CD8+ Cells in Human Immunodeficiency Virus Type I Pathogenesis: Cytolytic and Noncytolytic Inhibition of Viral Replication

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time

1996 • 3,496 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

1996 • 3,106 citations

Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 ⁺ T Cells

1995 • 2,890 citations

CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

1996 • 2,735 citations

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1994 • 2,529 citations

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

1996 • 2,326 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy

1995 • 1,997 citations

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1996 • 1,973 citations

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

1994 • 1,899 citations

A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors

1996 • 1,868 citations

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

1996 • 1,678 citations

Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains.

1994 • 1,400 citations

The role of a mutant CCR5 allele in HIV–1 transmission and disease progression

1996 • 1,364 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Genotypic and Phenotypic Characterization of HIV-1 Patients with Primary Infection

1993 • 1,258 citations

Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones

1992 • 1,227 citations

Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS)

1983 • 1,222 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1997 • 1,206 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5

1996 • 1,181 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1997 • 1,135 citations

Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes

1996 • 1,085 citations

CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5

1996 • 1,058 citations

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1996 • 1,041 citations

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

1991 • 1,025 citations

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

Transient High Levels of Viremia in Patients with Primary Human Immunodeficiency Virus Type 1 Infection

1991 • 851 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

1990 • 775 citations

HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women

1995 • 750 citations

The Th1–Th2 hypothesis of HIV infection: new insights

1994 • 708 citations

High Titers of Cytopathic Virus in Plasma of Patients with Symptomatic Primary HIV-1 Infection

1991 • 697 citations

Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease

1991 • 686 citations

Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

1989 • 662 citations

Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.

1995 • 650 citations

Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV

1994 • 611 citations

ASSOCIATION BETWEEN BIOLOGICAL PROPERTIES OF HUMAN IMMUNODEFICIENCY VIRUS VARIANTS AND RISK FOR AIDS AND AIDS MORTALITY

1989 • 581 citations

AIDS virus-specific cytotoxic T lymphocytes in lung disorders

1987 • 539 citations

Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus

1978 • 528 citations

High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors

1995 • 519 citations

Immunopathogenic Mechanisms of HIV Infection

1996 • 514 citations

Chemokines: leucocyte recruitment and activation cytokines

1997 • 480 citations

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

1996 • 452 citations

HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

1988 • 447 citations

Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells

1996 • 434 citations

Increases in CD4 T Lymphocytes with Intermittent Courses of Interleukin-2 in Patients with Human Immunodeficiency Virus Infection — A Preliminary Study

1995 • 430 citations

Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease.

1993 • 427 citations

Toward an Understanding of the Correlates of Protective Immunity to HIV Infection

1996 • 421 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

1995 • 383 citations

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms

1997 • 345 citations

Reduction of HIV Concentration During Acute Infection: Independence from a Specific Immune Response

1996 • 335 citations

Strong Cytotoxic T Cell and Weak Neutralizing Antibody Responses in a Subset of Persons with Stable Nonprogressing HIV Type 1 Infection

1996 • 331 citations

Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load.

1996 • 330 citations

Kaposiʼs sarcoma-associated herpesvirus infection prior to onset of Kaposiʼs sarcoma

1996 • 330 citations

Antigenic oscillations and shifting immunodominance in HIV-1 infections

1995 • 325 citations

Follicular dendritic cells and human immunodeficiency virus infectivity

1995 • 313 citations

Chemokines and HIV–1 second receptors

1996 • 304 citations

T-cell subset alterations in HIV-infected homosexual men: NIAID multicenter AIDS cohort study

1989 • 297 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo

1984 • 296 citations

The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia

1997 • 282 citations

CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual.

1991 • 279 citations

Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.

1994 • 274 citations

HIV-1 Reverse Transcriptase Is a Target for Cytotoxic T Lymphocytes in Infected Individuals

1988 • 270 citations

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.

1991 • 266 citations

Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1

1995 • 263 citations

A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes.

1989 • 258 citations

ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids.

1995 • 253 citations

Anergy and apoptosis in CD8+ T cells from HIV-infected persons.

1994 • 252 citations

Cytoimitiunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system

1986 • 250 citations

CD8+ T cells suppress human immunodeficiency virus replication by inhibiting viral transcription.

1995 • 247 citations

Sequence motifs important for peptide binding to the human MHC class I molecule, HLA-A2.

