Effects of dietary fat on appetite and energy intake in health and obesity — Oral and gastrointestinal sensory contributions

Circulating Ghrelin Levels Are Decreased in Human Obesity

2001 • 1,999 citations

Inhibition of Food Intake in Obese Subjects by Peptide YY_3–36

2003 • 1,549 citations

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

2004 • 1,436 citations

Plasma Ghrelin Levels in Lean and Obese Humans and the Effect of Glucose on Ghrelin Secretion

2002 • 1,246 citations

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α

2003 • 1,007 citations

An anorexic lipid mediator regulated by feeding

2001 • 685 citations

Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents

2006 • 626 citations

CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions

2005 • 620 citations

Glucagon-Like Peptide-1 and Glucose-Dependent Insulin-Releasing Polypeptide Plasma Levels in Response to Nutrients

1995 • 572 citations

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

2008 • 543 citations

Attenuated Peptide YY Release in Obese Subjects Is Associated with Reduced Satiety

2005 • 531 citations

Food Fails to Suppress Ghrelin Levels in Obese Humans

2002 • 517 citations

Dietary fat and the regulation of energy intake in human subjects

1987 • 510 citations

Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men.

1999 • 454 citations

Dietary fat and obesity: evidence from epidemiology.

1995 • 440 citations

The role of postprandial releases of insulin and incretin hormones in meal-induced satiety—effect of obesity and weight reduction

2001 • 421 citations

Taste Preference for Fatty Acids Is Mediated by GPR40 and GPR120

2010 • 397 citations

Attenuated GLP-1 secretion in obesity: cause or consequence?

1996 • 374 citations

The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity

2001 • 371 citations

GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

2009 • 353 citations

The Lipid Messenger OEA Links Dietary Fat Intake to Satiety

2008 • 344 citations

Plasma Ghrelin Levels in Lean and Obese Humans and the Effect of Glucose on Ghrelin Secretion

2002 • 342 citations

Gastrointestinal Satiety Signals

2007 • 323 citations

Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine

2008 • 322 citations

Diet composition, energy intake, and exercise in relation to body fat in men and women

1990 • 316 citations

Oral sensitivity to fatty acids, food consumption and BMI in human subjects

2010 • 311 citations

Gastrointestinal Satiety Signals I. An overview of gastrointestinal signals that influence food intake

2004 • 306 citations

A relation between the chain length of fatty acids and the slowing of gastric emptying

1968 • 301 citations

Satiety after preloads with different amounts of fat and carbohydrate: implications for obesity

1994 • 291 citations

GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans

1999 • 277 citations

Gastric emptying and obesity

1983 • 270 citations

Regulation of gastric emptying in humans by cholecystokinin.

1986 • 269 citations

Free fatty acids induce cholecystokinin secretion through GPR120

2007 • 265 citations

The G-Protein−Coupled Receptor GPR40 Directly Mediates Long-Chain Fatty Acid−Induced Secretion of Cholecystokinin

2010 • 262 citations

Oleoylethanolamide, an endogenous PPAR-α agonist, lowers body weight and hyperlipidemia in obese rats

2005 • 261 citations

Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility

1999 • 260 citations

Sensory preferences for fats: relationships with diet and body composition

1991 • 258 citations

Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility

1999 • 245 citations

Gastric distension and gastric capacity in relation to food intake in humans

1988 • 240 citations

Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-α

2009 • 239 citations

The role of dietary fat in obesity.

1997 • 237 citations

Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length

2004 • 232 citations

Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats

1997 • 230 citations

The gustatory pathway is involved in CD36‐mediated orosensory perception of long‐chain fatty acids in the mouse

2007 • 227 citations

Evidence for Human Orosensory (Taste?) Sensitivity to Free Fatty Acids

2007 • 200 citations

Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans

2003 • 193 citations

The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans

2000 • 190 citations

Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion

1989 • 187 citations

How the Brain Represents the Reward Value of Fat in the Mouth

2009 • 186 citations

Linoleic Acid Induces Calcium Signaling, Src Kinase Phosphorylation, and Neurotransmitter Release in Mouse CD36-positive Gustatory Cells

2008 • 186 citations

Gastrointestinal adaptation to diets of differing fat composition in human volunteers.

1991 • 181 citations

Antropyloroduodenal motor responses to intraduodenal lipid infusion in healthy volunteers

1988 • 177 citations

Intestinal control of gastric tone

1985 • 177 citations

CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice

2007 • 177 citations

Satiety effects of a physiological dose of cholecystokinin in humans.

