somatotrophic signal from the stomach

2001 • 398 citations

Taste Preference for Fatty Acids Is Mediated by GPR40 and GPR120

2010 • 397 citations

Activation of Transient Receptor Potential Vanilloid Type-1 Channel Prevents Adipogenesis and Obesity

2007 • 385 citations

Metabolic Surgery to Treat Type 2 Diabetes: Clinical Outcomes and Mechanisms of Action

2010 • 377 citations

Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals.

1995 • 376 citations

Medium-chain Fatty Acids as Ligands for Orphan G Protein-coupled Receptor GPR84

2006 • 375 citations

Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats

1984 • 372 citations

The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity

2001 • 371 citations

Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats

1985 • 369 citations

Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells

2005 • 359 citations

Peptide YY3–36 and Glucagon-Like Peptide-17–36 Inhibit Food Intake Additively

2005 • 359 citations

Taste-Signaling Proteins Are Coexpressed in Solitary Intestinal Epithelial Cells

2006 • 353 citations

Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor

2004 • 344 citations

A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs

2003 • 344 citations

Orexin Synthesis and Response in the Gut

1999 • 329 citations

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

2010 • 312 citations

Leptin secretion and leptin receptor in the human stomach

2000 • 311 citations

Glucagon-Like Peptide-1 (GLP-1) Receptors Expressed on Nerve Terminals in the Portal Vein Mediate the Effects of Endogenous GLP-1 on Glucose Tolerance in Rats

2007 • 308 citations

The influence of psychological state and motivation on brain-computer interface performance in patients with amyotrophic lateral sclerosis - a longitudinal study

2010 • 308 citations

Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4

2011 • 307 citations

Expression of short-chain fatty acid receptor GPR41 in the human colon

2009 • 303 citations

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

2008 • 302 citations

A relation between the chain length of fatty acids and the slowing of gastric emptying

1968 • 301 citations

Covert expectation-of-reward in rat ventral striatum at decision points

2009 • 298 citations

Vagal glucoreceptors in the small intestine of the cat.

1978 • 294 citations

The “Normal” Endocrine Cell of the Gut: Changing Concepts and New Evidences

2004 • 292 citations

Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig

1996 • 291 citations

Evidence that Intestinal Glucagon-Like Peptide-1 Plays a Physiological Role in Satiety

2008 • 284 citations

Sweet Taste Receptor Expressed in Pancreatic β-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin Secretion

2009 • 282 citations

Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor

1999 • 276 citations

The role of peptide YY in appetite regulation and obesity

2008 • 276 citations

Seven evolutionarily conserved human rhodopsin G protein‐coupled receptors lacking close relatives

2003 • 275 citations

Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function

2005 • 272 citations

Vagal afferent responses to fatty acids of different chain length in the rat

2001 • 271 citations

3,5‐Dihydroxyphenylglycine Is a Highly Selective Agonist for Phosphoinositide‐Linked Metabotropic Glutamate Receptors in the Rat Hippocampus

1994 • 270 citations

Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure

2006 • 270 citations

Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells

2004 • 268 citations

A quantitative analysis of body mass index and colorectal cancer: findings from 56 observational studies

2009 • 267 citations

Sensory transmission in the gastrointestinal tract

2007 • 267 citations

Free fatty acids induce cholecystokinin secretion through GPR120

2007 • 265 citations

2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

2011 • 264 citations

The Taste of Monosodium Glutamate: Membrane Receptors in Taste Buds

1996 • 263 citations

Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility

1999 • 260 citations

Role of Leptin in the Regulation of Glucagon-Like Peptide-1 Secretion

2003 • 255 citations

Gastrointestinal mechanisms of satiation for food

2004 • 254 citations

Intraganglionic laminar endings are mechano‐transduction sites of vagal tension receptors in the guinea‐pig stomach

2001 • 254 citations

Glucagon gene expression in vertebrate brain.

