Aging, Dietary Restriction, and Glucocorticoids: A Critical Review of the Glucocorticoid Hypothesis

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*

1986 • 2,235 citations

Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging

1985 • 1,129 citations

Glucocorticoids Potentiate Ischemic Injury to Neurons: Therapeutic Implications

1985 • 677 citations

Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain After Adrenalectomy

1989 • 520 citations

Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments

1981 • 519 citations

Hippocampal Aging and Adrenocorticoids: Quantitative Correlations

1978 • 486 citations

A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults

1985 • 406 citations

Food and Water Restriction Shifts Corticosterone, Temperature, Activity and Brain Amine Periodicity

1974 • 379 citations

Glucocorticoid Inhibition of Glucose Uptake by Peripheral Tissues: Old and New Evidence, Molecular Mechanisms, and Physiological Significance

1971 • 347 citations

Dietary Restriction Benefits Learning and Motor Performance of Aged Mice

1987 • 341 citations

The adrenocorticol stress-response in the aged male rat: Impairment of recovery from stress

1983 • 288 citations

Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels

1986 • 288 citations

Patterns of Astroglial Hypertrophy and Neuronal Degeneration in the Hippocampus of Aged, Memory-deficient Rats

1977 • 219 citations

Life Stress and Illness

1974 • 201 citations

Glucocorticoid toxicity in the hippocampus: Temporal aspects of neuronal vulnerability

1985 • 182 citations

Elevated Corticosterone Levels

1984 • 154 citations

Glucocorticoid Toxicity in the Hippocampus

1986 • 152 citations

HISTOLOGICAL CHANGES IN THE ORGANS AND TISSUES OF MIGRATING AND SPAWNING PACIFIC SALMON (GENUS ONCORHYNCHUS)¹

1960 • 146 citations

Dietary Restriction Retards the Age-Associated Loss of Rat Striatal Dopaminergic Receptors

1981 • 138 citations

Chronic Stress Effects on Adrenocortical Responsiveness in Young and Aged Rats

1973 • 130 citations

Spontaneous arteriosclerosis in repeatedly bred male and female rats

1964 • 130 citations

LIFE STRESS AND ILLNESS

1975 • 120 citations

Critical role of food amount for prefeeding corticosterone peak in rats

1983 • 120 citations

Delayed loss of striatal dopamine receptors during aging of dietarily restricted rats

1984 • 107 citations

Diminished Diurnal Secretion of Adrenocorticotropin (ACTH), But Not Corticosterone, in Old Male Rats: Possible Relation to Increased Adrenal Sensitivity to ACTHin Vivo*

1987 • 105 citations

Hypothalamus Pituitary and Aging.

1977 • 98 citations

Biological Mechanisms of Aging

1963 • 95 citations

Chronic Food Restriction and the Circadian Rhythms of Pituitary-Adrenal Hormones, Growth Hormone and Thyroid-Stimulating Hormone

1987 • 94 citations

Hypothalamus Pituitary and Aging

1977 • 94 citations

Dietary restriction: effects on radial maze learning and lipofuscin pigment deposition in the hippocampus and frontal cortex

1987 • 93 citations

Morphologische Ver�nderungen im Diencephalon und Telencephalon nach St�rungen des Regelkreises Adenohypophyse-Nebennierenrinde

1968 • 91 citations

Big-bang reproduction and ageing in male marsupial mice

1982 • 87 citations

Adrenocortical Responsiveness to Stress and ACTH in Aging Rats

1970 • 86 citations

Some age-related changes in pituitary-adrenal function in the male laboratory rat.

1978 • 84 citations

The Effects of Acute and Life-Long Food Restriction on Basal and Stress-Induced Serum Corticosterone Levels in Young and Aged Rats*

1988 • 81 citations

Relationship between Circadian Rhythm of Food Intake and that of Plasma Corticosterone and Effect of Food Restriction on Circadian Adrenocortical Rhythm in the Rat

1977 • 80 citations

SERUM CORTICOTROPHIN, PLASMA CORTISOL AND URINARY EXCRETION OF 17-KETOGENIC STEROIDS IN THE ELDERLY (AGE GROUP: 66–94 YEARS)

1971 • 62 citations

Effects of lifelong restricted feeding on complex maze performance in rats

1984 • 58 citations

Hormones in development and aging

1983 • 56 citations

Pituitary Degeneration and Adrenal Tissue Hyperplasia in Spawning Pacific Salmon

1957 • 55 citations

Mammalian aging: Theoretical implications of changes in brain and endocrine systems during mid- and late-life in rats

1980 • 54 citations

Role of the neurohypophysis in the pathogenesis of hypertension and some allied disorders associated with aging

1949 • 53 citations

Adrenocortical function in arteriosclerotic female breeder rats

1965 • 50 citations

Effects of long-term restricted feeding on radial maze performance by aged rats

1987 • 49 citations

Differential Effects of Aging on Adrenocdrticotropin Receptors, Adenosine 3′5′-Monophosphate Response, and Corticosterone Secretion in Adrenocortical Cells from Sprague-Dawley Rats*

1986 • 49 citations

Aging of the Rat Adrenocortical Cell: Response to Acth and Cyclic Amp in Vitro

1983 • 49 citations

Effects of chronic ACTH stimulation on adrenocortical function in young and aged rats

1972 • 44 citations

Reduced Ability of Old Male Rats to Release Acth and Corticosterone in Response to CRF Administration

1984 • 43 citations

Serum lipoprotein and lipid changes in arteriosclerotic breeder rats

1964 • 39 citations

EFFECTS OF STARVATION ON LEVELS OF CORTICOTROPHIN RELEASING FACTOR, CORTICOTROPHIN AND PLASMA CORTICOSTERONE IN RATS

1969 • 37 citations

Circulating Corticosterone Levels of Young and Old, Male and Female C57B1/6J Mice

1968 • 33 citations

Hormones in Development and Aging

1981 • 32 citations

The Effect of Chronic Environmental Stress on Premature Aging in the Rat

1965 • 29 citations

Changes in adrenocortical function during aging in cattle.

1967 • 26 citations

Benzodiazepine-like behavioral effects following withdrawal from chronic delta-9-tetrahydrocannabinol administration in rats.

1989 • 21 citations

Aging and adrenal cortical hormones.

1952 • 21 citations

Effect of Aging on the Steroid Metabolism as Reflected in Plasma Levels

1956 • 19 citations

Interaction of Aging with <i>in vitro </i>Adrenocortical Responsiveness to ACTH and Cyclic AMP

1979 • 19 citations

Changes in Adrenocortieal Responsiveness to ACTH Infusion in Aging Goats

1968 • 18 citations

Biological Mechanisms of Aging

2018 • 15 citations

Inhibition of spontaneously developing arteriosclerosis in female breeder rats by adrenalectomy

1977 • 11 citations

Effects of Starvation on Adrenal Cortical Function in the Rabbit

1970 • 9 citations

Reproduction and Aging.

1975 • 8 citations

Cushingoid Pathophysiology of Old, Massively Obese, Spontaneously Hypertensive Rats (shr)

1983 • 8 citations

Factors affecting the metabolism and distribution of cortisol as measured by levels of 17-Hydroxycorticosteroids in blood

1957 • 6 citations

Ameliorative effects of adrenalectomy on the hyperphagia, hyperlipidaemia, hyperglycaemia and hypertension of obese, spontaneously hypertensive rats (Obese/SHR).

1981 • 5 citations

Hyperlipidemia, hyperglycemia and hypertension in repeatedly bred parents of the obese spontaneously hypertensive rat (Obese/SHR) unaccompanied by arteriosclerosis

1984 • 3 citations