1992 • 246 citations

Novel, Cross-Restricted, Conserved, and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow Progressors in HIV Type 1 Infection

1996 • 241 citations

Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1.

1989 • 241 citations

Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients.

1994 • 238 citations

Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteers

1997 • 234 citations

Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.

1994 • 232 citations

Repression of MHC Class I Gene Promoter Activity by Two-Exon Tat of HIV

1993 • 223 citations

Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes

1996 • 222 citations

Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.

1994 • 221 citations

A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication.

1989 • 221 citations

Antiviral Effect and Ex Vivo CD4 ⁺ T Cell Proliferation in HIV-Positive Patients as a Result of CD28 Costimulation

1996 • 219 citations

Differential Regulation of HIV-1 Fusion Cofactor Expression by CD28 Costimulation of CD4⁺T Cells

1997 • 206 citations

Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors

1994 • 204 citations

CD8+ T cells inhibit HIV replication in naturally infected CD4+ T cells. Evidence for a soluble inhibitor.

1990 • 196 citations

CD8⁺Cell Anti-HIV Activity: Nonlytic Suppression of Virus Replication

1992 • 194 citations

HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells.

1991 • 191 citations

An Activated CD8+ T Cell Phenotype Correlates with Anti-HIV Activity and Asymptomatic Clinical Status

1993 • 189 citations

A Single Residue Exchange Within a Viral CTL Epitope Alters Proteasome-Mediated Degradation Resulting in Lack of Antigen Presentation

1996 • 181 citations

A Single Amino Acid Interchange Yields Reciprocal CTL Specificities for HIV-1 gp160

1989 • 181 citations

Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope.

1994 • 179 citations

Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein.

1994 • 175 citations

Inhibition of human immunodeficiency virus replication in acutely infected CD4+ cells by CD8+ cells involves a noncytotoxic mechanism

1991 • 173 citations

An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.

1991 • 172 citations

MHC molecules as peptide receptors

1993 • 169 citations

Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors.

1995 • 163 citations

Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled.

1977 • 161 citations

Changing Virus‐Host Interactions in the Course of HIV‐1 Infection

1994 • 157 citations

Virus Burden in Long-Term Survivors of Human Immunodeficiency Virus (HIV) Infection Is a Determinant of Anti-HIV CD8+ Lymphocyte Activity

1995 • 157 citations

Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes.

1988 • 157 citations

Protection of Mice from Fatal Herpes Simplex Virus Type 1 Infection by Adoptive Transfer of Cloned Virus-specific and H-2-restricted Cytotoxic T Lymphocytes

1983 • 149 citations

Effect of Cytokines on HIV Replication in CD4+ Lymphocytes: Lack of Identity with the CD8+ Cell Antiviral Factor

1994 • 143 citations

Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells

1997 • 142 citations

Identification of overlapping HLA class I-restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation.

1992 • 139 citations

Cooperation between cytotoxic and helper T lymphocytes in protection against lethal Sendai virus infection. Protection by T cells is MHC-restricted and MHC-regulated; a model for MHC-disease associations.

1986 • 139 citations

Effects of TH1 and TH2 cytokines on CD8+ cell response against human immunodeficiency virus: implications for long-term survival.

1995 • 139 citations

Six epitopes reacting with human cytotoxic CD8+ T cells in the central region of the HIV-1 NEF protein.

1991 • 138 citations

Mapping the fine specificity of a cytolytic T cell response to HIV-1 nef protein.

1990 • 133 citations

Non-cytolytic CD8 T-cell anti-HIV responses in primary HIV-1 infection

1994 • 130 citations

Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens

1993 • 127 citations

Antigen detection in primary HIV infection

1988 • 125 citations

Mechanism of recovery from acute virus infection. I. Role of T lymphocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice.

1985 • 117 citations

Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis

1995 • 115 citations

Dynamics of viral variants in HIV-1 Nef and specific cytotoxic T lymphocytes in vivo.

1996 • 114 citations

Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone

1993 • 112 citations

Limiting dilution analysis of cytotoxic T lymphocytes to human immunodeficiency virus gag antigens in infected persons: in vitro quantitation of effector cell populations with p17 and p24 specificities.

1991 • 111 citations

High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals

1990 • 110 citations

Flow cytometric analysis of lymphocyte phenotypes in AIDS using monoclonal antibodies and simultaneous dual immunofluorescence

1986 • 109 citations

Cytotoxic T Lymphocyte Lysis Inhibited by Viable HIV Mutants

1995 • 107 citations

Flanking residues alter antigenicity and immunogenicity of multi-unit CTL epitopes.