1988 • 252 citations

Serotonin release and uptake in the gastrointestinal tract

2009 • 246 citations

Sweet taste signaling functions as a hypothalamic glucose sensor

2009 • 240 citations

Rapid development of tolerance to the behavioural actions of cholecystokinin

1983 • 240 citations

Gastric distension and gastric capacity in relation to food intake in humans

1988 • 240 citations

Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length

2004 • 232 citations

Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes

2006 • 230 citations

Gut chemosensing: Interactions between gut endocrine cells and visceral afferents

2009 • 228 citations

Retracted: Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat

2001 • 226 citations

Gut Vagal Afferents Are Not Necessary for the Eating-Stimulatory Effect of Intraperitoneally Injected Ghrelin in the Rat

2006 • 224 citations

Functional GIP Receptors Are Present on Adipocytes

1998 • 220 citations

Effects of cholecystokinin (CCK-8) on two classes of gastroduodenal vagal afferent fibre

1990 • 219 citations

Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans

2001 • 212 citations

Nutritional regulation of glucagon‐like peptide‐1 secretion

2008 • 203 citations

Vagal Mechanoreceptors and Chemoreceptors in Mouse Stomach and Esophagus

2002 • 203 citations

Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by in vivo DiI-tracing

1995 • 202 citations

Stimulation of Gastric Acid Secretion by Centrally Administered Orexin-A in Conscious Rats

1999 • 199 citations

Deorphanization of GPRC6A: A Promiscuous l-α-Amino Acid Receptor with Preference for Basic Amino Acids

2004 • 198 citations

GLP-1 and energy balance: an integrated model of short-term and long-term control

2011 • 198 citations

Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve

2001 • 195 citations

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

2003 • 192 citations

Caudal Brainstem Processing Is Sufficient for Behavioral, Sympathetic, and Parasympathetic Responses Driven by Peripheral and Hindbrain Glucagon-Like-Peptide-1 Receptor Stimulation

2008 • 191 citations

The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans

2000 • 190 citations

The electrophysiological identification of single nerve fibres, with particular reference to the slowest‐conducting vagal afferent fibres in the cat

1958 • 189 citations

Activation of Lipoprotein Lipase by Glucose-dependent Insulinotropic Polypeptide in Adipocytes

2007 • 189 citations

Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men

2007 • 188 citations

Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK

1992 • 183 citations

An anterograde tracing study of the vagal innervation of rat liver, portal vein and biliary system

1992 • 181 citations

Gastrointestinal adaptation to diets of differing fat composition in human volunteers.

1991 • 181 citations

Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes

2008 • 180 citations

The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans

2011 • 179 citations

Differential Composition of 5-Hydroxytryptamine₃Receptors Synthesized in the Rat CNS and Peripheral Nervous System

2002 • 177 citations

Secretory granules of endocrine and chief cells of human stomach mucosa contain leptin

2000 • 175 citations

Identification of Neuropeptide W as the Endogenous Ligand for Orphan G-protein-coupled Receptors GPR7 and GPR8

2002 • 175 citations

Serotonin released from intestinal enterochromaffin cells mediates luminal non–cholecystokinin-stimulated pancreatic secretion in rats

2000 • 174 citations

Amino acids stimulate cholecystokinin release through the Ca²⁺-sensing receptor

2010 • 174 citations

Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance

2006 • 174 citations

Role of cholecystokinin in the regulation of gastric emptying and pancreatic enzyme secretion in humans

1991 • 174 citations

Sensory vagal innervation of the rat esophagus and cardia: a light and electron microscopic anterograde tracing study

1987 • 174 citations

An in vitro study of the properties of vagal afferent fibres innervating the ferret oesophagus and stomach

1998 • 172 citations

Preproglucagon neurons project widely to autonomic control areas in the mouse brain

2011 • 171 citations

Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches

1987 • 171 citations

Expression of the calcium-sensing receptor on human antral gastrin cells in culture.

