Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1.

Oncogenes and signal transduction

1991 • 2,816 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis

1990 • 710 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

Purification and characterization of phosphoinositide 3-kinase from rat liver.

1990 • 640 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

The insulin receptor and the molecular mechanism of insulin action.

1988 • 426 citations

Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.

1983 • 324 citations

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.

1992 • 319 citations

Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.

1992 • 317 citations

A Phosphatidylinositol-3 Kinase Binds to Platelet-Derived Growth Factor Receptors through a Specific Receptor Sequence Containing Phosphotyrosine

1991 • 294 citations

Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase.

1990 • 266 citations

Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.

1990 • 244 citations

Monoclonal antibodies to phosphotyrosine

1988 • 242 citations

Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions.

1992 • 241 citations

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.

1992 • 228 citations

Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling.

1992 • 212 citations

Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase

1991 • 198 citations

Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.

1987 • 195 citations

SH2 Domains of the p85α Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors

1992 • 186 citations

YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase.

1992 • 170 citations

Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form

1991 • 151 citations

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor.

1992 • 143 citations

Characterization of an endogenous substrate of the insulin receptor in cultured cells.

1987 • 136 citations

Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase.

1992 • 133 citations

Purification and characterization of bovine brain type I phosphatidylinositol kinase

1990 • 129 citations

Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells.

1987 • 125 citations

Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

1982 • 122 citations

A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine.

1991 • 119 citations

Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction.

1991 • 109 citations

Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro.

1992 • 79 citations

SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors.

1992 • 74 citations

Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors

1991 • 69 citations

Substrates for Insulin-Receptor Kinase

1990 • 63 citations

Insulin Receptor Structure and Function in Normal and Pathological Conditions

1990 • 48 citations

In vitro association of phosphatidylinositol 3-kinase activity with the activated insulin receptor tyrosine kinase.

1992 • 43 citations

Tyrosine Phosphorylation of pp185 by Insulin Receptor Kinase in a Cell-free System

1989 • 24 citations

PLATE BINDING ASSAY FOR MONOCLONAL ANTI–RECEPTOR ANTIBODIES

1985 • 23 citations

Synthesis of phosphotyrosyl-containing phosphopeptides by solid-phase peptide synthesis

1990 • 14 citations

Synthesis of a tri-phosphorylated peptide corresponding to the major autophosphorylation site in the insulin receptor: conformational comparison with its non-phosphorylated analogue

1991 • 5 citations