Fully mobilizing host defense: Building better vaccines

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response

1997 • 1,536 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

New use of BCG for recombinant vaccines

1991 • 1,463 citations

Origin, maturation and antigen presenting function of dendritic cells

1997 • 1,375 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

DNA VACCINES

1997 • 977 citations

Cytotoxic T-Cell Immunity to Influenza

1983 • 932 citations

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

1996 • 922 citations

A Phagosome-to-Cytosol Pathway for Exogenous Antigens Presented on MHC Class I Molecules

1995 • 882 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES

1997 • 779 citations

The mannose receptor is a pattern recognition receptor involved in host defense

1998 • 640 citations

In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine

1989 • 632 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.

1993 • 592 citations

A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer

1996 • 538 citations

Generation of Human Cytotoxic T Cells Specific for Human Carcinoembryonic Antigen Epitopes From Patients Immunized With Recombinant Vaccinia-CEA Vaccine

1995 • 506 citations

Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs

1990 • 479 citations

Biologic Therapy of Cancer

1992 • 476 citations

Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice.

1997 • 455 citations

Co-stimulation in T cell responses

1997 • 430 citations

A new foreign policy: MHC class I molecules monitor the outside world

1996 • 422 citations

Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages

1995 • 416 citations

Cytokine regulation of T-cell function: potential for therapeutic intervention

1993 • 412 citations

Vaccinia Virus: A Tool for Research and Vaccine Development

1991 • 410 citations

Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer

1997 • 383 citations

Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules.

1994 • 383 citations

Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation?

1995 • 347 citations

Presentation of Exogenous Antigen with Class I Major Histocompatibility Complex Molecules

1990 • 338 citations

Chimeric papillomavirus virus-like particles elicit antitumor immunity against the E7 oncoprotein in an HPV16 tumor model

1998 • 326 citations

Protection against gram-negative bacteremia and endotoxemia with human monoclonal IgM antibodies.

1985 • 316 citations

Humoral and cell-mediated immune responses to live recombinant BCG–HIV vaccines

1991 • 315 citations

The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice.

1991 • 306 citations

Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis.

1995 • 300 citations

Cancer Tumor antigens

1997 • 289 citations

Characterization of a messenger RNA polynucleotide vaccine vector.

1995 • 286 citations

Monophosphoryl lipid A as an adjuvant. Past experiences and new directions.

1995 • 283 citations

Protection Against Vaginal SIV Transmission with Microencapsulated Vaccine

1993 • 265 citations

MHC Class I–Restricted CTL Responses to Exogenous Antigens

1996 • 265 citations

Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway

1997 • 253 citations

Oral Salmonella typhimurium Vaccine Expressing Circumsporozoite Protein Protects Against Malaria

1988 • 250 citations

Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome

1995 • 249 citations

Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine.

1992 • 240 citations

Saponin adjuvant induction of ovalbumin-specific CD8+ cytotoxic T lymphocyte responses.

1992 • 224 citations

Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules.

1993 • 206 citations

Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro.

1992 • 185 citations

Drug carriers in biology and medicine

1979 • 184 citations

Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory.

1995 • 180 citations

Immunity to Oncogenic Proteins

1995 • 180 citations

HER-2/neu Protein: A Target for Antigen-Specific Immunotherapy of Human Cancer

1997 • 173 citations

Recombinant parvovirus-like particles as an antigen carrier: A novel nonreplicative exogenous antigen to elicit protective antiviral cytotoxic T cells

1997 • 168 citations

Control of the Immune Response at the Level of Antigen-Presenting Cells: A Comparison of the Function of Dendritic Cells and B Lymphocytes

1989 • 163 citations

Immunological adjuvants: Desirable properties and side-effects

1991 • 157 citations

T-cell signaling: The importance of receptor clustering

1997 • 155 citations

A protein particle vaccine containing multiple malaria epitopes

1997 • 150 citations

DNA vaccines

1997 • 149 citations

Macrophages as accessory cells for class I MHC-restricted immune responses.

1991 • 148 citations

Analysis of MHC class II presentation of particulate antigens of B lymphocytes.

1996 • 140 citations

Prospects for adoptive T cell therapy

1997 • 139 citations

Therapeutic antitumor response after immunization with a recombinant adenovirus encoding a model tumor-associated antigen.

1996 • 138 citations

Pneumococcal Vaccine: Clinical Efficacy and Effectiveness

1982 • 134 citations

Measles virus transmembrane fusion protein synthesized de novo or presented in immunostimulating complexes is endogenously processed for HLA class I- and class II-restricted cytotoxic T cell recognition.

1992 • 131 citations

Single immunizing dose of recombinant adenovirus efficiently induces CD8+ T cell-mediated protective immunity against malaria.

1997 • 127 citations

Virus-Like Particles As A Rotavirus Subunit Vaccine

1996 • 123 citations

Processing of exogenous liposome-encapsulated antigens in vivo generates class I MHC-restricted T cell responses.

