Heat shock and the heat shock proteins

The induction of gene activity in drosophila by heat shock

1979 • 1,308 citations

Heat shock, from bacteria to man

1982 • 1,260 citations

Protein synthesis in salivary glands of Drosophila melanogaster: Relation to chromosome puffs

1974 • 1,189 citations

A regulatory upstream promoter element in the Drosophila Hsp 70 heat-shock gene

1982 • 1,038 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

The Heat Shock Respons

1985 • 809 citations

Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts.

1982 • 754 citations

THE GENETICS AND REGULATION OF HEAT-SHOCK PROTEINS

1984 • 648 citations

Mechanisms of Intracellular Protein Breakdown

1982 • 647 citations

The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts

1978 • 547 citations

The heat shock response is self-regulated at both the transcriptional and posttranscriptional levels

1982 • 542 citations

A drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene

1984 • 534 citations

Hyperthermic Oncology 1984

1985 • 528 citations

The common 90-kd protein component of non-transformed ‘8S’ steroid receptors is a heat-shock protein.

1985 • 527 citations

Nuclear and nucleolar localization of the 72,000-dalton heat shock protein in heat-shocked mammalian cells.

1984 • 522 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous.

1984 • 513 citations

Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein.

1985 • 492 citations

Hyperthermia and Cancer

1982 • 474 citations

Hsp70 accelerates the recovery of nucleolar morphology after heat shock.

1984 • 456 citations

Regulation of protein synthesis during heat shock

1981 • 451 citations

Synthesis and degradation of heat shock proteins during development and decay of thermotolerance.

1982 • 433 citations

Biochemical characterization of the mammalian stress proteins and identification of two stress proteins as glucose- and Ca2+-ionophore-regulated proteins.

1983 • 431 citations

Heat shock proteins, first major products of zygotic gene activity in mouse embryo

1983 • 401 citations

hsp70: Nuclear concentration during environmental stress and cytoplasmic storage during recovery

1984 • 400 citations

Ubiquitin is a heat shock protein in chicken embryo fibroblasts.

1985 • 392 citations

Consensus sequence for Escherichia coli heat shock gene promoters.

1985 • 372 citations

Purification of the major mammalian heat shock proteins.

1982 • 369 citations

Rapid purification of mammalian 70,000-dalton stress proteins: affinity of the proteins for nucleotides.

1985 • 365 citations

Accumulation of a specific subset of D. melanogaster heat shock mRNAs in normal development without heat shock

1983 • 365 citations

Translational control of protein synthesis in response to heat shock in D. melanogaster cells

1980 • 356 citations

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1986 • 354 citations

Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eukaryotic cells

1980 • 343 citations

Localization of RNA from heat-induced polysomes at puff sites in Drosophila melanogaster.

1975 • 332 citations

Common Control of the Heat Shock Gene and Early Adenovirus Genes: Evidence for a Cellular E1A-like Activity

1984 • 331 citations

Activating protein factor binds in vitro to upstream control sequences in heat shock gene chromatin

1984 • 329 citations

The Molecular Biology of the Yeast Saccharomyces

1983 • 329 citations

The dnaK protein modulates the heat-shock response of Escherichia coli

1983 • 328 citations

Involvement of ATP in the nuclear and nucleolar functions of the 70 kd heat shock protein.

1985 • 327 citations

Human HSP70 promoter contains at least two distinct regulatory domains.

1986 • 326 citations

Genetic control of heat-shock protein synthesis and its bearing on growth and thermal resistance in Escherichia coli K-12.

1982 • 322 citations

Induction of thermotolerance and enhanced heat shock protein synthesis in chinese hamster fibroblasts by sodium arsenite and by ethanol

1983 • 306 citations

A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.

1985 • 304 citations

The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles.

1985 • 301 citations

Ubiquitin: Roles in protein modification and breakdown

1983 • 297 citations

Transcriptional activation and subsequent control of the human heat shock gene during adenovirus infection.

1983 • 295 citations

An Ancient Developmental Induction: Heat-Shock Proteins Induced in Sporulation and Oogenesis

1986 • 294 citations

Messenger RNA in heat-shocked Drosophila cells

1977 • 292 citations

The preferential translation of Drosophila hsp70 mRNA requires sequences in the untranslated leader

1985 • 291 citations

Heat shock-induced translational alterations in HeLa cells. Initiation factor modifications and the inhibition of translation.