1995 • 176 citations

Energy intake and appetite are related to antral area in healthy young and older subjects

2004 • 175 citations

Is There a Fatty Acid Taste?

2009 • 170 citations

Effects of Peptide YY and Neuropeptide Y on Gastric Emptying in Man

1984 • 166 citations

Gustatory mechanisms for the detection of fat

1998 • 162 citations

Comparison of the Effects of a High-Fat and High-Carbohydrate Soup Delivered Orally and Intragastrically on Gastric Emptying, Appetite, and Eating Behaviour

1999 • 162 citations

Cholecystokinin-A receptors modulate gastric sensory and motor responses to gastric distension and duodenal lipid

1996 • 161 citations

Fat digestion is required for suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid

2005 • 160 citations

Rats maintained on high-fat diets exhibit reduced satiety in response to CCK and bombesin

1998 • 160 citations

Independent influences of body mass and gastric volumes on satiation in humans

2004 • 156 citations

GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis

2009 • 155 citations

Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men

2011 • 154 citations

Fat taste and lipid metabolism in humans

2005 • 153 citations

Inhibition of gastric emptying by sodium oleate depends on length of intestine exposed to nutrient

1990 • 152 citations

Fat digestion modulates gastrointestinal sensations induced by gastric distention and duodenal lipid in humans

2001 • 151 citations

Peptide YY Is a Regulator of Energy Homeostasis in Obese Children before and after Weight Loss

2005 • 146 citations

Localization of the Lipid Receptors CD36 and CLA-1/SR-BI in the Human Gastrointestinal Tract: Towards the Identification of Receptors Mediating the Intestinal Absorption of Dietary Lipids

2001 • 144 citations

Fat preference and adherence to a reduced-fat diet

1993 • 137 citations

Gut expression and regulation of FAT/CD36: possible role in fatty acid transport in rat enterocytes

2001 • 136 citations

Carbohydrates, fats, and satiety

1995 • 133 citations

Apical CD36 immunolocalization in human and porcine taste buds from circumvallate and foliate papillae

2010 • 133 citations

Disturbed release of gastrointestinal peptides in anorexia nervosa and in obesity

2000 • 129 citations

Vagal stimulation exaggerates the inhibitory ghrelin response to oral fat in humans

2004 • 128 citations

The release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed

2006 • 127 citations

Fatty acid responses in taste cells from obesity-prone and -resistant rats

2005 • 127 citations

Dietary Fat Preferences Are Inversely Correlated with Peripheral Gustatory Fatty Acid Sensitivity^a

1998 • 126 citations

Topography and measurement of pyloric pressure waves and tone in humans

1988 • 124 citations

Food Fails to Suppress Ghrelin Levels in Obese Humans

2002 • 122 citations

Multiple routes of chemosensitivity to free fatty acids in humans

2007 • 121 citations

Adaptation to a High-Fat Diet Leads to Hyperphagia and Diminished Sensitivity to Cholecystokinin in Rats

2005 • 119 citations

Gastrointestinal function in obesity: Motility, secretion, and absorption following a liquid test meal

1992 • 119 citations

Adaptation to high-fat diet reduces inhibition of gastric emptying by CCK and intestinal oleate

2000 • 118 citations

Oral Detection of Short-, Medium-, and Long-Chain Free Fatty Acids in Humans

2008 • 109 citations

Oral fat exposure alters postprandial lipid metabolism in humans

1996 • 108 citations

Adaptation to high-fat diets: effects on eating behaviour and plasma cholecystokinin

1995 • 108 citations

Preliminary studies on the gastrointestinal responses to fatty meals in obese people.

1993 • 107 citations

Effect of a low dose of intraduodenal fat on satiety in humans: studies using the type A cholecystokinin receptor antagonist loxiglumide.

