Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells

1989 • 1,251 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

1993 • 825 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1994 • 729 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

1990 • 679 citations

Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.

1993 • 612 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.

1991 • 526 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Ability of HIV to Promote a T _H 1 to T _H 0 Shift and to Replicate Preferentially in T _H 2 and T _H 0 Cells

1994 • 482 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.

1995 • 458 citations

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.

1994 • 438 citations

Impaired interleukin 12 production in human immunodeficiency virus-infected patients.

1994 • 435 citations

Cytokine regulation of T-cell function: potential for therapeutic intervention

1993 • 412 citations

Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice.

1994 • 411 citations

Restoration of HIV-Specific Cell-Mediated Immune Responses by Interleukin-12 in Vitro

1993 • 397 citations

Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo.

1983 • 393 citations

Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha

1994 • 374 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells.

1992 • 333 citations

Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice.

1985 • 310 citations

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.

1994 • 305 citations

Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction

1978 • 296 citations

Interleukin‐12 production by human polymorphonuclear leukocytes

1995 • 285 citations

Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites.

1994 • 281 citations

Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

1994 • 276 citations

Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice.

1989 • 275 citations

Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology.

1994 • 274 citations

Toxoplasma gondii induces a T-independent IFN-gamma response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-alpha.

1993 • 271 citations

Response to influenza infection in mice with a targeted disruption in the interferon gamma gene.

1993 • 247 citations

Interleukin‐12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (T_h1) but not on T_h2 cells

1993 • 241 citations

Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction.

1994 • 235 citations

Effects of IL-12 on the response and susceptibility to experimental viral infections.

1994 • 233 citations

Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon

1994 • 223 citations

Interleukin 12 at the site of disease in tuberculosis.

1994 • 218 citations

Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial stimuli

1991 • 215 citations

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.

1995 • 215 citations

CD4+ subset regulation in viral infection. Preferential activation of Th2 cells during progression of retrovirus-induced immunodeficiency in mice.

1992 • 213 citations

Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis.

1994 • 206 citations

Interleukin-12 enhances murine survival against acute toxoplasmosis

1994 • 203 citations

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients.

1992 • 198 citations

Interleukin 12: A key modulator of immune function

1994 • 190 citations

Interleukin 12 induction of interferon gamma-dependent protection against malaria.

1994 • 185 citations

Cytokines in the generation of immune responses to, and resolution of, virus infection

1994 • 185 citations

CD4+ subset expression in murine candidiasis. Th responses correlate directly with genetically determined susceptibility or vaccine-induced resistance.

1993 • 173 citations

A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12.

1995 • 157 citations

Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor

1994 • 153 citations

Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide production by the cytokine-inducible pathway

1994 • 149 citations

CD4+ T cells are required for development of a murine retrovirus-induced immunodeficiency syndrome (MAIDS).

1988 • 147 citations

IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis.

1994 • 140 citations

IL-12 regulates T helper type 1 cytokine responses in human infectious disease.

1994 • 136 citations

Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis

1994 • 133 citations

Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis.

1995 • 126 citations

Interleukin-12 gene expression after viral infection in the mouse

1995 • 119 citations

Interleukin‐12 regulates the proliferation of Th1, but not Th2 or Th0, clones

1994 • 118 citations

Interferon Induces Natural Killer Cell Blastogenesis In Vivo

1984 • 116 citations

Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni.

1994 • 115 citations

IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni.

1994 • 109 citations

In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS).

1994 • 106 citations

Evidence for a protective role of interferon in resistance to murine cytomegalovirus and its control by non-H-2-linked genes

1982 • 102 citations

Interleukin‐12 but not interferon‐γ production correlates with induction of T helper type‐1 phenotype in murine candidiasis

1994 • 85 citations

Infection with Leishmania major induces interleukin-12 production in vivo

1994 • 83 citations

Leishmania donovani infection in scid mice: lack of tissue response and in vivo macrophage activation correlates with failure to trigger natural killer cell-derived gamma interferon production in vitro

1992 • 79 citations

Reconstitution of C.B‐17 scid mice with BALB/c T cells initiates a T helper type‐1 response and renders them capable of healing Leishmania major infection

1993 • 78 citations

Interleukin-12 (IL-12) Augments Cytolytic Activity of Natural Killer Cells Toward Mycobacterium tuberculosis-Infected Human Monocytes

1994 • 64 citations

IL-12 Inhibits Apoptosis Induced in a Human Th1 Clone by gp120/CD4 Cross-Linking and CD3/TCR Activation or by IL-2 Deprivation

1995 • 57 citations

Enumeration of single IFN-gamma-producing cells in mice during viral and bacterial infection.

1989 • 50 citations

Role of Natural Killer Cells in Virus Infections of Mice

1984 • 24 citations

In vivo augmentation of IFN-γ with a rIL-12 human/mouse chimera: Pleiotropic effects against infectious agents in mice and rats

1994 • 15 citations