Quinidine as a resistance modulator of epirubicin in advanced breast cancer: mature results of a placebo-controlled randomized trial.

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

The Anthracycline Antineoplastic Drugs

1981 • 794 citations

Assessment of response to therapy in advanced breast cancer

1977 • 705 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for Neuroblastoma

1991 • 447 citations

P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil.

1991 • 388 citations

Modulation of multidrug-resistant multiple myeloma by cyclosporin

1992 • 317 citations

Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance.

1992 • 298 citations

Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.

1984 • 231 citations

Clinical Relevance of Immunohistochemical Detection of Multidrug Resistance P-Glycoprotein in Breast Carcinoma

1991 • 208 citations

Phase I trial of doxorubicin with cyclosporine as a modulator of multidrug resistance.

1994 • 186 citations

Clinical Correlates of MDR1 (P-glycoprotein) Gene Expression in Ovarian and Small-Cell Lung Carcinomas

1992 • 183 citations

The effect of verapamil on the pharmacokinetics of adriamycin

1986 • 146 citations

Epirubicin at two dose levels with prednisolone as treatment for advanced breast cancer: the results of a randomized trial.

1991 • 118 citations

P-glycoprotein expression in primary breast cancer detected by immunocytochemistry with two monoclonal antibodies

1990 • 85 citations

A pilot study of quinidine and epirubicin in the treatment of advanced breast cancer

1990 • 66 citations

Improved cellular accumulation is characteristic of anthracyclines which retain high activity in multidrug resistant cell lines, alone or in combination with verapamil or cyclosporin A

1989 • 62 citations

Adequate tumour quinidine levels for multidrug resistance modulation can be achieved in vivo

1992 • 29 citations