1994 • 106 citations

Free Fatty Acids Have More Potent Effects on Gastric Emptying, Gut Hormones, and Appetite Than Triacylglycerides

2007 • 106 citations

High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men

2003 • 105 citations

Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats

2008 • 104 citations

Colocalization of GPR120 with phospholipase-Cβ2 and α-gustducin in the taste bud cells in mice

2008 • 101 citations

Chemical specificities and intestinal distributions of nutrient-driven satiety

1998 • 97 citations

Dynamics of Fat Absorption and Effect of Sham Feeding on Postprandial Lipema

2010 • 94 citations

Satiety effects of cholecystokinin in humans

1994 • 93 citations

Responses of celiac and cervical vagal afferents to infusions of lipids in the jejunum or ileum of the rat

2000 • 92 citations

Cholecystokinin pathways modulate sensations induced by gastric distension in humans

2004 • 91 citations

Inhibition of gastric emptying in response to intestinal lipid is dependent on chylomicron formation

1998 • 86 citations

Appetite dysfunction in obese males: evidence for role of hyperinsulinaemia in passive overconsumption with a high fat diet

2000 • 84 citations

CD36 may determine our desire for dietary fats

2005 • 83 citations

Plasma glucagon-like peptide-1 (GLP-1) responses to duodenal fat and glucose infusions in lean and obese men

2002 • 81 citations

Tasting fat: Cephalic phase hormonal responses and food intake in restrained and unrestrained eaters

2006 • 77 citations

Decreased expression of CD36 in circumvallate taste buds of high-fat diet induced obese rats

2010 • 77 citations

Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats

1996 • 76 citations

Reduced sensitivity to the satiation effect of intestinal oleate in rats adapted to high-fat diet

1999 • 75 citations

Is There a Role for Gastric Accommodation and Satiety in Asymptomatic Obese People?

2001 • 72 citations

Diminished satiation in rats exposed to elevated levels of endogenous or exogenous cholecystokinin

2001 • 72 citations

Effect of short-term starvation on gastric emptying in humans: relationship to oral glucose tolerance

1995 • 71 citations

Pyloric electrical stimulation reduces food intake by inhibiting gastric motility in dogs

2005 • 71 citations

Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: a study with orlistat, a highly specific lipase inhibitor

2000 • 69 citations

Defining the Role of Cholecystokinin in the Lipid-Induced Human Brain Activation Matrix

2010 • 68 citations

Reduced hindbrain and enteric neuronal response to intestinal oleate in rats maintained on high-fat diet

2000 • 67 citations

New Frontiers in Gut Nutrient Sensor Research: Free Fatty Acid Sensing in the Gastrointestinal Tract

2010 • 66 citations

Effect of increasing the caloric/osmotic content of the liquid component of a mixed solid and liquid meal on gastric emptying in obese subjects.

1986 • 62 citations

Localization of Receptors Inhibiting Gastric Emptying in the Gut

1977 • 61 citations

Adaptation to high-fat diet accelerates emptying of fat but not carbohydrate test meals in humans

2002 • 61 citations

Deficits in gastrointestinal responses controlling food intake and body weight

2010 • 58 citations

Gastric emptying in obesity.

1986 • 56 citations

Apolipoprotein A-IV stimulates duodenal vagal afferent activity to inhibit gastric motility via a CCK₁ pathway

2004 • 54 citations

Pooled-data analysis identifies pyloric pressures and plasma cholecystokinin concentrations as major determinants of acute energy intake in healthy, lean men

2010 • 53 citations

Lipase inhibition attenuates the acute inhibitory effects of oral fat on food intake in healthy subjects

2003 • 48 citations

Brief oral stimulation, but especially oral fat exposure, elevates serum triglycerides in humans

2008 • 47 citations

Chylomicron components mediate intestinal lipid-induced inhibition of gastric motor function

2002 • 47 citations

Gastric emptying in normal weight and obese children—an ultrasound study

1999 • 47 citations

Satiety and substrate mobilization after oral fat stimulation

2006 • 45 citations

Role of small intestine in caloric compensations to oil premeals in rats

1998 • 44 citations

A high-fat diet raises fasting plasma CCK but does not affect upper gut motility, PYY, and ghrelin, or energy intake during CCK-8 infusion in lean men

2007 • 36 citations

Activation of hindbrain neurons in response to gastrointestinal lipid is attenuated by high fat, high energy diets in mice prone to diet-induced obesity

2008 • 35 citations

Effects of acute dietary restriction on gut motor, hormone and energy intake responses to duodenal fat in obese men

2010 • 32 citations

Effects of oral fat perception by modified sham feeding on energy expenditure, hormones and appetite profile in the postprandial state

2008 • 32 citations

Gastric lipase secretion after sham feeding and cholinergic blockade.

1997 • 32 citations

Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption

2006 • 26 citations

CD36 (OKM5) Antigen Expression on Human Mucosal Epithelia Is Associated with Keratinization Type

1997 • 4 citations