Cytotoxic T Lymphocytes in Human Immunodeficiency Virus Infection: Responses to Structural Proteins

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS

1984 • 3,647 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene

1992 • 1,025 citations

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

1991 • 1,025 citations

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

1990 • 775 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

1991 • 563 citations

Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor.

1990 • 548 citations

AIDS virus-specific cytotoxic T lymphocytes in lung disorders

1987 • 539 citations

Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.

1985 • 526 citations

HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

1988 • 447 citations

An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes.

1988 • 417 citations

Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera

1990 • 416 citations

Cell Biology of Antigen Processing and Presentation to Major Histocompatibility Complex Class I Molecule-Restricted T Lymphocytes

1992 • 373 citations

Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletion

1988 • 372 citations

Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells

1984 • 318 citations

Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans.

1989 • 318 citations

Viral Persistence in Neurons Explained by Lack of Major Histocompatibility Class I Expression

1991 • 308 citations

HIV-1 Reverse Transcriptase Is a Target for Cytotoxic T Lymphocytes in Infected Individuals

1988 • 270 citations

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.

1991 • 266 citations

A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes.

1989 • 258 citations

Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence

1986 • 242 citations

Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1.

1989 • 241 citations

Emergence of viruses resistant to neutralization by V3-specific antibodies in experimental human immunodeficiency virus type 1 IIIB infection of chimpanzees

1990 • 230 citations

A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication.

1989 • 221 citations

Enhanced immunity to human immunodeficiency virus (HIV) envelope elicited by a combined vaccine regimen consisting of priming with a vaccinia recombinant expressing HIV envelope and boosting with gp160 protein.

1993 • 196 citations

HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells.

1991 • 191 citations

Generation of a neutralization-resistant variant of HIV-1 is due to selection for a point mutation in the envelope gene

1988 • 186 citations

Human macrophages degrade tryptophan upon induction by interferon-gamma

1987 • 182 citations

An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.

1991 • 172 citations

Definition of an epitope and MHC class I molecule recognized by gag-specific cytotoxic T lymphocytes in SIVmac-infected rhesus monkeys.

1991 • 171 citations

Human immunodeficiency virus-specific cytotoxic responses of seropositive individuals: distinct types of effector cells mediate killing of targets expressing gag and env proteins

1989 • 152 citations

Detection of cytotoxic T lymphocytes specific for synthetic peptides of gp160 in HIV-seropositive individuals.

1991 • 150 citations

Induction of CD4⁺Human Cytolytic T Cells Specific for HIV-Infected Cells by a Gp160 Subunit Vaccine

1990 • 148 citations

Interferon gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells.

1992 • 148 citations

Identification of overlapping HLA class I-restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation.

1992 • 139 citations

Six epitopes reacting with human cytotoxic CD8+ T cells in the central region of the HIV-1 NEF protein.

1991 • 138 citations

Immune modulation within the brain: recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-γ

1991 • 136 citations

Mapping the fine specificity of a cytolytic T cell response to HIV-1 nef protein.

1990 • 133 citations

Phenotypic heterogeneity of cerebrospinal fluid-derived HIV-specific and HLA-restricted cytotoxic T-cell clones

1988 • 129 citations

Group-specific, major histocompatibility complex class I-restricted cytotoxic responses to human immunodeficiency virus 1 (HIV-1) envelope proteins by cloned peripheral blood T cells from an HIV-1-infected individual.

1988 • 129 citations

Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens

1993 • 127 citations

Activity of Interferons Alpha, Beta, and Gamma Against Human Immunodeficiency Virus Replication In Vitro

1987 • 125 citations

CELLULAR ANTI-GP120 CYTOLYTIC REACTIVITIES IN HIV-1 SEROPOSITIVE INDIVIDUALS

1988 • 119 citations

Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase

1989 • 115 citations

A viral polymerase involved in recognition of influenza virus-infected cells by a cytotoxic T-cell clone

1982 • 113 citations

Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone

1993 • 112 citations

Limiting dilution analysis of cytotoxic T lymphocytes to human immunodeficiency virus gag antigens in infected persons: in vitro quantitation of effector cell populations with p17 and p24 specificities.

