Repression of IL-4-induced gene expression by IFN-gamma requires Stat1 activation.

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

STATs and Gene Regulation

1997 • 3,927 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Cytokine signal transduction

1994 • 1,358 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Cytokine receptor signalling

1995 • 1,242 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

1988 • 939 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

Twenty proteins containing a C-terminal SOCS box form five structural classes

1998 • 735 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product

1995 • 604 citations

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

1995 • 423 citations

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

1993 • 411 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?

1997 • 381 citations

Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression.

1994 • 334 citations

Requirements for Interleukin-4-Induced Gene Expression and Functional Characterization of Stat6

1996 • 279 citations

Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4

1993 • 256 citations

Components of a stat recognition code: Evidence for two layers of molecular selectivity

1995 • 254 citations

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.

1995 • 201 citations

IL-4 and IL-13 receptors: are they one and the same?

1996 • 188 citations

A Janus Kinase Inhibitor, JAB, Is an Interferon-γ–Inducible Gene and Confers Resistance to Interferons

1998 • 172 citations

IL-4-induced STAT6 suppresses IFN-gamma-stimulated STAT1-dependent transcription in mouse macrophages.

1997 • 162 citations

Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of Stat1

1996 • 153 citations

Regulation of human IgE synthesis. I. Human IgE synthesis in vitro is determined by the reciprocal antagonistic effects of interleukin 4 and interferon‐γ

1990 • 139 citations

SOCS-1/JAB/SSI-1 Can Bind to and Suppress Tec Protein-tyrosine Kinase

1997 • 117 citations

SOCS: suppressors of cytokine signalling

1998 • 108 citations

IFN-γ represses ε germline transcription and subsequently down-regulates switch recombination to ε

1994 • 96 citations

Modulation of IL‐4‐induced human IgE production in vitro by IFN‐γ and IL‐5: The role of soluble CD23 (s‐CD23)

1989 • 80 citations

IFN-gamma and IL-10 inhibit induction of IL-1 receptor type I and type II gene expression by IL-4 and IL-13 in human monocytes.

1997 • 79 citations

Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1

1997 • 70 citations

Activation of Lyn, Blk, and Btk But Not Syk in CD72-Stimulated B Lymphocytes

1998 • 51 citations

Regulation of Human IgE synthesis

1991 • 51 citations

Differentiation of T‐helper lymphocytes: selective regulation by members of the STAT family of transcription factors

1996 • 13 citations