Requirement for Jak3 in Mature T Cells: Its Role in Regulation of T Cell Homeostasis

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Cytokine receptor signalling

1995 • 1,242 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

1995 • 875 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

Expression of the Fas ligand in cells of T cell lineage.

1995 • 659 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

1989 • 351 citations

The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

1994 • 335 citations

The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques

1996 • 332 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

1996 • 294 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Normal clonal expansion but impaired Fasmediated cell death and anergy induction in interleukin‐2‐deficient mice

1995 • 234 citations

Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids.

1995 • 230 citations

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

1996 • 188 citations

Thymic tumorigenesis induced by overexpression of p56lck.

1991 • 172 citations

Cytokines in T-cell development

1991 • 164 citations

JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells.

1994 • 145 citations

gld/gld mice are unable to express a functional ligand for Fas

1994 • 140 citations

Expression and function of mouse Fas antigen on immature and mature T cells.

1995 • 133 citations

Cytokines and STATs: How can signals achieve specificity?

1995 • 132 citations

Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7.

1995 • 126 citations

Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells.

1994 • 111 citations

Regulation of apoptosis and T cell activation by Fas-specific mAb

1994 • 107 citations

Cytokine production and requirements during T-cell development

1995 • 104 citations

Disruption of thymocyte development and lymphomagenesis induced by SV4O T-antigen

1990 • 91 citations

Cellular aspects of early T-cell development

1992 • 91 citations

Peripheral Expression of Jak3 Is Required to Maintain T Lymphocyte Function

1997 • 89 citations

Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells

1996 • 80 citations

Functional dissection of the murine lck distal promoter.

1995 • 65 citations

Lymphocyte Ontogeny and Activation in Gene Targeted Mutant Mice

1994 • 64 citations

JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering.

1995 • 28 citations