IL-4-DEPENDENT INDUCTION OF BCL-2 AND BCL-XLIN ACTIVATED T LYMPHOCYTES THROUGH A STAT6- AND PI 3-KINASE-INDEPENDENT PATHWAY

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

1998 • 827 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

Current protocols in immunology

1993 • 551 citations

Transcriptional regulation by MAP kinases

1995 • 431 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

Bcl-XL and Bcl-2 repress a common pathway of cell death.

1995 • 406 citations

Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?

1997 • 381 citations

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of Bad phosphorylation

1998 • 308 citations

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4

1997 • 293 citations

Requirements for Interleukin-4-Induced Gene Expression and Functional Characterization of Stat6

1996 • 279 citations

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.

1994 • 257 citations

Lymphocyte lifespans: homeostasis, selection and competition

1993 • 226 citations

Bcl-x_Lcan inhibit apoptosis in cells that have undergone Fas-induced protease activation

1997 • 222 citations

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.

1996 • 194 citations

Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype.

1991 • 180 citations

Hemopoietic Growth Factors with the Exception of Interleukin-4 Activate the p38 Mitogen-activated Protein Kinase Pathway

1997 • 172 citations

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal.

1995 • 167 citations

Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival

1994 • 164 citations

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

1996 • 158 citations

IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway.

1996 • 148 citations

Lymphocyte homeostasis

1997 • 133 citations

The life span of naive alpha/beta T cells in secondary lymphoid organs.

1993 • 130 citations

Signaling via IL-2 and IL-4 in JAK3-Deficient Severe Combined Immunodeficiency Lymphocytes: JAK3-Dependent and Independent Pathways

1996 • 129 citations

IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors.

1997 • 106 citations

Interleukin 4 signals through two related pathways.

1995 • 90 citations

Interaction of the c-fes proto-oncogene product with the interleukin-4 receptor

1994 • 84 citations

c-Cbl Is Tyrosine-Phosphorylated by Interleukin-4 and Enhances Mitogenic and Survival Signals of Interleukin-4 Receptor by Linking With the Phosphatidylinositol 3′-Kinase Pathway

1998 • 84 citations

Interleukin-4-dependent proliferation dissociates p44erk-1, p42erk-2, and p21ras activation from cell growth.

1994 • 78 citations

Identification of an essential region for growth signal transduction in the cytoplasmic domain of the human interleukin-4 receptor

1992 • 75 citations

The IL-4 receptor alpha-chain cytoplasmic domain is sufficient for activation of JAK-1 and STAT6 and the induction of IL-4-specific gene expression.

1997 • 69 citations

Intermediate Affinity Interleukin-2 Receptor Mediates Survival via a Phosphatidylinositol 3-Kinase-dependent Pathway

1997 • 67 citations

Regulation of apoptosis by tyrosine-containing domains of IL-4R alpha: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis.

1998 • 59 citations

T-B cell interaction inhibits spontaneous apoptosis of mature lymphocytes in Bcl-2-deficient mice.

1995 • 53 citations

Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells.

1997 • 53 citations

Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.

1994 • 47 citations

Interleukin-4 Induces Activation of Mitogen-activated Protein Kinase and Phosphorylation of Shc in Human Keratinocytes

1996 • 42 citations

Interleukin-4

1990 • 41 citations

Requirement for Jak3 in Mature T Cells: Its Role in Regulation of T Cell Homeostasis

1998 • 40 citations

Regulation of Apoptosis by Tyrosine-Containing Domains of IL-4Rα: Y497 and Y713, But Not the STAT6-Docking Tyrosines, Signal Protection from Apoptosis

1998 • 38 citations

Lessons from Immunological, Biochemical, and Molecular Pathways of the Activation Mediated by IL-2 and IL-4

1996 • 31 citations

Measurement of Human and Murine Interleukin 2 and Interleukin 4

2000 • 22 citations

Independent pathways for de-repression of the mouse Ig heavy chain germ-line ε promoter: an IL-4 NAF/NF-IL-4 site as a context-dependent negative element

1996 • 21 citations

Receptors That Regulate T‐Cell Susceptibility to Apoptotic Cell Death

1995 • 21 citations

Role of p70 S6 kinase in cytokine-regulated hemopoietic cell survival

1996 • 19 citations

Interleukin-4 Activates Two Distinct Pathways of Phosphatidylinositol-3 Kinase in the Same Cells

1996 • 13 citations

Introduction of the cell survival gene bcl-xL improves the viability of CTLL-2 cells without affecting their IL-2 proliferative response Implications for the development of bioassays

1996 • 9 citations

The Immunophilin Ligand Rapamycin: A Probe for the Analysis of the Relationship of Apoptosis to the Cell Cycle

1996 • 1 citations