1997 • 170 citations

Orexin-A expression in human peripheral tissues

2003 • 170 citations

Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis

1999 • 169 citations

GPR expression in the rat taste bud relating to fatty acid sensing

2007 • 164 citations

Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse

2011 • 163 citations

Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor

2004 • 162 citations

Rats maintained on high-fat diets exhibit reduced satiety in response to CCK and bombesin

1998 • 160 citations

Role of the glucagon-like-peptide-1 receptor in the control of energy balance

2010 • 159 citations

Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients

1988 • 158 citations

Expression of 5-HT₃ receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying

2003 • 158 citations

Abdominal vagal afferent neurones: an important target for the treatment of gastrointestinal dysfunction

2002 • 155 citations

Expression of 5-HT3 receptors in the rat gastrointestinal tract

2002 • 152 citations

Hypothalamic and vagal neuropeptide circuitries regulating food intake

2001 • 149 citations

Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome

2010 • 149 citations

Ghrelin-induced feeding is dependent on nitric oxide

2003 • 148 citations

Gastric inhibitory polypeptide does not inhibit gastric emptying in humans

2004 • 146 citations

Characterization of brainstem preproglucagon projections to the paraventricular and dorsomedial hypothalamic nuclei

2007 • 145 citations

Combined effects of red pepper and caffeine consumption on 24 h energy balance in subjects given free access to foods

2001 • 143 citations

Differential Gene Expression of CCKA and CCKB Receptors in the Rat Brain

1993 • 143 citations

PYY(3–36) reduces food intake and body weight and improves insulin sensitivity in rodent models of diet-induced obesity

2006 • 141 citations

Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis

2010 • 141 citations

Distribution and regulation of protein expression of the free fatty acid receptor GPR120

2009 • 141 citations

Identification of Farnesyl Pyrophosphate and N-Arachidonylglycine as Endogenous Ligands for GPR92

2008 • 137 citations

Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide

2010 • 134 citations

The physiological role of GLP-1 in human: incretin, ileal brake or more?

2004 • 134 citations

Mucosal receptors in the gastric antrum and small intestine of the rat with afferent fibres in the cervical vagus.

1978 • 134 citations

Immunohistochemical mapping of nitric oxide synthase in the rat hypothalamus and colocalization with neuropeptides

1996 • 134 citations

T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach

2010 • 133 citations

Disturbed release of gastrointestinal peptides in anorexia nervosa and in obesity

2000 • 129 citations

The release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed

2006 • 127 citations

Metabotropic Glutamate Receptor 4 Expression in Colorectal Carcinoma and Its Prognostic Significance

2005 • 123 citations

Expression and regulation of cholecystokinin and cholecystokinin receptors in rat nodose and dorsal root ganglia

2001 • 122 citations

GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells

2007 • 122 citations

Expression of the leptin receptor in rat and human nodose ganglion neurones

2002 • 122 citations

Abdominal vagal mediation of the satiety effects of CCK in rats

2004 • 121 citations

Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat

2009 • 119 citations

Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity

2003 • 117 citations

Expression and regulation of the neuropeptide Y Y2 receptor in sensory and autonomic ganglia

1997 • 117 citations

Diet‐induced adaptation of vagal afferent function

2011 • 116 citations

N-Oleoyldopamine Enhances Glucose Homeostasis through the Activation of GPR119

2009 • 116 citations

Selective effects of vagal deafferentation and celiac–superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients

2003 • 115 citations

mGluR1 in the fundic glands of rat stomach

2007 • 112 citations

Expression of Na⁺/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners

2010 • 110 citations

A Role for Neuropeptide W in the Regulation of Feeding Behavior

2003 • 110 citations

Effect of bran, ispaghula, and inert plastic particles on gastric emptying and small bowel transit in humans: the role of physical factors.

1997 • 109 citations

Ghrelin selectively reduces mechanosensitivity of upper gastrointestinal vagal afferents

2007 • 107 citations

Effect of a low dose of intraduodenal fat on satiety in humans: studies using the type A cholecystokinin receptor antagonist loxiglumide.