1984 • 282 citations

The structure and expression of maize genes encoding the major heat shock protein, hsp70

1986 • 281 citations

Mutations of the heat inducible 70 kilodalton genes of yeast confer temperature sensitive growth

1984 • 278 citations

Regulation of heat shock protein 70 gene expression by c-myc

1984 • 270 citations

Positive regulatory gene for temperature-controlled proteins in Escherichia coli

1981 • 268 citations

The dnaK protein of Escherichia coli possesses an ATPase and autophosphorylating activity and is essential in an in vitro DNA replication system.

1983 • 260 citations

Nuclear location of the putative transforming protein of avian myelocytomatosis virus

1982 • 245 citations

Transcription of the human hsp70 gene is induced by serum stimulation.

1985 • 235 citations

Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation.

1984 • 229 citations

Integration, transcription, and control of a Drosophila heat shock gene in mouse cells.

1981 • 212 citations

Coordinate regulation of the synthesis of eukaryotic ribosomal proteins.

1976 • 206 citations

Ethanol-induced tolerance to heat and to adriamycin

1978 • 201 citations

Drosophila gene related to the major heat shock-induced gene is transcribed at normal temperatures and not induced by heat shock.

1982 • 196 citations

Developmental control of the heat shock response in Xenopus.

1984 • 195 citations

Spatial and temporal pattern of hsp26 expression during normal development.

1986 • 193 citations

Complete sequence of the heat shock-inducible HSP90 gene of Saccharomyces cerevisiae.

1984 • 189 citations

Spontaneous high expression of heat-shock proteins in mouse embryonal carcinoma cells and ectoderm from day 8 mouse embryo.

1983 • 187 citations

The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related

1983 • 178 citations

Saccharomyces cerevisiae contains a complex multigene family related to the major heat shock-inducible gene of Drosophila.

1982 • 177 citations

Altered expression of heat shock proteins in embryonal carcinoma and mouse early embryonic cells.

1984 • 173 citations

Heat shock proteins are methylated in avian and mammalian cells.

1981 • 173 citations

Molecular genetics: What turns on heat shock genes?

1985 • 171 citations

Intracellular localization of heat shock proteins in Drosophila

1980 • 169 citations

Localization of the heat shock-induced proteins in Drosophila melanogaster tissue culture cells

1980 • 169 citations

Translational control in lysates of Drosophila melanogaster cells.

1981 • 167 citations

Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment.

1985 • 164 citations

A HEAT-SENSITIVE CELLULAR FUNCTION LOCATED IN THE NUCLEOLUS

1967 • 161 citations

Selective translation of heat shock mRNA in Drosophila melanogaster depends on sequence information in the leader.

1985 • 160 citations

Xenopus hsp 70 genes are constitutively expressed in injected oocytes.

1984 • 159 citations

Heat-resistant variants of Chinese hamster fibroblasts altered in expression of heat shock protein.

1985 • 151 citations

Simian virus 40 and polyoma virus induce synthesis of heat shock proteins in permissive cells.

1983 • 148 citations

Mutations in cognate genes of Saccharomyces cerevisiae hsp70 result in reduced growth rates at low temperatures.

1985 • 147 citations

Purification and properties of the Escherichia coli dnaK replication protein.

1984 • 144 citations

Separate regulatory elements for the heat-inducible and ovarian expression of the drosophila hsp26 gene

1985 • 138 citations

Chromatin-associated heat shock proteins of Dictyostelium

1982 • 133 citations

Transcriptional Activation and Subsequent Control of the Human Heat Shock Gene During Adenovirus Infection

1983 • 131 citations

Association between the mammalian 110,000-dalton heat-shock protein and nucleoli.

1983 • 121 citations

In vitro translation of drosophila heat-shock and non-heat-shock mRNAs in heterologous and homologous cell-free systems

1981 • 117 citations

Hyperthermia in cancer therapy: the biological basis and unresolved questions.

1985 • 116 citations

Actin gene mutations in Drosophila ; heat shock activation in the indirect flight muscles

1985 • 116 citations

Primary sequence of the 5′ flanking regions of the Drosophila heat shock genes in chromosome subdivision 67B

1981 • 115 citations

Specific heat shock proteins are transported into chloroplasts

1986 • 115 citations

Translational efficiency of heat-induced messages in Drosophila melanogaster cells

1980 • 112 citations

Synthesis, transport and localization of a nuclear coded 22-kd heat-shock protein in the chloroplast membranes of peas and Chlamydomonas reinhardi

1985 • 111 citations

Characterization of the prosome from Drosophila and its similarity to the cytoplasmic structures formed by the low molecular weight heat-shock proteins.

