Dietary calorie restriction in the Emory mouse: effects on lifespan, eye lens cataract prevalence and progression, levels of ascorbate, glutathione, glucose, and glycohemoglobin, tail collagen breaktime, DNA and RNA oxidation, skin integrity, fecundity, and cancer

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Ascorbate is an outstanding antioxidant in human blood plasma.

1989 • 1,876 citations

THE DETERMINATION OF ASCORBIC ACID IN WHOLE BLOOD AND URINE THROUGH THE 2,4-DINITROPHENYLHYDRAZINE DERIVATIVE OF DEHYDROASCORBIC ACID

1943 • 1,810 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

1986 • 968 citations

Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

1982 • 757 citations

Nutritional Influences on Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteristics

1985 • 587 citations

High-performance liquid chromatography of thiols and disulfides: Dinitrophenol derivatives

1987 • 504 citations

Modern Biological Theories of Aging

1989 • 469 citations

Biochemistry of the Eye

1991 • 444 citations

The maillard reaction in aging, diabetes and nutrition

1990 • 376 citations

Protein oxidative damage is associated with life expectancy of houseflies.

1993 • 347 citations

Nonenzymatic Glycosylation, the Maillard Reaction and the Aging Process

1990 • 335 citations

Minireview: Food Restriction in Rodents: An Evaluation of Its Role in the Study of Aging

1988 • 322 citations

Oxygen Radicals in Biology and Medicine

1988 • 293 citations

Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column.

1992 • 292 citations

Influences of Dietary Restriction and Age on Liver Enzyme Activities and Lipid Peroxidation in Mice

1987 • 280 citations

Modern Biological Theories of Aging

1987 • 274 citations

Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention

1991 • 265 citations

Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat

1989 • 251 citations

High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis.

1991 • 250 citations

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories.

1992 • 248 citations

Oxidation of glycated proteins: age-dependent accumulation of N.epsilon.-(carboxymethyl)lysine in lens proteins

1989 • 239 citations

Preparation and Use of a Boronic Acid Affinity Support for Separation and Quantitation of Glycosylated Hemoglobins

1981 • 216 citations

The calorically restricted low-fat nutrient-dense diet in Biosphere 2 significantly lowers blood glucose, total leukocyte count, cholesterol, and blood pressure in humans.

1992 • 209 citations

Free Radicals in Molecular Biology, Aging, and Disease

1985 • 203 citations

Protein oxidation and loss of protease activity may lead to cataract formation in the aged lens

1987 • 196 citations

A Distribution-Free Test for Tumor-Growth Curve Analyses with Application to an Animal Tumor Immunotherapy Experiment

1981 • 172 citations

Protection of DNA damage by dietary restriction

1992 • 161 citations

Evidence for the Glycation Hypothesis of Aging From the Food-Restricted Rodent Model

1989 • 147 citations

Biological Effects of Dietary Restriction

1991 • 144 citations

Toward a Maillard reaction theory of aging.

1989 • 142 citations

[Free radicals and aging].

1990 • 136 citations

Immunoaffinity isolation of urinary 8-hydroxy-2′-deoxygunosine and 8-hydroxyguanine and quantitation of 8-hydroxy-2′deoxyguanosine in DNA by polyclonal antibodies

1991 • 135 citations

Effect of chronic food restriction in aging rats II. Liver cytosolic antioxidants and related enzymes

1989 • 127 citations

Genetic Differences in Effects of Food Restriction on Aging in Mice

1987 • 126 citations

Relationship in humans between ascorbic acid consumption and levels of total and reduced ascorbic acid in lens, aqueous humor, and plasma

1991 • 122 citations

Isolation and characterization of a blue fluorophore from human eye lens crystallins: In vitro formation from Maillard reaction with ascorbate and ribose

1992 • 115 citations

Oxygen radicals in biology and medicine

1989 • 112 citations

The Effect of Dietary Restriction of Varying Duration on Survival, Tumor Patterns, Immune Function, and Body Temperature in B10C3F1 Female Mice

1983 • 107 citations

The role of ascorbic acid in senile cataract.