1992 • 117 citations

IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases.

1995 • 117 citations

Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine.

1992 • 116 citations

Immunoglobulin G and Its Function in the Human Respiratory Tract

1988 • 108 citations

Processing and Presentation of Endocytically Acquired Protein Antigens by MHC Class II and Class I Molecules

1996 • 99 citations

A Leishmania protein that modulates interleukin (IL)‐12, IL‐10 and tumor necrosis factor‐α production and expression of B7‐1 in human monocyte‐derived antigen‐presenting cells

1997 • 99 citations

Immune responses and protection against Bordetella pertussis infection after intranasal immunization of mice with filamentous haemagglutinin in solution or incorporated in biodegradable microparticles

1995 • 96 citations

Comparison of numerous delivery systems for the induction of cytotoxic T lymphocytes by immunization

1996 • 93 citations

Analysis of the role of MHC class II presentation in the stimulation of cytotoxic T lymphocytes by antigens targeted into the exogenous antigen-MHC class I presentation pathway.

1996 • 92 citations

Biodegradable microspheres containing adriamycin in the treatment of proliferative vitreoretinopathy.

1992 • 91 citations

Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo.

1996 • 88 citations

Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors.

1996 • 82 citations

Induction of sustained and elevated immune responses to weakly immunogenic synthetic malarial peptides by encapsulation in biodegradable polymer microspheres

1996 • 82 citations

Synthetic delivery system for tuberculosis vaccines: immunological evaluation of the M. tuberculosis 38 kDa protein entrapped in biodegradable PLG microparticles

1995 • 82 citations

Association of HLA phenotype with response to active specific immunotherapy of melanoma.

1992 • 81 citations

Induction of antigen-specific class I-restricted cytotoxic T cells by soluble proteins in vivo.

1992 • 78 citations

Priming of cytotoxic T lymphocytes by five heat‐aggregated antigens in vivo: Conditions, efficiency, and relation to antibody responses

1997 • 75 citations

Induction of cytotoxic T lymphocytes with peptides in vitro: identification of candidate T-cell epitopes in human papilloma virus.

1992 • 75 citations

MHC class I-restricted presentation of exogenous antigen by thymic antigen-presenting cells in vitro and in vivo.

1992 • 65 citations

Can soluble antigens induce CD8+ cytotoxic T-cell responses? A paradox revisited

1993 • 63 citations

Bone marrow macrophages process exogenous Toxoplasma gondii polypeptides for recognition by parasite-specific cytolytic T lymphocytes.

1993 • 60 citations

The cytoskeleton in mRNA localization and cell differentiation

1997 • 59 citations

Heat-inactivated Sendai virus can enter multiple MHC class I processing pathways and generate cytotoxic T lymphocyte responses in vivo.

1995 • 59 citations

Genetic to genomic vaccination

1997 • 58 citations

Differentiation and Functions of T Cell Subsets

2007 • 54 citations

The theory and practical application of adjuvants

1995 • 53 citations

Functional activity in vivo of effector T cell populations. II. Anti-tumor activity exhibited by syngeneic anti-MoMULV-specific cytolytic T cell clones.

1984 • 53 citations

Cytokine regulation of T-cell function: potential for therapeutic intervention

1993 • 47 citations

The development of new cancer therapies based on the molecular identification of cancer regression antigens.

1995 • 44 citations

Peptide-priming of cytolytic T cell immunity in vivo using beta 2-microglobulin as an adjuvant.

1993 • 41 citations

Antigen processing and intracellular traffic of antigens and MHC molecules

1993 • 41 citations

Accessory Cell Requirements for Saponin Adjuvant-Induced Class I MHC Antigen-Restricted Cytotoxic T-Lymphocytes

1994 • 38 citations

Induction of single and dual cytotoxic T‐lymphocyte responses to viral proteins in mice using recombinant hybrid Ty–virus‐like particles

1996 • 38 citations

Cytokines and clinical gene therapy

1995 • 37 citations

Immunity to infection

1996 • 36 citations

Analysis of the association of peptides of optimal length to class I molecules on the surface of cells.

1992 • 35 citations

Biodegradable microparticles as a delivery system for measles virus cytotoxic T cell epitopes

1996 • 31 citations

Processing of exogenous hepatitis B surface antigen particles for L^d‐restricted epitope presentation depends on exogenous β2‐ microglobulin

1997 • 27 citations

Preparation and characterization of a biodegradable microparticle antigen/cytokine delivery system

1996 • 25 citations

The effects of adjuvants on CTL induction by V3:Ty-virus-like particles (V3-VLPs) in mice

1996 • 14 citations

DRUG CARRIERS IN BIOLOGY AND MEDICINE

1981 • 12 citations

Modern approaches to new vaccines including prevention of AIDS

1989 • 10 citations

Interleukin-12 and up: functions of T helper subsets resulting from differential cytokine production

1997 • 4 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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