1996 • 102 citations

CD8⁺T Lymphocyte-Mediated Inhibition of HIV-1 Long Terminal Repeat Transcription: A Novel Antiviral Mechanism

1993 • 99 citations

An HLA-A11-specific motif in nonamer peptides derived from viral and cellular proteins.

1993 • 96 citations

Down-modulation of MHC-I in a CD4+ T cell line, CEM-E5, after HIV-1 infection.

1989 • 93 citations

Suppression of human immunodeficiency virus replication by CD8+ cells from infected and uninfected chimpanzees

1991 • 89 citations

Recognition of the Highly Conserved YMDD Region in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by HLA-A2-Restricted Cytotoxic T Lymphocytes from an Asymptomatic Long-Term Nonprogressor

1996 • 87 citations

Gag-specific cytotoxic T lymphocytes from human immunodeficiency virus type 1-infected individuals: Gag epitopes are clustered in three regions of the p24gag protein

1993 • 86 citations

Predominant involvement of CD8+CD28- lymphocytes in human immunodeficiency virus-specific cytotoxic activity

1996 • 83 citations

Theoretical biology and biophysics

1971 • 82 citations

Cytotoxic T lymphocytes from HIV-1 seropositive individuals recognize immunodominant epitopes in Gp160 and reverse transcriptase.

1992 • 81 citations

CD8+ T cells from HIV-1-infected individuals inhibit acute infection by human and primate immunodeficiency viruses

1991 • 80 citations

In vivo persistence of a HIV‐1‐encoded HLA‐B27‐restricted cytotoxic T lymphocyte epitope despite specific in vitro reactivity

1991 • 78 citations

Identification of type-specific cytotoxic T lymphocyte responses to homologous viral proteins in laboratory workers accidentally infected with HIV-1.

1997 • 76 citations

CD8+ T lymphocytes of African green monkeys secrete an immunodeficiency virus-suppressing lymphokine.

1994 • 76 citations

Interference with human immunodeficiency virus (HIV) replication by CD8+ T cells in peripheral blood leukocytes of asymptomatic HIV carriers in vitro

1990 • 76 citations

Antigen-Specific T-Cell Receptors and Their Reactions with Complexes Formed by Peptides with Major Histocompatibility Complex Proteins

1996 • 75 citations

Suppression of Activation of the Human Immunodeficiency Virus Long Terminal Repeat by CD8⁺T Cells Is Not Lentivirus Specific

1995 • 74 citations

Mutation of human immunodeficiency virus type 1 at amino acid 585 on gp41 results in loss of killing by CD8+ A24-restricted cytotoxic T lymphocytes

1992 • 73 citations

Recovery from Acute Virus Infection

1988 • 70 citations

Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine

1994 • 66 citations

Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognition

1997 • 66 citations

Cytotoxic T cells in HIV2 seropositive Gambians. Identification of a virus-specific MHC-restricted peptide epitope.

1993 • 65 citations

Downregulation of HLA Class I Antigens in HIV-1-Infected Cells

1989 • 64 citations

Identification of multiple HIV-1 cytotoxic T-cell epitopes presented by human leukocyte antigen B35 molecules.

1996 • 64 citations

T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant.

1996 • 60 citations

Multifactorial Nature of Noncytolytic CD8⁺T Cell-Mediated Suppression of HIV Replication: β-Chemokine-Dependent and -Independent Effects

1997 • 56 citations

Specific lysis of human immunodeficiency virus type 1-infected cells by a HLA-A3.1-restricted CD8+ cytotoxic T-lymphocyte clone that recognizes a conserved peptide sequence within the gp41 subunit of the envelope protein.

1991 • 55 citations

Dual Function of a Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Clone: Inhibition of HIV Replication by Noncytolytic Mechanisms and Lysis of HIV-Infected CD4+ Cells

1996 • 53 citations

A region of the third variable loop of HIV-1 gp120 is recognized by HLA-B7-restricted CTLs from two acute seroconversion patients.

1994 • 51 citations

Inhibition of cellular activation of retroviral replication by CD8+ T cells derived from non-human primates

1993 • 51 citations

Identification of multiple and distinct CD8+ T cell suppressor activities: dichotomy between infected and uninfected individuals, evolution with progression of disease, and sensitivity to gamma irradiation.