1985 • 105 citations

Cellular and molecular mechanisms of aging

1993 • 102 citations

Ascorbic acid in lymphocytes: cell preparation and liquid-chromatographic assay.

1982 • 96 citations

Effect of Chronic Caloric Restriction on the Synchronization of Various Physiological Measures in Old Female Fischer 344 Rats

1990 • 90 citations

Relationship between Dietary Intake and Tissue Levels of Reduced and Total Vitamin C in the Nonscorbutic Guinea Pig

1989 • 85 citations

Delay of uv-induced eye lens protein damage in guinea pigs by dietary ascorbate

1986 • 79 citations

Glycation of lens proteins by the oxidation products of ascorbic acid

1990 • 78 citations

Oxidation and Aging: Impact on Vision

1993 • 67 citations

Moderate caloric restriction delays cataract formation in the Emory mouse

1989 • 65 citations

The Emory mouse cataract: An animal model for human senile cataract

1981 • 62 citations

Induction of cataracts in mice by exposure to oxygen.

1972 • 59 citations

Role of Nutrients in Delaying Cataracts^a

1992 • 59 citations

Effect of Dietary Ascorbic Acid Intake on Tissue Vitamin C in Mice

1987 • 55 citations

Beyond deficiency : new views on the function and health effects of vitamins

1992 • 52 citations

Modification of proteins during aging.

1986 • 50 citations

Measures of leucine aminopeptidase can be used to anticipate UV-induced age-related damage to lens proteins: Ascorbate can delay this damage

1987 • 48 citations

Late onset hereditary cataract of the Emory mouse. A model for human senile cataract

1990 • 48 citations

In vitro non-enzymatic glycation and formation of browning products in the bovine lens α-crystallin

1990 • 48 citations

Longevity‐Assurance Mechanisms and Caloric Restriction

1991 • 46 citations

Influence of Life-Prolonging Food Restriction on Membrane Lipoperoxidation and Antioxidant Status

1988 • 44 citations

Measurement of changes in mouse tail collagen with age: Temperature dependence and procedural details

1978 • 40 citations

Free Radicals and Aging

1992 • 39 citations

Reduced and total ascorbate in guinea pig eye tissues in response to dietary intake

1988 • 38 citations

Tail collagen aging in mice of thirteen different genotypes and two species: Relationship to biological age

1978 • 36 citations

Dietary Restriction Retards Age-Related Loss of Gamma Crystallins in the Mouse Lens

1984 • 35 citations

Mechanism of Food Restriction: Protection of Cellular Homeostasis

1990 • 33 citations

Biological Effects of Dietary Restriction

1990 • 31 citations

Aging effects of vitamin C on a human lens protein produced in vitro

1987 • 29 citations

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories

1992 • 27 citations

Characterization of age-related malondialdehyde oxidation: the effect of modulation by food restriction

1989 • 26 citations

Cataract incidence and analysis of lens crystallins in the water-, urea-and SDS-soluble fractions of Emory mice fed a diet restricted by 40% in calories

1993 • 25 citations

Dietary Energy Restriction Decreases Ex Vivo Spleen Prostaglandin E2 Synthesis in Emory Mice

1990 • 23 citations

Chronic Caloric Restriction in Old Female Mice: Changes in the Circadian Rhythms of Physiological and Behavioral Variables

1991 • 23 citations

Dietary restriction and the aging process

1984 • 22 citations

Prevention of cancer: Restriction of nutritional energy intake (joules)

1988 • 21 citations

Senile cataract and ascorbic acid loading

1985 • 19 citations

Non-enzymatic glycosylation of fibrous and basement membrane collagens.

1989 • 18 citations

Glutathione metabolism in lenses of Emory and cataract-resistant mice: activity of five enzymes

1986 • 15 citations

Physiological senescence and its postponement : theoretical approaches and rational interventions

1991 • 15 citations

Effect of photooxidation on the eye lens and role of nutrients in delaying cataract

1992 • 9 citations

Physiology of Ageing: Nutritional Aspects

1990 • 8 citations

Deleted Work

1955 • 0 citations