Tumor Physiology and Resistance to Chemotherapy: Repopulation and Drug Penetration

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

Acid pH in tumors and its potential for therapeutic exploitation.

1989 • 1,633 citations

The hazard of accelerated tumor clonogen repopulation during radiotherapy

1988 • 1,592 citations

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

1997 • 1,590 citations

Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.

1997 • 1,510 citations

Transport of molecules in the tumor interstitium: a review.

1987 • 1,360 citations

A Southwest Oncology Group study

1993 • 778 citations

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

1968 • 764 citations

Observations on growth rates of human tumors.

1956 • 759 citations

Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: a randomised multicentre trial

1997 • 590 citations

Matrix metalloproteinase inhibitors

1997 • 509 citations

A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer

1997 • 477 citations

Tumor size, sensitivity to therapy, and design of treatment schedules.

1977 • 442 citations

The Norton-Simon hypothesis revisited.

1986 • 415 citations

The effect of treatment duration in the local control of cervix cancer

1992 • 383 citations

Impact of the cyclin–dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents

1996 • 328 citations

The influence of treatment time on outcome for squamous cell cancer of the uterine cervix treated with radiation: A patterns-of-care study

1993 • 319 citations

Tumor Resistance to Alkylating Agents Conferred by Mechanisms Operative Only in Vivo

1990 • 313 citations

The influence of the number of fractions and of overall treatment time on local control and late complication rate in squamous cell carcinoma of the larynx

1983 • 289 citations

Acquired multicellular-mediated resistance to alkylating agents in cancer.

1993 • 280 citations

Defective Acidification in Human Breast Tumor Cells and Implications for Chemotherapy

1998 • 265 citations

Resistance to adriamycin in multicellular spheroids

1979 • 227 citations

Quantitative measurement of intraorganelle pH in the endosomal-lysosomal pathway in neurons by using ratiometric imaging with pyranine.

1995 • 215 citations

Randomized clinical trial on 7-day-continuous accelerated irradiation (CAIR) of head and neck cancer – report on 3-year tumour control and normal tissue toxicity

2000 • 162 citations

Randomised multicentre trials of CHART vs conventional radiotherapy in head and neck and non-small-cell lung cancer: an interim report. CHART Steering Committee

1996 • 157 citations

Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy.

1980 • 155 citations

A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma. A southwest oncology group study

1995 • 155 citations

Clinical evidence for tumor clonogen regeneration: interpretations of the data

1991 • 154 citations

Importance of overall treatment time for the outcome of radiotherapy of advanced head and neck carcinoma: dependency on tumor differentiation

1997 • 149 citations

Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion

1986 • 144 citations

TUMOUR CELL PROLIFERATION IN RELATION TO THE VASCULATURE

1979 • 143 citations

Conventional cancer therapy: promise broken or promise delayed?

1998 • 142 citations

Tumor Cell Proliferation Kinetics and Tumor Growth Rate

1989 • 137 citations

Acidification of endocytic compartments and the intracellular pathways of ligands and receptors

1984 • 136 citations

Penetration of anticancer drugs through solid tissue: a factor that limits the effectiveness of chemotherapy for solid tumors.

1999 • 134 citations

Cell selection from a murine tumour using the fluorescent probe Hoechst 33342

1985 • 120 citations

Use of Hoechst 33342 for cell selection from multicell systems.

1982 • 120 citations

Relationship between cytoplasmic pH and proliferation during exponential growth and cellular quiescence

1987 • 102 citations

Quinidine as a resistance modulator of epirubicin in advanced breast cancer: mature results of a placebo-controlled randomized trial.

1994 • 101 citations

Expansion of the growth fraction in multiple myeloma with alkylating agents

1975 • 96 citations

Aspects of cytotoxic drug penetration, with particular reference to anthracyclines

1987 • 91 citations

Invited review Multicell spheroids as a model for cell kinetic studies

1990 • 90 citations

An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours

1997 • 89 citations

Multicellular membranes as an in vitro model for extravascular diffusion in tumours.

1996 • 86 citations

Distribution and Activity of Antineoplastic Drugs in a Tumor Model

1989 • 86 citations

Chemosensitivity Testing in V79 Spheroids: Drug Delivery and Cellular Microenvironment<xref ref-type="fn" rid="FN1">2</xref>

1986 • 78 citations

Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours

1998 • 78 citations

Penetration and binding of vinblastine and 5-fluorouracil in cellular spheroids

1984 • 78 citations

Slow penetration of anthracyclines into spheroids and tumors: a therapeutic advantage?