1991 • 111 citations

High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals

1990 • 110 citations

Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex.

1992 • 107 citations

Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children

1991 • 107 citations

An HLA-C-restricted CD8+ cytotoxic T-lymphocyte clone recognizes a highly conserved epitope on human immunodeficiency virus type 1 gag

1991 • 100 citations

Recombinant Virus Vaccine-Induced SIV-specific CD8 ⁺ Cytotoxic T Lymphocytes

1991 • 99 citations

Evidence for a cytotoxic T-lymphocyte alveolitis in human immunodeficiency virus-infected patients.

1988 • 96 citations

Comparative clonal analysis of human immunodeficiency virus type 1 (HIV-1)-specific CD4+ and CD8+ cytolytic T lymphocytes isolated from seronegative humans immunized with candidate HIV-1 vaccines.

1992 • 94 citations

Down-modulation of MHC-I in a CD4+ T cell line, CEM-E5, after HIV-1 infection.

1989 • 93 citations

An antigenic peptide of the HIV‐1 NEF protein recognized by cytotoxic T lymphocytes of seropositive individuals in association with different HLA‐B

1989 • 91 citations

Carboxyl-terminal and central regions of human immunodeficiency virus-1 NEF recognized by cytotoxic T lymphocytes from lymphoid organs. An in vitro limiting dilution analysis.

1992 • 91 citations

Induction and regulation of class II major histocompatibility complex mRNA expression in astrocytes by interferon-γ and tumor necrosis factor-α

1990 • 91 citations

The gag-specific cytotoxic T lymphocytes in rhesus monkeys infected with the simian immunodeficiency virus of macaques.

1990 • 87 citations

Gag-specific cytotoxic T lymphocytes from human immunodeficiency virus type 1-infected individuals: Gag epitopes are clustered in three regions of the p24gag protein

1993 • 86 citations

GP120 specific cellular cytotoxicity in HIV-1 seropositive individuals. Evidence for circulating CD16+ effector cells armed in vivo with cytophilic antibody.

1989 • 85 citations

Detection of major histocompatibility complex class I-restricted, HIV- specific cytotoxic T lymphocytes in the blood of infected hemophiliacs

1989 • 82 citations

Cytotoxic T lymphocytes from HIV-1 seropositive individuals recognize immunodominant epitopes in Gp160 and reverse transcriptase.

1992 • 81 citations

Murine cytotoxic T lymphocyte recognition of individual influenza virus proteins. High frequency of nonresponder MHC class I alleles.

1988 • 79 citations

An epitope in human immunodeficiency virus 1 reverse transcriptase recognized by both mouse and human cytotoxic T lymphocytes.

1990 • 79 citations

In vivo persistence of a HIV‐1‐encoded HLA‐B27‐restricted cytotoxic T lymphocyte epitope despite specific in vitro reactivity

1991 • 78 citations

Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag.

1992 • 76 citations

Detection of HIV-specific cell-mediated cytotoxicity in the peripheral blood from infected children.

1993 • 73 citations

Mutation of human immunodeficiency virus type 1 at amino acid 585 on gp41 results in loss of killing by CD8+ A24-restricted cytotoxic T lymphocytes

1992 • 73 citations

T‐immunogenic peptides are constituted of rare sequence patterns. Use in the identification of T epitopes in the human immunodeficiency virus gag protein

1988 • 73 citations

Cytotoxic T lymphocyte response against multiple simian immunodeficiency virusA (SIV) proteins in SIV-infected macaques.

1992 • 70 citations

A phase 1 study of adoptive transfer of autologous CD8+ T lymphocytes in patients with acquired immunodeficiency syndrome (AIDS)-related complex or AIDS

1993 • 68 citations

Downregulation of HLA Class I Antigens in HIV-1-Infected Cells

1989 • 64 citations

Class I major histocompatibility complex-restricted cytolytic T lymphocytes recognize a limited number of sites on the influenza hemagglutinin.

1989 • 64 citations

HGP-30, a synthetic analogue of human immunodeficiency virus (HIV) p17, is a target for cytotoxic lymphocytes in HIV-infected individuals.

