Apoptotic signaling during initiation of detachment-induced apoptosis ("anoikis") of primary human intestinal epithelial cells.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Caspases: the proteases of the apoptotic pathway

1998 • 1,048 citations

An Induced Proximity Model for Caspase-8 Activation

1998 • 1,030 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Cadherins in cancer: implications for invasion and metastasis

1993 • 939 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis

1999 • 829 citations

Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

1994 • 820 citations

Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

1997 • 615 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.

1994 • 504 citations

Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis

1998 • 496 citations

Caspase-dependent Cleavage of Signaling Proteins during Apoptosis

1998 • 420 citations

In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death.

1995 • 416 citations

Apoptosis Induction by Caspase-8 Is Amplified through the Mitochondrial Release of Cytochrome c

1998 • 380 citations

Cell Death by Apoptosis in Epidermal Biology

1993 • 296 citations

Cadherins and catenins: role in signal transduction and tumor progression.

1999 • 290 citations

Death by a thousand cuts: an ever increasing list of caspase substrates

1998 • 286 citations

Caspase-mediated Cleavage of Focal Adhesion Kinase pp125FAK and Disassembly of Focal Adhesions in Human Endothelial Cell Apoptosis

1998 • 258 citations

Differentiation and self-renewal in the mouse gastrointestinal epithelium

1994 • 256 citations

A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA.

1996 • 250 citations

Different Subcellular Distribution of Caspase-3 and Caspase-7 following Fas-induced Apoptosis in Mouse Liver

1998 • 236 citations

Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis

1999 • 209 citations

Widespread histologic distribution of the alpha 2 beta 1 integrin cell-surface collagen receptor.

1990 • 183 citations

Differential expression of the VLA family of integrins along the crypt-villus axis in the human small intestine

1992 • 176 citations

Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis

1999 • 172 citations

Expression of VLA-alpha 2, VLA-alpha 6, and VLA-beta 1 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastases.

1991 • 166 citations

Rapid onset of apoptosis in vitro follows disruption of beta 1- integrin/matrix interactions in human colonic crypt cells

1996 • 162 citations

Focal adhesion kinase and its potential involvement in tumor invasion and metastasis

1998 • 159 citations

1-Methyl-4-Phenylpyridinium Induces Autocrine Excitotoxicity, Protease Activation, and Neuronal Apoptosis

1998 • 154 citations

Loss of Matrix Adhesion Triggers Rapid Transformation-Selective Apoptosis in Fibroblasts

1997 • 135 citations

Dephosphorylation of Focal Adhesion Kinase (FAK) and Loss of Focal Contacts Precede Caspase-mediated Cleavage of FAK during Apoptosis in Renal Epithelial Cells

1999 • 127 citations

In situ detection of enterocytic apoptosis in normal colonic mucosa and in familial adenomatous polyposis.

1995 • 124 citations

Sequential and rapid activation of select caspases during apoptosis of normal intestinal epithelial cells

1998 • 119 citations

New Isolation Technique to Study Apoptosis in Human Intestinal Epithelial Cells

1998 • 119 citations

Lack of Correlation between Activation of Jun–NH2-terminal Kinase and Induction of Apoptosis after Detachment of Epithelial Cells

1997 • 118 citations

Ultrastructure of cell loss in intestinal mucosa

1977 • 116 citations

Extracellular matrix remodeling and the regulation of epithelial-stromal interactions during differentiation and involution.

1996 • 100 citations

Modulation of Apoptotic Cell Death by Extracellular Matrix Proteins and a Fibronectin-Derived Antiadhesive Peptide

1998 • 99 citations

Identification of programmed cell death in normal human skin tissues by using specific labelling of fragmented DNA

2006 • 95 citations

Expression of J1 / ten asci n in the crypt-villus unit of adult mouse small intestine: implications for its role in epithelial cell shedding

1990 • 80 citations

Cell-matrix and cell-cell interactions modulate apoptosis of bronchial epithelial cells

1997 • 73 citations

Hierarchical cleavage of focal adhesion kinase by caspases alters signal transduction during apoptosis of intestinal epithelial cells

2001 • 60 citations

Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lymphocytic leukemia cells

1998 • 50 citations

E-Cadherin Engagement Stimulates Tyrosine Phosphorylation

1997 • 47 citations

Release of mitochondrial cytochrome c is upstream of caspase activation in chemical-induced apoptosis in human monocytic tumour cells

1998 • 35 citations

Unique Features of Antigen Presentation in the Intestinea

1992 • 27 citations

Apoptosis induced by denied adhesion to extracellular matrix (anoikis) in thyroid epithelial cells is p53 dependent but fails to correlate with modulation of p53 expression

1999 • 27 citations

Functional Dissociation of Anoikis-like Cell Death and Activity of Stress Activated Protein Kinase

1999 • 18 citations

Induction and altered distribution of tenascin in the basal lamina of colorectal adenomas and carcinomas

1992 • 6 citations