Platelet secretion induced by phorbol esters stimulation is mediated through phosphorylation of MARCKS: a MARCKS-derived peptide blocks MARCKS phosphorylation and serotonin release without affecting pleckstrin phosphorylation*

Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.

1979 • 1,648 citations

Molecular mechanisms of platelet activation.

1989 • 903 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

The Marcks brothers: A family of protein kinase C substrates

1992 • 474 citations

Chromaffin cell cortical actin network dynamics control the size of the release-ready vesicle pool and the initial rate of exocytosis

1995 • 341 citations

Ca2+ -calmodulin-dependent phosphorylation and platelet secretion

1980 • 274 citations

Calcium/phospholipid regulates phosphorylation of a Mr "87k" substrate protein in brain synaptosomes.

1982 • 257 citations

Myristoylated Alanine-rich C Kinase Substrate (MARCKS) Produces Reversible Inhibition of Phospholipase C by Sequestering Phosphatidylinositol 4,5-Bisphosphate in Lateral Domains

1996 • 223 citations

Cortical filamentous actin disassembly and scinderin redistribution during chromaffin cell stimulation precede exocytosis, a phenomenon not exhibited by gelsolin.

1991 • 223 citations

Signal transduction and the actin cytoskeleton: the roles of MARCKS and profilin

1992 • 203 citations

Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia.

1990 • 195 citations

Phosphorylation and associated translocation of the 87-kDa protein, a major protein kinase C substrate, in isolated nerve terminals.

1989 • 169 citations

Reversible binding of actin to gelsolin and profilin in human platelet extracts.

1987 • 162 citations

Separable assembly of platelet pseudopodal and contractile cytoskeletons

1982 • 140 citations

A discontinuous and highly porous sodium dodecyl sulfate-polyacrylamide slab gel system of high resolution

1988 • 138 citations

Receptors for ADP on human blood platelets

1994 • 130 citations

Phosphorylation-dependent binding of a synthetic MARCKS peptide to calmodulin.

1991 • 126 citations

Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation

1984 • 110 citations

Human platelets contain gelsolin. A regulator of actin filament length.

1982 • 83 citations

Recombinant Scinderin Enhances Exocytosis, an Effect Blocked by Two Scinderin-Derived Actin-Binding Peptides and PIP2

1996 • 80 citations

Glutamate Exocytosis and MARCKS Phosphorylation Are Enhanced by a Metabotropic Glutamate Receptor Coupled to a Protein Kinase C Synergistically Activated by Diacylglycerol and Arachidonic Acid

1994 • 79 citations

Phosphorylation of the Platelet p47 Phosphoprotein Is Mediated by the Lipid Products of Phosphoinositide 3-Kinase

1995 • 75 citations

Recycling of platelet phosphorylation and cytoskeletal assembly.

1984 • 73 citations

Phosphorylation of bovine platelet myosin by protein kinase C

1990 • 71 citations

The cytoskeleton of blood platelets viewed by immunofluorescence microscopy.

1981 • 69 citations

Collagen-induced secretion-dependent phase of platelet aggregation is inhibited by the snake venom metalloproteinase jararhagin

1997 • 66 citations

Protein kinase C activation by phorbol esters induces chromaffin cell cortical filamentous actin disassembly and increases the initial rate of exocytosis in response to nicotinic receptor stimulation

1992 • 58 citations

Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets.

1992 • 58 citations

Recombinant scinderin, an F-actin severing protein, increases calcium- induced release of serotonin from permeabilized platelets, an effect blocked by two scinderin-derived actin-binding peptides and phosphatidylinositol 4,5-bisphosphate

1996 • 51 citations

Activation of Protein Kinase C‐α and Translocation of the Myristoylated Alanine‐Rich C‐Kinase Substrate Correlate with Phorbol Ester‐Enhanced Noradrenaline Release from SH‐SY5Y Human Neuroblastoma Cells

1997 • 50 citations

The Cortical Actin Cytoskeleton of Lactotropes as an Intracellular Target for the Control of Prolactin Secretion*

1997 • 50 citations

Role of actin in platelet function.

1993 • 44 citations

Arginine vasopressin (AVP) causes the reversible phosphorylation of the myristoylated alanine-rich C kinase substrate (MARCKS) protein in the ovine anterior pituitary: evidence that MARCKS phosphorylation is associated with adrenocorticotropin (ACTH) secretion

1994 • 42 citations

Human Platelets Contain Scinderin, a Ca2+-Dependent Actin Filament-Severing Protein

1992 • 34 citations

Protein kinase C-dependent and Ca2+-dependent mechanisms of secretion from streptolysin O-permeabilized platelets: effects of leakage of cytosolic proteins

1997 • 32 citations

Association of coagulation factor V with the platelet cytoskeleton.

1982 • 30 citations

Localization by Segmental Deletion Analysis and Functional Characterization of a Third Actin-binding Site in Domain 5 of Scinderin

1998 • 29 citations

Platelet Activation and Inhibition

1994 • 20 citations

Different Requirement of Intracellular Calcium and Protein Kinase C for Arachidonic Acid Release and Serotonin Secretion in Cathepsin G-activated Platelets

1997 • 18 citations

Correlation between cytosolic Ca2+ concentration, protein phosphorylation and platelet secretion

1996 • 14 citations

Platelet protein phosphorylation and protein kinase C activation by phorbol esters with different biological activity and a novel synergistic response with Ca²⁺ ionophore

1990 • 13 citations

Protein kinase C-dependent and -independent mechanisms of dense granule exocytosis by human platelets

1994 • 12 citations

Regulated Membrane‐Cytoskeleton Linkages in Platelets^a

1994 • 11 citations

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