1994 • 106 citations

Mechanism of action of the calcium-sensing receptor in human antral gastrin cells

2001 • 106 citations

Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans

2003 • 106 citations

Expression of free fatty acid receptor GPR40 in the central nervous system of adult monkeys

2007 • 105 citations

Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding

1999 • 105 citations

Effects of dietary fat on appetite and energy intake in health and obesity — Oral and gastrointestinal sensory contributions

2011 • 103 citations

Immunoreactive Somatostatin in Rat Hypophyseal Portal Blood: Effects of Anesthetics*

1979 • 103 citations

Luminal <scp>l</scp>-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats

2009 • 101 citations

Expression of metabotropic glutamate receptor group I in rat gustatory papillae

2003 • 101 citations

Expression of Na⁺/glucose co-transporter 1 (SGLT1) in the intestine of piglets weaned to different concentrations of dietary carbohydrate

2010 • 101 citations

Immunohistochemical visualization of a metabotropic glutamate receptor

1993 • 100 citations

Presynaptic Melanocortin-4 Receptors on Vagal Afferent Fibers Modulate the Excitability of Rat Nucleus Tractus Solitarius Neurons

2008 • 99 citations

Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: Predominant localization in pancreatic polypeptide-secreting PP-cells

2006 • 99 citations

RESPONSE OF SINGLE VAGAL AFFERENT FIBRES TO MECHANICAL AND CHEMICAL STIMULATION OF THE GASTRIC AND DUODENAL MUCOSA IN CATS

1972 • 98 citations

Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-A receptors

1999 • 97 citations

Characterization of mechanosensitive splanchnic nerve afferent fibers innervating the rat stomach

2001 • 96 citations

Leptin-induced satiation mediated by abdominal vagal afferents

2004 • 95 citations

The hepatic vagal nerve is receptive to incretin hormone glucagon-like peptide-l, but not to glucose-dependent insulinotropic polypeptide, in the portal vein

1996 • 93 citations

CCK-receptor antagonists attenuate suppression of sham feeding by intestinal nutrients

1992 • 92 citations

Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons

2002 • 91 citations

A Western Diet Increases Serotonin Availability in Rat Small Intestine

2010 • 91 citations

Nutrient sensing in the gut: interactions between chemosensory cells, visceral afferents and the secretion of satiation peptides

2011 • 89 citations

Co-expression patterns of the neuropeptides vasoactive intestinal peptide and cholecystokinin with the transduction molecules α-gustducin and T1R2 in rat taste receptor cells

2004 • 89 citations

Vagal stimulation rapidly increases leptin secretion in human stomach

2002 • 88 citations

Cholecystokinin Regulates Expression of Y2 Receptors in Vagal Afferent Neurons Serving the Stomach

2008 • 86 citations

Suppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation

1995 • 85 citations

K-cells and Glucose-Dependent Insulinotropic Polypeptide in Health and Disease

2010 • 84 citations

The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands

2005 • 83 citations

Agonism with the omega-3 fatty acids α-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor

2010 • 82 citations

Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype

2010 • 82 citations

Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK

1999 • 82 citations

Common Genetic Variations in CCK, Leptin, and Leptin Receptor Genes Are Associated With Specific Human Eating Patterns

2006 • 82 citations

The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1

2011 • 80 citations

A high-fat diet attenuates the central response to within-meal satiation signals and modifies the receptor expression of vagal afferents in mice

2009 • 79 citations

Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones

2005 • 78 citations

Vagally mediated effects of glucagon‐like peptide 1: in vitro and in vivo gastric actions

2009 • 78 citations

Intravenous Peptide YY_3‐36 and Y₂ Receptor Antagonism in the Rat: Effects on Feeding Behaviour

2005 • 78 citations

Osmosensitive vagal receptors in the small intestine of the cat

1986 • 77 citations

Gut Hormones and Energy Balance, The Future for Obesity Therapy?

2009 • 77 citations

Tension receptors with vagal afferent fibres in the proximal duodenum and pyloric sphincter of sheep.