1990 • 57 citations

Characterization of a conserved T cell epitope in HIV-1 gp41 recognized by vaccine-induced human cytolytic T cells.

1991 • 56 citations

Specific lysis of human immunodeficiency virus type 1-infected cells by a HLA-A3.1-restricted CD8+ cytotoxic T-lymphocyte clone that recognizes a conserved peptide sequence within the gp41 subunit of the envelope protein.

1991 • 55 citations

Evidence of widespread binding of HLA class I molecules to peptides.

1990 • 55 citations

Enhancement of human immunodeficiency virus (HIV)-specific CD4+ and CD8+ cytotoxic T-lymphocyte activities in HIV-infected asymptomatic patients given recombinant gp160 vaccine.

1992 • 54 citations

Studies of cloned simian immunodeficiency virus-specific T lymphocytes. gag-specific cytotoxic T lymphocytes exhibit a restricted epitope specificity.

1990 • 53 citations

Analysis of physical interactions between peptides and HLA molecules and application to the detection of human immunodeficiency virus 1 antigenic peptides.

1990 • 53 citations

A CD4+ cytotoxic T-lymphocyte clone to a conserved epitope on human immunodeficiency virus type 1 p24: cytotoxic activity and secretion of interleukin-2 and interleukin-6

1992 • 51 citations

Detection of primary cytotoxic T lymphocytes specific for the envelope glycoprotein of HIV‐1 by deletion of the env amino‐terminal signal sequence

1990 • 49 citations

Induction of HIV-Specific CTL and Antibody Responses in Mice Using Retroviral Vector-Transduced Cells

1991 • 45 citations

An HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope

1990 • 38 citations

Equivalent recognition of HIV proteins, Env, Gag and Pol, by CD4 + and CD8 + cytotoxic T-Iymphocytes

1992 • 35 citations

Two distinct lymphocyte populations mediate simian immunodeficiency virus envelope-specific target cell lysis.

1990 • 35 citations

An activated CD8+ lymphocyte appears in lymph nodes of rhesus monkeys early after infection with simian immunodeficiency virus.

1991 • 33 citations

CD4⁺Human Immunodeficiency Virus Type 1 (HIV-1) Envelope-Specific Cytotoxic T Lymphocytes Derived from the Peripheral Blood Cells of an HIV-1-Infected Individual

1993 • 32 citations

Genetic variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor.

1990 • 30 citations

Simian immunodeficiency virus-specific cytotoxic T lymphocytes are present in the AIDS-associated skin rash in rhesus monkeys.

1992 • 28 citations

Cytotoxic T-cell epitopes in HIV/SIV infection

1993 • 26 citations

Recognition of HIV glycoprotein gp120 by T cells. Role of monocyte CD4 in the presentation of gp120.

1989 • 24 citations

Three epitopic peptides of the simian immunodeficiency virus Nef protein recognized by macaque cytolytic T lymphocytes

1992 • 24 citations

Carboxyl-terminal and Central Regions of Human Immunodeficiency Virus-1 NEF Recognized by Cytotoxic T Lymphocytes from Lymphoid Organs

1992 • 22 citations

HIV-specific cytotoxic T lymphocytes against alveolar macrophages: specificities and downregulation

1991 • 21 citations

Induction of HIV-1 replication in a chronically infected T-cell line by cytotoxic T lymphocytes.

1993 • 20 citations

HIV-specific cytotoxic T lymphocytes directed against alveolar macrophages in HIV-infected patients

1990 • 20 citations

Characterization of simian immunodeficiency virus-specific T-cell-mediated cytotoxic response of infected rhesus macaques

1989 • 19 citations

HLA-binding regions of HIV-1 proteins. II. A systematic study of viral proteins.

1991 • 16 citations

HLA-binding regions of HIV-1 proteins. I. Detection of seven HLA binding regions in the HIV-1 Nef protein.

1991 • 13 citations

LFA1 expression in HIV infection.

1988 • 11 citations

Clonal Analysis of T-Cell Responses to the HIV-1 Envelope Proteins in AIDS Vaccine Recipients

1992 • 10 citations

Multiple cytotoxic effector cells are induced by infection with the human immunodeficiecy virus

1989 • 9 citations