1996 • 50 citations

Oligoclonal CD8 Lymphocytes from Persons with Asymptomatic Human Immunodeficiency Virus (HIV) Type 1 Infection Inhibit DIV-1 Replication

1995 • 48 citations

Regulation of class I-restricted epitope processing by local or distal flanking sequence.

1997 • 47 citations

HIV-1-specific cytotoxic T lymphocyte response in healthy, long-term nonprogressing seropositive persons.

1994 • 46 citations

Characterization of HLA-A 0201-restricted cytotoxic T cell epitopes in conserved regions of the HIV type 1 gp160 protein.

1995 • 45 citations

Suppression of HIV Replication by CD8+ Cell Clones Derived from HIV-Infected and Uninfected Individuals

1994 • 45 citations

Genetic Variation in Retroviruses

1990 • 44 citations

Are HIV-specific CTL responses salutary or pathogenic?

1995 • 44 citations

Ex Vivo Expansion of CD4 Lymphocytes from Human Immunodeficiency Virus Type 1-Infected Persons in the Presence of Combination Antiretroviral Agents

1995 • 41 citations

Class II (DR) antigen expression on CD8+ lymphocyte subsets in acquired immune deficiency syndrome (AIDS)

1988 • 37 citations

Cytotoxic T Lymphocytes in Human Immunodeficiency Virus Infection: Responses to Structural Proteins

1994 • 37 citations

Cloned human CD8+ cytotoxic T lymphocytes protect human peripheral blood leukocyte-severe combined immunodeficient mice from HIV-1 infection by an HLA-unrestricted mechanism.

1994 • 37 citations

CTLs from lymphoid organs recognize an optimal HLA-A2-restricted and HLA-B52-restricted nonapeptide and several epitopes in the C-terminal region of HIV-1 Nef.

1995 • 35 citations

CD8⁺T Cells from HIV Type 1-Seronegative Individuals Suppress Virus Replication in Acutely Infected Cells

1997 • 34 citations

An antigen processing polymorphism revealed by HLA‐B8‐restricted cytotoxic T lymphocytes which does not correlate with TAP gene polymorphism

1993 • 33 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus and in vitro properties

1985 • 29 citations

Cytotoxic T lymphocytes in HIV-induced disease: implications for therapy and vaccination.

1989 • 29 citations

Fine-specificity of cytotoxic T lymphocytes which recognize conserved epitopes of the Gag protein of human immunodeficiency virus type 1

1996 • 26 citations

Cytotoxic T-lymphocyte induction in asymptomatic HIV-1-infected patients immunized with Retrovector®-transduced autologous fibroblasts expressing HIV-1IIIB Env/Rev proteins

1995 • 25 citations

Virus Variability, Epidemiology and Control

1990 • 23 citations

Effect of Zidovudine Therapy on CD8+ T Cell Anti-HIV Activity

1994 • 19 citations

CD3, CD8 Double-Positive Cells from HIV-1-Infected Chimpanzees Show Group-Specific Inhibition of HIV-1 Replication

1993 • 18 citations

The Cytotoxic T-Lymphocyte Response in HIV-1 Infection

1994 • 16 citations

Cytotoxic CD8+ T Lymphocytes Reactive with Human Immunodeficiency Virus-1 Produce Granulocyte/Macrophage Colony-Stimulating Factor and Variable Amounts of Interleukins 2, 3, and 4 Following Stimulation with the Cognate Epitope

1995 • 15 citations

Non-cytolytic control of HIV replication by CD8+ T cells

1993 • 12 citations

Tenth international conference on AIDS

1994 • 10 citations

Epitope specificity of MHC restricted cytotoxic T lymphocytes induced by candidate HIV-1 vaccine.

1994 • 7 citations

The cellular immune response to the human immunodeficiency virus

1990 • 6 citations

Identification of HIV-1 cytotoxic T-lymphocyte epitopes and implications for vaccine development.

1991 • 6 citations

Immunosuppression by a Noncytolytic Virus Via T Cell Mediated Immunopathology

1995 • 6 citations

Identification of HIV-1 cytotoxic T-lymphocyte epitopes and implications for vaccine development.

1991 • 5 citations

Identification of multirestricted immunodominant regions recognized by cytolytic T lymphocytes in the human immunodeficiency virus type 1 Nef protein

1995 • 4 citations

Introduction

1995 • 3 citations

Deleted Work

1955 • 0 citations