1984 • 76 citations

GPR119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms

2010 • 76 citations

Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats

1996 • 76 citations

Identification of a protein hydrolysate responsive G protein-coupled receptor in enterocytes

2006 • 75 citations

Les aff�rences splanchniques provenant des m�canor�cepteurs gastro-intestinaux et p�riton�aux

1973 • 75 citations

Does Your Gut Taste? Sensory Transduction in the Gastrointestinal Tract

1998 • 74 citations

Protein hydrolysate-induced cholecystokinin secretion from enteroendocrine cells is indirectly mediated by the intestinal oligopeptide transporter PepT1

2011 • 74 citations

GABA_B receptors on vagal afferent pathways: peripheral and central inhibition

2001 • 74 citations

Functional expression of the extracellular-Ca2+-sensing receptor in mouse taste cells

2010 • 73 citations

Gastric branch vagotomy blocks nutrient and cholecystokinin-induced suppression of gastric emptying

1993 • 73 citations

Is There a Role for Gastric Accommodation and Satiety in Asymptomatic Obese People?

2001 • 72 citations

Gastrointestinal transit of pellets in rats: effect of size and density

1999 • 72 citations

Diminished satiation in rats exposed to elevated levels of endogenous or exogenous cholecystokinin

2001 • 72 citations

Duodenal nutrient infusions differentially affect sham feeding and Fos expression in rat brain stem

1998 • 71 citations

Physiological Role of Cholecystokinin B/Gastrin Receptor in Leptin Secretion1

1999 • 70 citations

Cholecystokinin Knockout Mice Are Resistant to High-Fat Diet-Induced Obesity

2010 • 69 citations

Oral, gastric and intestinal influences on human feeding

2001 • 69 citations

Defining the Role of Cholecystokinin in the Lipid-Induced Human Brain Activation Matrix

2010 • 68 citations

Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus

2004 • 67 citations

Walking toward a convergence in aging research

2009 • 67 citations

Load-dependent effects of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men

2007 • 67 citations

Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors

2007 • 67 citations

Activation of Vagal Afferents in the Rat Duodenum by Protein Digests Requires PepT1

2005 • 67 citations

Molecular Cloning and Tissue Expression of a Novel Orphan G Protein-Coupled Receptor from Rat Lung

1997 • 67 citations

Developmental and adult expression of rat calcium‐sensing receptor transcripts in neurons and oligodendrocytes

2000 • 66 citations

Variation of Postprandial PYY&lt;sub&gt;3–36&lt;/sub&gt;Response following Ingestion of Differing Macronutrient Meals in Obese Females

2008 • 66 citations

Vagal intramuscular array afferents form complexes with interstitial cells of Cajal in gastrointestinal smooth muscle: analogues of muscle spindle organs?

2011 • 66 citations

Expression of peptides, nitric oxide synthase and NPY receptor in trigeminal and nodose ganglia after nerve lesions

1996 • 65 citations

Melanocortin‐4 receptor expression in a vago‐vagal circuitry involved in postprandial functions

2009 • 65 citations

Chylomicron components activate duodenal vagal afferents via a cholecystokinin A receptor‐mediated pathway to inhibit gastric motor function in the rat

2003 • 65 citations

Dual capsaicin-sensitive afferent pathways mediate inhibition of gastric emptying in rat induced by intestinal carbohydrate

1992 • 63 citations

Plasticity in vagal afferent neurones during feeding and fasting: mechanisms and significance*

2010 • 62 citations

Sensing Via Intestinal Sweet Taste Pathways

2011 • 62 citations

Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake

2005 • 61 citations

Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4

1995 • 61 citations

Expression of metabotropic glutamate receptors in nodose ganglia and the nucleus of the solitary tract

2001 • 61 citations

Involvement of gastrointestinal mechano- and intestinal chemoreceptors in vagal reflexes: an electrophysiological study

1987 • 61 citations

Molecular mechanisms underlying nutrient detection by incretin-secreting cells

2009 • 61 citations

Peripheral Glucagon-like Peptide-1 (GLP-1) and Satiation

2011 • 61 citations

Targeted disruption of the murine CCK₁ receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function

2006 • 59 citations

Peptide YY: A Potential Therapy for Obesity

2005 • 59 citations

Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptor

1993 • 56 citations

Orexins: A Newly Discovered Family of Hypothalamic Regulators of Food Intake

2009 • 55 citations

Effect of Truncal, Selective and Highly Selective Vagotomy on Gastric Emptying and Intestinal Transit of a Food-Barium Meal in Man

1973 • 55 citations

Cocaine- and Amphetamine-Regulated Transcript Mediates the Actions of Cholecystokinin on Rat Vagal Afferent Neurons

2009 • 54 citations

Antral control of canine gastric emptying of solids

1983 • 53 citations

Sites in the brain at which cholecystokinin octapeptide (CCK-8) acts to suppress feeding in rats: A mapping study

1990 • 53 citations

Possible role of PEPT1 in gastrointestinal hormone secretion

2005 • 53 citations

Effects of vagal neuromodulation and vagotomy on control of food intake and body weight in rats.

