Life-long moderate caloric restriction prolongs reproductive life span in rats without interrupting estrous cyclicity: effects on the gonadotropin-releasing hormone/luteinizing hormone axis

The Physiology of Reproduction

1988 • 7,765 citations

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

1935 • 2,189 citations

Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection

1986 • 888 citations

Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats

1990 • 648 citations

A rapid and simple procedure for chronic cannulation of the rat jugular vein.

1974 • 646 citations

Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus

1988 • 510 citations

The Physiology of Gonadotropin-Releasing Hormone (GnRH) Secretion in Men and Women

1985 • 489 citations

Luteinizing Hormone-Releasing Hormone Release during the Rat Estrous Cycle and after Ovariectomy, as Estimated with Push-Pull Cannulae*

1982 • 407 citations

Ovarian and Steroidal Influences on Neuroendocrine Aging Processes in Female Rodents*

1984 • 267 citations

Relationships among Weight Gains, Age at Puberty and Reproductive Performance in Heifers

1971 • 262 citations

Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats.

1985 • 257 citations

Effect of Restricted Nutrition on Puberty in the Lamb: Patterns of Tonic Luteinizing Hormone (LH) Secretion and Competency of the LH Surge System*

1985 • 252 citations

Food-Restricted, Prepubertal, Female Rats: Rapid Recovery of Luteinizing Hormone Pulsing with Excess Food, and Full Recovery of Pubertal Development with Gonadotropin-Releasing Hormone*

1986 • 206 citations

Energy metabolism and aging: a lifelong study of Fischer 344 rats

1992 • 202 citations

Increased hypothalamic neuropeptide Y expression following food deprivation

1990 • 193 citations

Nutrition and Longevity in the Rat

1960 • 184 citations

Onset of puberty and duration of fertility in rats fed a restricted diet

1979 • 183 citations

Low Dose Pulsatile Gonadotropin-Releasing Hormone in Anorexia Nervosa: A Model of Human Pubertal Development*

1979 • 157 citations

Effect of Dietary Restriction on Estrous Cyclicity and Follicular Reserves in Aging C57BL/6J Mice 1

1985 • 139 citations

Influence of Food Restriction on Neuropeptide-Y, Proopiomelanocortin, and Luteinizing Hormone-Releasing Hormone Gene Expression in Sheep Hypothalami1

1993 • 137 citations

Neuropeptide Y Enhances the Release of Luteinizing Hormone (LH) Induced by LH-Releasing Hormone*

1987 • 136 citations

EVIDENCE THAT NEUROPEPTIDE Y (NPY) RELEASED INTO THE HYPOPHYSIAL-PORTAL CIRCULATION PARTICIPATES IN PRIMING GONADOTROPES TO THE EFFECTS OF GONADOTROPIN RELEASING HORMONE (GnRH)

1988 • 124 citations

Energy Intake, Body Composition and Reproductive Performance of the Gilt

1985 • 114 citations

Neuroendocrine Control of the Ovarian Cycle of the Rat

2014 • 111 citations

Restoration of ovulatory cycles by young ovarian grafts in aging mice: potentiation by long-term ovariectomy decreases with age.

1983 • 107 citations

THE EFFECTS OF DIETARY CALORIC RESTRICTION ON MATURITY AND SENESCENCE, WITH PARTICULAR REFERENCE TO FERTILITY AND LONGEVITY

1947 • 103 citations

Preproneuropeptide Y Messenger Ribonucleic Acid in the Hypothalamic Arcuate Nucleus of the Rat is Increased by Food Deprivation or Dehydration

1991 • 98 citations

Aging, Nutrition and Hepatic Enzyme Activity Patterns in the Rat

1969 • 96 citations

Age-Related Changes in Pulsatile Luteinizing Hormone Release Precede the Transition to Estrous Acyclicity and Depend upon Estrous Cycle History*

1990 • 93 citations

High Concentrations of Neuropeptide Y in Pituitary Portal Blood of Rats

1987 • 87 citations

Suppression of gonadotropin secretion and prevention of ovulation in the rat by antiserum to synthetic gonadotropin-releasing hormone

1973 • 73 citations

Regulation of Ovarian and Testicular Function

1987 • 70 citations

Adaptation of muscle glucose transport with caloric restriction in adult, middle-aged, and old rats

1994 • 69 citations

Evidence for a Direct Action of Neuropeptide Y in the Rat Pituitary Gland

1988 • 67 citations

Reinitiation of Gonadotropin Release in Underfed Rats by Constant Light or Epinephrine¹

1967 • 64 citations

Mechanisms of Caloric Restriction Affecting Aging and Disease^a

1994 • 61 citations

Modification of the oestrous cycle hormonal profile by dietary restriction

1985 • 51 citations

The Effect of Restricted Food Intake on the Size and Composition of the Ovarian Follicle Population in the Wistar Rat

1978 • 50 citations

Role of hypothalamic neuropeptide Y gene expression in body weight regulation

1994 • 49 citations

The Effect of Retarded Growth Upon the Sexual Development of Rats

1935 • 37 citations

Changes in the characteristics of pulsatile luteinizing hormone secretion during the oestrous cycle and after ovariectomy and oestrogen treatment in female rats

1982 • 35 citations

Regulation of luteinizing hormone secretion by neuropeptide Y in rats: Hypothalamic and pituitary actions

1988 • 33 citations

Aging, Nutrition and Hepatic Enzyme Activity Patterns in the Rat

1969 • 30 citations

Kinetic Aspects of Follicular Development in the Rat

1987 • 29 citations

Growth and Sexual Maturation in Ewes: Dietary and Seasonal Effects Modulating Luteinizing Hormone Secretion and First Ovulation

1982 • 28 citations

Age-Related Alterations in Pulsatile Luteinizing Hormone Release: Effects of Long-Term Ovariectomy, Repeated Pregnancies and Naloxone1

1988 • 27 citations

ASSESSMENT OF GONADOTROPHIN SECRETION IN WOMEN WITH ANOREXIA NERVOSA

1975 • 24 citations

Effects of Dietary Energy on Ovarian Function, Estrogen Suppression of Luteinizing Hormone and Follicle-Stimulating Hormone, and Competency of the Gonadotropin Surge1

1991 • 19 citations

Delay of senescence infertility by dietary restriction.

1949 • 16 citations

The effect of restricted food intake and refeeding on the ovarian follicle population of the pre-puberal Wistar rat

1981 • 15 citations

Diet Restriction Prevents Aging-Induced Deficits in Brain Phosphoinositide Metabolism

1993 • 10 citations

A Dietary Key to Uncovering Aging Processes

1992 • 8 citations

Effect of a restricted diet on the in vitro glucose-induced insulin release of aging rats

1992 • 7 citations

Effect of neonatal undernutrition on serum follicle-stimulating hormone levels and ovarian development in the female rat

1980 • 6 citations