1985 • 110 citations

Synthesis of two classes of small RNA species in vivo and in vitro

1977 • 109 citations

RNA Metabolism in Mammalian Cells at Elevated Temperature

1969 • 109 citations

Nuclear Localization and Phosphorylation of Three 25-Kilodalton Rat Stress Proteins

1984 • 107 citations

Regulated transcription of the genes for actin and heat-shock proteins in culture drosophila cells

1981 • 107 citations

Heat shock and Phenocopy induction in Drosophila

1978 • 107 citations

Localization of the hsp83 transcript within a 3292 nucleotide sequence from the 63B heat shock locus ofD. melanogaster

1983 • 106 citations

Ubiquitin Is a Heat Shock Protein in Chicken Embryo Fibroblasts

1985 • 105 citations

Rapid Purification of Mammalian 70,000-Dalton Stress Proteins: Affinity of the Proteins for Nucleotides

1985 • 104 citations

ADP-ribosylation of the Mr 83,000 stress-inducible and glucose-regulated protein in avian and mammalian cells: modulation by heat shock and glucose starvation.

1983 • 104 citations

The effects of glucose on protein synthesis and thermosensitivity in Chinese hamster ovary cells.

1983 • 103 citations

A nonsense mutation within the act88f actin gene disrupts myofibril formation in Drosophila indirect flight muscles

1984 • 103 citations

Herpes simplex virus infection causes the accumulation of a heat-shock protein.

1984 • 102 citations

Transcription of a Drosophila heat shock gene is heat-induced in Xenopus oocytes.

1982 • 102 citations

Mechanism of inhibition of polypeptide chain initiation in heat-shocked Ehrlich cells involves reduction of eukaryotic initiation factor 4F activity.

1985 • 101 citations

The behavior of HeLa-S3 cells under the influence of supranormal temperatures

1971 • 95 citations

The Pattern of Protein Synthesis Induced by Heat Shock of HeLa Cells

1981 • 89 citations

Activation of hemin-regulated initiation factor-2 kinase in heat-shocked HeLa cells.

1986 • 84 citations

Heat-shock proteins are associated with hnRNA in Drosophila melanogaster tissue culture cells

1983 • 83 citations

Inducible expression of a cloned heat shock fusion gene in sea urchin embryos.

1984 • 81 citations

Mild temperature shock alters the transcription of a discrete class of Saccharomyces cerevisiae genes.

1983 • 81 citations

Embryonic stress hypothesis of teratogenesis

1984 • 79 citations

Similarities in Cellular Inactivation by Hyperthermia or by Ethanol

1980 • 77 citations

The 68,000-dalton neurofilament-associated polypeptide is a component of nonneuronal cells and of skeletal myofibrils

1980 • 77 citations

Cell-specific expression of heat shock proteins in chicken reticulocytes and lymphocytes.

1984 • 76 citations

Proteins related to the mouse L-cell major heat shock protein are synthesized in the absence of heat shock gene expression.

1984 • 75 citations

Cloning and analysis of cDNA sequences coding for two 16 kllodalton heat shock proteins (hsps) inCaenorhabditis elegans:homology with the small hsps ofDrosophila

1983 • 72 citations

The relationship of the rat brain 68 kDa microtubule-associated protein with synaptosomal plasma membranes and with the Drosophila 70 kDa heat-shock protein

1984 • 71 citations

Immunofluorescence localization of a small heat shock protein (hsp 23) in salivary gland cells of Drosophila melanogaster

1981 • 69 citations

Activation of cellular promoters during herpes virus infection of biochemically transformed cells.

1985 • 69 citations

Steroid and high-temperature induction of the small heat-shock protein genes in Drosophila

1984 • 68 citations

Self-degradation of heat shock proteins.

1985 • 68 citations

Induction of heat shock protein synthesis in murine tumors during the development of thermotolerance.

1985 • 63 citations

Inhibition of the heat shock response and synthesis of glucose-regulated proteins in Ca 2+ -deprived rat hepatoma cells

1985 • 62 citations

RNA metabolism during puff induction in Drosophila melanogaster

1971 • 61 citations

The origin of the very variable haemolytic activities of the common human complement component C4 allotypes including C4-A6.

