Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices.

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.

1992 • 814 citations

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 • 800 citations

Metabotropic glutamate receptors in brain function and pathology

1993 • 799 citations

Alzheimer's Disease: A Central Role for Amyloid

1994 • 749 citations

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

1992 • 726 citations

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4

1993 • 585 citations

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1988 • 584 citations

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

1992 • 557 citations

Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells

1992 • 539 citations

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

1993 • 460 citations

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1992 • 455 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease

1995 • 431 citations

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

1993 • 401 citations

The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion

1989 • 355 citations

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein.

1992 • 343 citations

Apolipoprotein E Affects the Rate of Alzheimer Disease Expression: β-Amyloid Burden Is a Secondary Consequence Dependent on APOE Genotype and Duration of Disease

1994 • 332 citations

Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes

1994 • 323 citations

Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor

1989 • 318 citations

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.

1993 • 279 citations

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.

1993 • 236 citations

Cortical Pyramidal Neurone Loss May Cause Glutamatergic Hypoactivity and Cognitive Impairment in Alzheimer's Disease: Investigative and Therapeutic Perspectives

1993 • 233 citations

Serotonin 5-HT2a and 5-HT2c Receptors Stimulate Amyloid Precursor Protein Ectodomain Secretion

1996 • 221 citations

Competitive antagonism at metabotropic glutamate receptors by (S) -4-carboxyphenylglycine and (RS) -α-methyl-4-carboxyphenylglycine

1993 • 219 citations

Muscarinic Regulation of Alzheimer's Disease Amyloid Precursor Protein Secretion and Amyloid β-Protein Production in Human Neuronal NT2N Cells

1995 • 188 citations

Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.

1995 • 182 citations

Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.

1994 • 181 citations

Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.

1993 • 179 citations

Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses

1995 • 175 citations

Regulated secretion of beta-amyloid precursor protein in rat brain

1995 • 157 citations

Inhibition of β‐Amyloid Production by Activation of Protein Kinase C

1993 • 144 citations

Role of Cyclic GMP in the Regulation of Neuronal Calcium and Survival by Secreted Forms of β‐Amyloid Precursor

1995 • 142 citations

Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family

1994 • 139 citations

Pharmacological tools for the investigation of metabotropic glutamate receptors (mGluRs): Phenylglycine derivatives and other selective antagonists—an update

1995 • 99 citations

Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha.

1993 • 96 citations

Pharmacological analysis of 4-carboxyphenylglycine derivatives: Comparison of effects on mGluR1α and mGluR5a subtypes

1995 • 91 citations

Tyrosine Phosphorylation-dependent Stimulation of Amyloid Precursor Protein Secretion by the m3 Muscarinic Acetylcholine Receptor

1995 • 80 citations

The Neurochemistry of Prion Diseases

1993 • 47 citations

Molecular pathogenesis of beta-amyloidosis in Alzheimer's disease and other cerebral amyloidoses.

1995 • 45 citations

N-methyl-D-aspartate increases acetylcholine release from rat striatum and cortex: its effect is augmented by choline.

1992 • 40 citations

Regulation of proteolytic processing of the amyloid beta-protein precursor by first messengers. A novel potential approach for the treatment of Alzheimer's disease.

1995 • 18 citations

Effects of systemic or oral ad libitum monosodium glutamate administration on striatal glutamate release, as measured using microdialysis in freely moving rats

1994 • 16 citations