Influence of cell concentration in limiting the therapeutic benefit of P-glycoprotein reversal agents

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex.

1993 • 508 citations

Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance.

1992 • 298 citations

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia.

1993 • 284 citations

Drug and radiation resistance in spheroids: cell contact and kinetics

1994 • 268 citations

Overlapping phenotypes of multidrug resistance among panels of human cancer-cell lines

1996 • 214 citations

A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma. A southwest oncology group study

1995 • 155 citations

99Tcm-sestamibi as an agent for imaging P-glycoprotein-mediated multi-drug resistance

1995 • 114 citations

Feasibility of using quinine, a potential multidrug resistance-reversing agent, in combination with mitoxantrone and cytarabine for the treatment of acute leukemia.

1992 • 108 citations

Quinidine as a resistance modulator of epirubicin in advanced breast cancer: mature results of a placebo-controlled randomized trial.

1994 • 101 citations

Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study

1993 • 88 citations

Distribution and Activity of Antineoplastic Drugs in a Tumor Model

1989 • 86 citations

Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells.

1987 • 72 citations

A randomised clinical study of verapamil in addition to combination chemotherapy in small cell lung cancer

1993 • 66 citations

Functional intracellular P‐glycoprotein

1998 • 65 citations

Functional intracellular P-glycoprotein

1998 • 62 citations

Decreased potency of MDR‐modulators under serum conditions determined by a functional assay

1995 • 31 citations

High-Affinity Monoclonal Antibodies against P-Glycoprotein

1995 • 23 citations

pH dependent cytotoxicity of N-dodecylimidazole: a compound that acquires detergent properties under acidic conditions

1993 • 22 citations

Adding a Reverser (verapamil) to combined chemotherapy overrides resistance in small cell lung cancer xenografts

1995 • 19 citations

The chemosensitizer cyclosporin A enhances the toxic side-effects of doxorubicin in the rat

1994 • 13 citations