2003 • 53 citations

Gastrointestinal hormones, energy balance and bariatric surgery

2011 • 53 citations

Nutrient sensing receptors in gastric endocrine cells

2011 • 52 citations

5-HT system in the gut: roles in the regulation of visceral sensitivity and motor functions.

2008 • 52 citations

Effects of vagal and splanchnic section on food intake, weight, serum leptin and hypothalamic neuropeptide Y in rat

2001 • 52 citations

Measurement of gut hormonal peptides in biopsies from human stomach and proximal small intestine.

1983 • 50 citations

The cornucopia of intestinal chemosensory transduction

2009 • 50 citations

Assessment of true splanchnic glucoreceptors in the jejuno-ileum of the cat

1981 • 50 citations

Endogenous cholecystokinin reduces food intake and increases Fos-like immunoreactivity in the dorsal vagal complex but not in the myenteric plexus by CCK₁ receptor in the adult rat

2006 • 48 citations

Xenin, a Gastrointestinal Peptide, Regulates Feeding Independent of the Melanocortin Signaling Pathway

2008 • 48 citations

Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety

2010 • 48 citations

Cholecystokinin inhibits gastric emptying and contracts the pyloric sphincter in rats by interacting with low affinity CCK receptor sites

1994 • 48 citations

The responses of duodenal tension receptors in sheep to pentagastrin, cholecystokinin and some other drugs.

1984 • 47 citations

Glucagon-like peptide-1(9-36)amide metabolite inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese mice

2010 • 47 citations

Central and peripheral neuroendocrine peptides and signalling in appetite regulation: considerations for obesity pharmacotherapy

2007 • 47 citations

Nitric oxide is a central component in neuropeptide regulation of appetite

2011 • 47 citations

Dose-dependent effects of cholecystokinin-8 on antropyloroduodenal motility, gastrointestinal hormones, appetite, and energy intake in healthy men

2008 • 46 citations

Molecular characterization and localization of human metabotropic glutamate receptor type 4

1996 • 46 citations

Orexin-A-induced feeding is dependent on nitric oxide

2005 • 44 citations

Inhibitory effect of GLP-1 on gastric motility persists after vagal deafferentation in pigs

2006 • 43 citations

Immunocytochemical Detection of Orexin A in Endocrine Cells of the Developing Mouse Gut

2002 • 43 citations

Nitric Oxide as an Endogenous Peripheral Modulator of Visceral Sensory Neuronal Function

2009 • 42 citations

Oral and gastrointestinal sensing of dietary fat and appetite regulation in humans: modification by diet and obesity

2010 • 40 citations

Neuropeptide W is present in antral G cells of rat, mouse, and human stomach

2006 • 39 citations

Inhibition of Gastric Electrical and Mechanical Activity by Intraduodenal Agents in Pigs and the Effects of Vagotomy

1977 • 39 citations

Central glucagon like peptide-1 delays solid gastric emptying via central CRF and peripheral sympathetic pathway in rats

2006 • 37 citations

The extracellular calcium-sensing receptor (CaSR) on human esophagus and evidence of expression of the CaSR on the esophageal epithelial cell line (HET-1A)

2007 • 37 citations

Retracted: Serotonin and cholecystokinin synergistically stimulate rat vagal primary afferent neurones

2004 • 37 citations

Serotonin-type 3 receptors mediate intestinal Polycose- and glucose-induced suppression of intake

2005 • 36 citations

Neurochemical phenotype of vagal afferent neurons activated to express C-FOS in response to luminal stimulation in the rat

