Characterization of a Conformationally Sensitive Murine Monoclonal Antibody Directed to the Metal Ion-Dependent Adhesion Site Face of Integrin CD11b

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

Leukocyte-endothelial adhesion molecules

1994 • 1,884 citations

Structural Basis of Collagen Recognition by Integrin α2β1

2000 • 945 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1983 • 888 citations

Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells

1990 • 802 citations

Divalent cation regulation of the function of the leukocyte integrin LFA-1.

1992 • 492 citations

A novel divalent cation-binding site in the a domain of the ?2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1993 • 383 citations

Integrin Structure

2000 • 371 citations

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.

1995 • 308 citations

Leukocyte Adhesion Molecules Deficiency: Its Structural Basis, Pathophysiology and Implications for Modulating the Inflammatory Response

1990 • 307 citations

Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol).

1983 • 303 citations

Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion.

1988 • 280 citations

Crystal Structure of the I Domain from Integrin α2β1

1997 • 275 citations

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex

1991 • 270 citations

The Cell-binding Domain of Intimin from Enteropathogenic Escherichia coli Binds to β1 Integrins

1996 • 199 citations

Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18).

1994 • 184 citations

Deficiency of a Granulocyte-Membrane Glycoprotein (gp150) in a Boy with Recurrent Bacterial Infections

1982 • 180 citations

Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies.

1986 • 174 citations

C3bi receptor (complement receptor type 3) recognizes a region of complement protein C3 containing the sequence Arg-Gly-Asp.

1987 • 163 citations

Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA‐1, Mo‐1 and p!50,95

1985 • 162 citations

Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin.

1993 • 144 citations

Conformational changes in tertiary structure near the ligand binding site of an integrin I domain

1999 • 143 citations

An Isoleucine-based Allosteric Switch Controls Affinity and Shape Shifting in Integrin CD11b A-domain

2000 • 142 citations

Differential ligand binding specificities of recombinant CD11b/CD18 integrin I-domain.

1994 • 135 citations

The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

1996 • 134 citations

Analysis of active antibody concentration. Separation of affinity and concentration parameters

1993 • 131 citations

Two Functional States of the CD11b A-Domain: Correlations with Key Features of Two Mn2+-complexed Crystal Structures

1998 • 127 citations

Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain.

1995 • 114 citations

The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF.

1994 • 113 citations

The I Domain of Integrin Leukocyte Function-associated Antigen-1 Is Involved in a Conformational Change Leading to High Affinity Binding to Ligand Intercellular Adhesion Molecule 1 (ICAM-1)

1998 • 101 citations

NMR solution structure of the inserted domain of human leukocyte function associated antigen-1

2000 • 78 citations

Cation binding to the integrin CD11b I domain and activation model assessment

1998 • 73 citations

Crystal structure of the α1β1 integrin I‐domain: insights into integrin I‐domain function

1999 • 64 citations

Solvent-accessible Residues on the Metal Ion-dependent Adhesion Site Face of Integrin CR3 Mediate Its Binding to the Neutrophil Inhibitory Factor

1996 • 57 citations

Cytoplasmic tails of human complement receptor type 3 (CR3, CD11b/ CD18) regulate ligand avidity and the internalization of occupied receptors.

1993 • 55 citations

Cytoplasmic tails of human complement receptor type 3 (CR3, CD11b/CD18) regulate ligand avidity and the internalization of occupied receptors.

1993 • 47 citations

C3bi受容器(3型補体受容器)によるArg‐Gly‐Asp鎖を含むC3領域の認識

1987 • 46 citations

Functional Analysis of the β<sub>2</sub> Integrins

2003 • 11 citations

αMβ2 (CD11b/CD18, Mac-1) integrin activation by a unique monoclonal antibody to αM I domain that is divalent cation-sensitive

2000 • 8 citations

AlphaMbeta2 (CD11b/CD18, Mac-1) integrin activation by a unique monoclonal antibody to alphaM I domain that is divalent cation-sensitive.

2000 • 7 citations