1990 • 78 citations

Cellular proliferation patterns in an experimental Rhabdomyosarcoma in the rat

1967 • 74 citations

Randomised multicentre trials of CHART vs conventional radiotherapy in head and neck and non-small cell lung cancer : an interim report

1997 • 71 citations

Management of breast cancer patients failing adjuvant chemotherapy with adriamycin-containing regimens

1981 • 67 citations

Radiotherapy in Burkitt's lymphoma conventional or superfractionated regime—early results

1977 • 67 citations

Tumour cell repopulation during fractionated radiotherapy: Correlation between flow cytometric and radiobiological data in three murine tumours

1991 • 66 citations

A randomised clinical study of verapamil in addition to combination chemotherapy in small cell lung cancer

1993 • 66 citations

Tumour volume response, initial cell kill and cellular repopulation in B16 melanoma treated with cyclophosphamide and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea

1977 • 65 citations

Multicellular Resistance: A New Paradigm to Explain Aspects of Acquired Drug Resistance of Solid Tumors

1994 • 64 citations

Salvage treatment of patients suffering relapse after adjuvant CMF chemotherapy

1986 • 64 citations

Rapid tumor cell proliferation after induction chemotherapy in oropharyngeal cancer

1994 • 59 citations

Doxorubicin distribution in multicellular prostate cancer spheroids evaluated by confocal laser scanning microscopy and the ?optical probe technique?

1998 • 57 citations

Repair of Sublethal Radiation Injury in Hypoxic Cells of a C 3 H Mouse Mammary Carcinoma

1969 • 53 citations

Factors that influence the penetration of methotrexate through solid tissue

2000 • 53 citations

Intermittent blood flow in the KHT sarcoma--flow cytometry studies using Hoechst 33342

1990 • 53 citations

In vivo clonogenic tumor cell kinetics following 1,3-bis(2-chloroethyl)-1-nitrosourea brain tumor therapy.

1976 • 52 citations

Multilayers of Cells Growing on a Permeable Support:An in Vitro Tumour Model

1997 • 50 citations

Dynamics of tumor cell clonogen repopulation in a murine sarcoma treated with cyclophosphamide

1994 • 48 citations

The influence of expression of P-glycoprotein on the penetration of anticancer drugs through multicellular layers

2000 • 45 citations

The Na+:H+ antiport in cancer.

1986 • 40 citations

In vitro fusion of endocytic vesicles: Effects of reagents that alter endosomal pH

1996 • 39 citations

Improved treatment of a brain-tumor model

1983 • 33 citations

Changes in TCD50 as a measure of clonogen doubling time in irradiated and unirradiated tumors

1991 • 32 citations

A decade of breast cancer clinical investigation: results as reported in the Program/Proceedings of the American Society of Clinical Oncology.

1994 • 32 citations

Keynote address: Integration of cytostatic agents and radiation therapy: A different approach to “proliferating” human tumors

1991 • 25 citations

Influence of cell concentration in limiting the therapeutic benefit of P-glycoprotein reversal agents

1999 • 22 citations

The accelerated repopulation of a murine fibrosarcoma, FSa-ii, during the fractionated irradiation and the linear-quadratic model

1991 • 22 citations

Tumor Resistance to Therapy: A Genetic or Kinetic Problem?

1989 • 22 citations

The role of tissue inhibitor of metalloproteinase-1 in specific aspects of cancer progression and reproduction

1994 • 21 citations

Adding a Reverser (verapamil) to combined chemotherapy overrides resistance in small cell lung cancer xenografts

1995 • 19 citations

Reproducibility of measurements of potential doubling time of tumour cells in the multicentre National Cancer Institute protocol T92-0045

1998 • 17 citations

Retreating recurrent breast cancer with the same CMF-containing regimen used as adjuvant therapy

1997 • 16 citations

FROM BEDSIDE TO BENCH AND BACK

1992 • 15 citations

Schedule Dependence for Cisplatin and Etoposide Multifraction Treatments of Spheroids

1990 • 14 citations

The chemosensitizer cyclosporin A enhances the toxic side-effects of doxorubicin in the rat

1994 • 13 citations

Tumor cell recruitment in the mouse adenocarcinoma EO 771 directly demonstrated by double labeling with [3H]- and [14C] thymidine and flow cytometry

1989 • 11 citations