The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation

SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells

1986 • 391 citations

The role of catalytic superoxide formation in the O2 inhibition of nitroreductase

1975 • 306 citations

The hypoxic tumor cell: A target for selective cancer chemotherapy

1980 • 291 citations

Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells

1987 • 207 citations

Oxygen inhibition of nitroreductase: Electron transfer from nitro radical-anions to oxygen

1976 • 184 citations

Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

1984 • 178 citations

RSU 1069, a nitroimidazole containing an aziridine group

1986 • 104 citations

RSU 1069, a 2-nitroimidazole containing an alkylating group: High efficiency as a radio- and chemosensitizer in vitro and in vivo

1984 • 76 citations

Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins

1989 • 70 citations

Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions

1989 • 64 citations

Structure-activity relationships for benzotriazine DI-N-oxides

1989 • 64 citations

Isolation and characterization of Chinese hamster ovary cell lines sensitive to mitomycin C and bleomycin.

1985 • 56 citations

Mitomycin C is not metabolized by but is an inhibitor of human kidney NAD(P)H:(quinone-acceptor)oxidoreductase

1988 • 49 citations

Isolation of Chinese hamster ovary cell mutants deficient in excision repair and mitomycin C bioactivation.

1989 • 41 citations

The development of hypoxic tumor cell cytotoxic agents

1989 • 6 citations