2004 • 35 citations

Activation of hindbrain neurons in response to gastrointestinal lipid is attenuated by high fat, high energy diets in mice prone to diet-induced obesity

2008 • 35 citations

Microstructural analysis of the anorectic action of peripherally administered 5-HT

1986 • 35 citations

Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans

2010 • 33 citations

Ondansetron attenuates CCK induced satiety and c-fos labeling in the dorsal medulla

2001 • 33 citations

Capsaicin-sensitive vagal fibres and 5-HT3-, gastrin releasing peptide- and cholecystokinin A-receptors are involved in distension-induced inhibition of gastric emptying in the rat

1999 • 32 citations

Serotonin-type 3 receptors mediate intestinal lipid-induced satiation and Fos-like immunoreactivity in the dorsal hindbrain

2006 • 32 citations

Glucose‐dependent insulinotropic polypeptide: from pathophysiology to therapeutic opportunities in obesity‐associated disorders

2011 • 31 citations

Responses of vagal efferent fibres to stimulation of gastric mechano- and chemoreceptors in the anaesthetized ferret

1989 • 31 citations

Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor.

1993 • 30 citations

Human Metabotropic Glutamate Receptor 1: mRNA Distribution, Chromosome Localization and Functional Expression of Two Splice Variants

1996 • 30 citations

Serotonin type-3 receptors mediate cholecystokinin-induced satiation through gastric distension

2006 • 30 citations

The anorectic action of peripherally administered 5-HT is enhanced by vagotomy

1985 • 30 citations

Tas1R1–Tas1R3 taste receptor variants in human fungiform papillae

2009 • 27 citations

Physiological Role of Cholecystokinin B/Gastrin Receptor in Leptin Secretion

1999 • 27 citations

Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCK1 receptor

2010 • 27 citations

Tension receptors in the oesophagus and stomach of the rat.

1975 • 27 citations

Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption

2006 • 26 citations

Expression of neuropeptide W in rat stomach mucosa: Regulation by nutritional status, glucocorticoids and thyroid hormones

2007 • 26 citations

Possible involvement of nitric oxide in chlordiazepoxide-induced feeding in the mouse

1996 • 25 citations

Effects of gastric filling and vagotomy on ingestion, nipple attachment, and weight gain by suckling rats

1983 • 23 citations

Duodenal osmoconcentration and food intake in pigs after ingestion of hypertonic nutrients

1983 • 23 citations

Reduced vagal sensory innervation of the small intestinal myenteric plexus following capsaicin treatment of adult rats

1997 • 22 citations

A Nitric Oxide Synthase Inhibitor NG-Nitro-?-Arginine, Attenuates Glucoprivic Feeding and Deprivation-Induced Drinking in the Mouse

1998 • 17 citations

Antioxidant protection of Bio-normalizer in cerebral ischaemia-reperfusion injury in the gerbil

1993 • 16 citations

Fatty acid binding receptors in intestinal physiology and pathophysiology

2010 • 15 citations

Genetic variation inGlp1rexpression influences the rate of gastric emptying in mice

2007 • 15 citations

Chemosensitivity of unmyelinated axons in isolated human gastric vagus nerve

2007 • 14 citations

NG-nitro-l-arginine Methyl Ester Reduces Stress-Related Feeding in the Rat Tail-Pinch Model

1998 • 14 citations

Oral Presentations

2010 • 9 citations

Distribution pattern of GPRC6A mRNA in mouse tissue by in situ hybridization.

2010 • 8 citations

Expression of GPR30 and GPR43 in oral tissues: deriving new hypotheses on the role of diet in animal physiology and the development of oral cancers

2010 • 8 citations

Comparison between the properties of the vagal and splanchnic glucoreceptors of the small intestine. Involvement in insulin release

1984 • 5 citations

Modulatory Effect of Npw on Mechanosensitivity of Vagal Afferents in Obesity

2011 • 4 citations

Gastric branch vagotomy blocks nutrient and cholecystokinin-induced suppression of gastric emptying

1993 • 3 citations

Opposite Effects of Nitric Oxide on Peripheral Vagal Afferents in Feeding and Fasting

2011 • 1 citations