Glucocorticoid Suppresses Autocrine Survival of Mast Cells by Inhibiting IL-4 Production and ICAM-1 Expression

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

1989 • 1,199 citations

Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin

1990 • 975 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.

1992 • 727 citations

Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.

1991 • 676 citations

Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1.

1991 • 626 citations

Interleukin 4 is localized to and released by human mast cells.

1992 • 589 citations

Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites

1998 • 568 citations

Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation.

1993 • 561 citations

Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.

1989 • 557 citations

Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals.

1993 • 549 citations

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

1986 • 529 citations

Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.

1991 • 514 citations

Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation

1989 • 494 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA.

1984 • 390 citations

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

1986 • 355 citations

Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma.

1995 • 355 citations

B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells

1987 • 355 citations

Eosinophils, bronchial hyperreactivity and late‐phase asthmatic reactions

1985 • 348 citations

Activated mast cells produce interleukin 13.

1995 • 320 citations

Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type.

1995 • 271 citations

Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis.

1991 • 266 citations

Impaired mucosal immune responses in interleukin 4-targeted mice.

1995 • 227 citations

Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.

1993 • 211 citations

IL-3-dependent murine mast cells undergo apoptosis on removal of IL-3. Prevention of apoptosis by c-kit ligand.

1993 • 195 citations

Immunosuppression by Glucocorticoids: Inhibition of Production of Multiple Lymphokines by in Vivo Administration of Dexamethasone

1993 • 173 citations

Glucocorticoids decrease tissue mast cell number by reducing the production of the c-kit ligand, stem cell factor, by resident cells: in vitro and in vivo evidence in murine systems.

1997 • 154 citations

Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines.

1990 • 149 citations

Glucocorticoids suppress the production of interleukin 4 by human lymphocytes

1991 • 140 citations

Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells.

1996 • 139 citations

Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells

2011 • 130 citations

PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer.

1994 • 123 citations

Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription.

1991 • 112 citations

Interleukin 4 promotes expression of mast cell ICAM-1 antigen.

1991 • 107 citations

Adhesion molecules as regulators of mast-cell and basophil function

1994 • 105 citations

Regulation of the expression of ICAM-1 on human monocytes and monocytic tumor cell lines.

1992 • 99 citations

Human bone marrow non-B, non-T cells produce interleukin 4 in response to cross-linkage of Fc epsilon and Fc gamma receptors.

1991 • 99 citations

Dexamethasone or cyclosporin A suppress mast cell-leukocyte cytokine cascades. Multiple mechanisms of inhibition of IgE- and mast cell-dependent cutaneous inflammation in the mouse.

1995 • 94 citations

T lymphocytes and mast cells express messenger RNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis.

1994 • 94 citations

Effects of interleukin-3 and interleukin-4 on the development of "connective tissue-type" mast cells: interleukin-3 supports their survival and interleukin-4 triggers and supports their proliferation synergistically with interleukin-3

1990 • 90 citations

Regulation of ICAM-1 expression and function in human dermal fibroblasts by IL-4.

1992 • 81 citations

Mast cell adhesion to fibronectin.

1991 • 77 citations

IL-3-dependent mast cells attach to plate-bound vitronectin. Demonstration of augmented proliferation in response to signals transduced via cell surface vitronectin receptors.

1992 • 72 citations

Interleukin-4 Induces Homotypic Aggregation of Human Mast Cells by Promoting LFA-1/ICAM-1 Adhesion Molecules

1997 • 72 citations

Apoptosis in human thymocytes after treatment with glucocorticoids

1992 • 67 citations

Glucocorticoids inhibit the cytokine-induced proliferation of mast cells, the high affinity IgE receptor-mediated expression of TNF-alpha, and the IL-10-induced expression of chymases.

1997 • 65 citations

Preferential expression of interleukin‐12 or interleukin‐4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin‐3

1994 • 61 citations

IL-4 induces LFA-1 and LFA-3 expression on Burkitt's lymphoma cell lines. Requirement of additional activation by phorbol myristate acetate for induction of homotypic cell adhesions.

1989 • 61 citations

Regulation of mediator release from mouse bone marrow-derived mast cells by glucocorticoids.

1985 • 58 citations

Mast cells chemotax to laminin with enhancement after IgE-mediated activation.

1989 • 53 citations

Expression of murine beta 7, alpha 4, and beta 1 integrin genes by rodent mast cells.

1992 • 52 citations

Stimulation of mouse connective tissue-type mast cells by hemopoietic stem cell factor, a ligand for the c-kit receptor.

1992 • 50 citations

The Regulation of Tumor Necrosis Factor-α Production in Murine Mast Cells: Pentoxifylline or Dexamethasone Inhibits IgE-Dependent Production of TNF-α by Distinct Mechanisms

1996 • 38 citations

Modulation of integrin expression during mast cell differentiation

1992 • 36 citations

Costimulation of fibronectin receptor promotes Fc gamma R-mediated rescue of IL-3-dependent bone marrow-derived cells from apoptosis.

1996 • 15 citations

Analysis of cytokine profile in human colonic mucosal FcϵRI‐positive cells by single cell PCR: inhibition of IL‐3 expression in steroid‐treated IBD patients

1997 • 14 citations

FcγRIII-Mediated Regulation of Hematopoiesis in Murine Bone Marrow Cells by Interleukin-3 and CD95 (Fas/Apo-1)

1997 • 5 citations