1985 • 60 citations

Effet de la température supra-optimale sur les ribonucléoprotéines et le RNA nucléolaire

1969 • 58 citations

Hyperthermia and the heat-shock proteins of HeLa cells

1982 • 57 citations

Alterations of transcription and translation in HeLa cells exposed to amino acid analogs.

1984 • 56 citations

Saccharomyces cerevisiae Contains a Complex Multigene Family Related to the Major Heat Shock-Inducible Gene of Drosophila

1982 • 56 citations

Heat shock induced changes of plant cell ultrastructure and autoradiographic localization of heat shock proteins.

1984 • 55 citations

Heat shock causes diverse changes in the phosphorylation of the ribosomal proteins of mammalian cells

1984 • 54 citations

Coprecipitation of heat shock proteins with a cell surface glycoprotein.

1982 • 52 citations

Heat shock protein synthesis and cell survival in clones of normal and simian virus 40-transformed mouse embryo cells.

1984 • 51 citations

The Effects of Alcohols, Procaine and Hyperthermia on the Protein Content of Nuclei and Chromatin

1984 • 50 citations

A major heat-shock protein defined by a monoclonal antibody.

1984 • 49 citations

Altered Expression of Heat Shock Proteins in Embryonal Carcinoma and Mouse Early Embryonic Cells

1984 • 48 citations

Metabolite regulation of heat shock protein levels.

1983 • 45 citations

Dephosphorylation of S6 and expression of the heat shock response in Drosophila melanogaster.

1983 • 43 citations

Transient paralysis by heat shock of hormonal regulation of gene expression.

1984 • 43 citations

Thermal tolerance and specific protein synthesis in Chinese hamster fibroblasts exposed to prolonged hypoxia

1982 • 43 citations

A repetitive Dictyostelium gene family that is induced during differentiation and by heat shock

1983 • 43 citations

Mutations in Cognate Genes of Saccharomyces cerevisiae hsp70 Result in Reduced Growth Rates at Low Temperatures

1985 • 41 citations

Simian Virus 40 and Polyoma Virus Induce Synthesis of Heat Shock Proteins in Permissive Cells

1983 • 41 citations

Thermo-induced transcripts of a soybean heat shock gene after transfer into sunflower using a Ti plasmid vector

1985 • 38 citations

Nucleotide sequences responsible for the thermal inducibility of the Drosophila small heat-shock protein genes in monkey COS cells

1985 • 38 citations

Heat shock increases the synthesis of the poly(A)-binding protein in HeLa cells.

1985 • 34 citations

Hyperthermia, Na+K+ATPase and lactic acid production in some human tumour cells

1984 • 32 citations

Mild Temperature Shock Alters the Transcription of a Discrete Class of Saccharomyces cerevisiae Genes

1983 • 32 citations

Regulation of protein synthesis in heat-shocked Drosophila cells. Soluble factors control translation in vitro.

1986 • 28 citations

Localization of the 70000 Dalton Heat-induced protein in the nuclear matrix of BHK cells

1983 • 23 citations

Polypeptides encoded by polyadenylated and non-polyadenylated messenger RNAs from normal and heat shocked HeLa cells

1981 • 21 citations

Alterations of Transcription and Translation in HeLa Cells Exposed to Amino Acid Analogs

1984 • 18 citations

A heat-sensitive cellular function required for the replication of DNA viruses but not RNA viruses

1965 • 18 citations

Unusual processing of nucleolar RNA synthesized during a heat shock in CHO cells

1981 • 16 citations

Heterogeneity in induced heat resistance and its relation to synthesis of stress proteins in rat tumor cell clones.

1984 • 16 citations

Inhibition of stable RNA synthesis and production of a novel RNA in heat-stressed plants

1981 • 13 citations

Dephosphorylation of S6 and Expression of the Heat Shock Response in Drosophila melanogaster

1983 • 10 citations

Delay In Entry Into S Phase After Heat Shock

1984 • 8 citations

Inhibition of DMSO-induced differentiation by hyperthermia in a murine erythroleukemia cell system

1984 • 7 citations

Expression of the major heat shock gene ofDrosophilla melanogasterinSaccharomyces cerevisiae

1986 • 6 citations