On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion.

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

A two-step mechanism for the interaction of estradiol with rat uterus.

1968 • 1,013 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Induction of β2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferation

1986 • 577 citations

The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

1988 • 522 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Negative Regulation by Glucocorticoids Through Interference with a cAMP Responsive Enhancer

1988 • 502 citations

Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID.

1990 • 501 citations

Corticotropin-Releasing Activity of Monokines

1985 • 500 citations

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene.

1988 • 485 citations

Transcriptional repression of eukaryotic promoters

1989 • 481 citations

Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats

1988 • 428 citations

1,25-Dihydroxyvitamin D-Responsive Element and Glucocorticoid Repression in the Osteocalcin Gene

1989 • 418 citations

Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines.

1990 • 384 citations

Activation of Interleukin-6 Gene Expression through the NF-κB Transcription Factor

1990 • 379 citations

B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells.

1987 • 357 citations

INTERLEUKIN-6 STIMULATES ANTERIOR PITUITARY HORMONE RELEASEIN VITRO.

1989 • 323 citations

Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man.

1989 • 323 citations

The effects of psychological stress on plasma interleukin-6 activity in rats

1990 • 315 citations

Negative regulation of human c-fos expression by thes retinoblastoma gene product

1990 • 298 citations

Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene.

1990 • 283 citations

Production of Interleukin-6 by Folliculo-Stellate Cells of the Anterior Pituitary Gland in a Histiotypic Cell Aggregate Culture System

1989 • 272 citations

Glucocorticoid Receptor Binding to a Specific DNA Sequence Is Required for Hormone-Dependent Repression of Pro-Opiomelanocortin Gene Transcription

1989 • 265 citations

Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP.

1988 • 261 citations

A Cytokine Network in Human Diploid Fibroblasts: Interactions of β-Interferons, Tumor Necrosis Factor, Platelet-Derived Growth Factor, and Interleukin-1

1987 • 261 citations

Cytokine-induced production of IFN-beta 2/IL-6 by freshly explanted human endometrial stromal cells. Modulation by estradiol-17 beta.

1989 • 260 citations

Gene Regulation by Steroid Hormones

1990 • 255 citations

Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus.

1984 • 247 citations

Multiple forms of IFN-beta 2/IL-6 in serum and body fluids during acute bacterial infection.

1989 • 244 citations

Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain

1988 • 238 citations

Interleukin-6 is produced by bone and modulated by parathyroid hormone

1989 • 237 citations

Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene.

1985 • 235 citations

Role of interleukin 6 in fever in rats

1990 • 231 citations

Steroid Hormone Regulation of Gene Expression

1985 • 228 citations

Activation of the human "beta 2-interferon/hepatocyte-stimulating factor/interleukin 6" promoter by cytokines, viruses, and second messenger agonists.

1988 • 215 citations

Human β ₂ Interferon and B-Cell Differentiation Factor BSF-2 Are Identical

1987 • 204 citations

IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans.

1989 • 201 citations

Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of beta 2 interferon by human fibroblasts.

1987 • 199 citations

Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines.

1988 • 183 citations

A Multiple Cytokine- and Second Messenger-Responsive Element in the Enhancer of the Human Interleukin-6 Gene: Similarities with c-fosGene Regulation

1989 • 178 citations

The Role of Interleukin‐6 as the Hepatocyte Stimulating Factor in the Network of Inflammatory Cytokines^a

1989 • 177 citations

A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1.

1987 • 175 citations

Cross-talk in signal transduction: TPA-inducible factor jun/AP-1 activates cAMP-responsive enhancer elements.

1990 • 162 citations

Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription.

1989 • 156 citations

Co-localization of elements required for phorbol ester stimulation and glucocorticoid repression of proliferin gene expression.

1989 • 154 citations

Regulation of the acute phase and immune responses: interleukin-6.

1989 • 151 citations

Transcriptional regulation of the bovine CYP17 (P-450(17)alpha) gene. Identification of two cAMP regulatory regions lacking the consensus cAMP-responsive element (CRE).

1990 • 134 citations

Gene regulation by steroid hormones

1987 • 134 citations

Regulation of the acute phase and immune responses in viral disease. Enhanced expression of the beta 2-interferon/hepatocyte-stimulating factor/interleukin 6 gene in virus-infected human fibroblasts.

1988 • 131 citations

A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation.

1989 • 116 citations

Regulation of Expression of Interleukin‐6

1989 • 95 citations

Eukaryotic Transcriptional Regulatory Proteins

1989 • 93 citations

Dexamethasone inhibits feedback regulation of the mitogenic activity of tumor necrosis factor, interleukin‐1, and epidermal growth factor in human fibroblasts

1987 • 85 citations

Involvement of a NF-κB-Like Transcription Factor in the Activation of the Interleukin-6 Gene by Inflammatory Lymphokines

1990 • 72 citations

Interleukin-6: a regulator of plasma protein gene expression in hepatic and non-hepatic tissues.

1990 • 62 citations

Constitutive and Interleukin-1 (IL-1)-Inducible Factors Interact with the IL-1-Responsive Element in the IL-6 Gene

1990 • 58 citations

Dexamethasone regulation of the expression of cytokine mRNAs induced by interleukin‐1 in the astrocytoma cell line U373MG

1989 • 57 citations

Transcriptionally active immediate-early protein of pseudorabies virus binds to specific sites on class II gene promoters

1989 • 32 citations

Steroid Hormone Regulation of Gene Expression

1985 • 12 citations

The effects of psychological stress and anesthesia on plasma interleukin-6 (IL-6) activity in rat

1989 • 1 citations