Tumors and inflammatory infiltrates: friends or foes?

Inflammation and cancer

2002 • 14,174 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

1997 • 4,867 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

1994 • 2,251 citations

Ulcerative Colitis and Colorectal Cancer

1990 • 1,755 citations

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1998 • 1,535 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

1997 • 1,235 citations

Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation

1998 • 1,190 citations

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

1999 • 1,091 citations

The origin and function of tumor-associated macrophages

1992 • 1,081 citations

Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

1999 • 833 citations

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

1999 • 830 citations

Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression

2000 • 815 citations

Transforming growth factor-beta: recent progress and new challenges.

1992 • 781 citations

Distinct patterns and kinetics of chemokine production regulate dendritic cell function

1999 • 692 citations

Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice

1992 • 650 citations

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1998 • 612 citations

Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells

2000 • 592 citations

The CXC Chemokine Receptor 2, CXCR2, Is the Putative Receptor for ELR+ CXC Chemokine-Induced Angiogenic Activity

2000 • 565 citations

The biology of the 17–1A antigen (Ep-CAM)

1999 • 541 citations

An overview of the MAGE gene family with the identification of all human members of the family.

2001 • 477 citations

Effects of Thalidomide and Related Metabolites in a Mouse Corneal Model of Neovascularization

1997 • 447 citations

Ulcerative colitis and colorectal cancer

1991 • 421 citations

Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.

1998 • 419 citations

The intriguing role of polymorphonuclear neutrophils in antitumor reactions

2001 • 411 citations

TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages.

1996 • 409 citations

Clinicopathological study on hepatocellular carcinoma with lymphocytic infiltration

1998 • 377 citations

Cell cycle–dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity

2001 • 377 citations

Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma.

1994 • 373 citations

Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes.

1995 • 372 citations

Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.

1997 • 369 citations

Regulation of the Macrophage Content of Neoplasms by Chemoattractants

1983 • 352 citations

Continuous low dose Thalidomide: a phase II study in advanced melanoma, renal cell, ovarian and breast cancer

2000 • 346 citations

‘Angioprevention’: angiogenesis is a common and key target for cancer chemopreventive agents

2002 • 330 citations

Expression of cyclooxygenase-2 in prostate carcinoma

2000 • 319 citations

Potent inhibitory action of red wine polyphenols on human breast cancer cells

2000 • 318 citations

Elevated cyclooxygenase-2 levels in Min mouse adenomas

1996 • 311 citations

Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils.

1999 • 308 citations

Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells.

1992 • 303 citations

Clinical trials of antibody therapy

2000 • 297 citations

The CXC Chemokines IP-10 and Mig Are Necessary for IL-12-Mediated Regression of the Mouse RENCA Tumor

1998 • 295 citations

Expression and regulation of chemokine receptors in human natural killer cells

2001 • 293 citations

Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis

2000 • 271 citations

Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies

1993 • 254 citations

Role of Interleukin-8 in Tumor Growth and Metastasis of Human Melanoma

1999 • 248 citations

Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses

1998 • 245 citations

Low-Level Monocyte Chemoattractant Protein-1 Stimulation of Monocytes Leads to Tumor Formation in Nontumorigenic Melanoma Cells

2001 • 227 citations

Differential antiproliferative and apoptotic response of sanguinarine for cancer cells versus normal cells.

2000 • 225 citations

Chemokines induce migrational responses in human breast carcinoma cell lines

1997 • 222 citations

Combined chemokine and cytokine gene transfer enhances antitumor immunity

1996 • 215 citations

Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression

1997 • 208 citations

Tumor-associated macrophages in neoplastic progression: a paradigm for the in vivo function of chemokines.

1994 • 205 citations

Extracellular ATP and TNF-α Synergize in the Activation and Maturation of Human Dendritic Cells

2000 • 197 citations

Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8.

1993 • 196 citations

Delayed Wound Healing in Immunodeficient TGF-β1 Knockout Mice

2000 • 193 citations

Neutrophils as a key cellular target for angiostatin: implications for regulation of angiogenesis and inflammation

2001 • 184 citations

Herceptin<sup>®</sup> Alone or in Combination with Chemotherapy in the Treatment of HER2-Positive Metastatic Breast Cancer: Pivotal Trials

2001 • 179 citations

Endothelial Cells Differentially Express Functional CXC-Chemokine Receptor-4 (CXCR-4/Fusin) under the Control of Autocrine Activity and Exogenous Cytokines

1998 • 172 citations

Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway

2000 • 172 citations

Cytokines, tumour-cell death and immunogenicity: a question of choice

1997 • 168 citations

PML nuclear bodies are general targets for inflammation and cell proliferation.

1995 • 163 citations

Invasion and metastasis of a mammary tumor involves TGF-? signaling

2000 • 148 citations

Induction of apoptosis by hydrolyzable tannins from Eugenia jambos L. on human leukemia cells

2000 • 141 citations

PAF Produced by Human Breast Cancer Cells Promotes Migration and Proliferation of Tumor Cells and Neo-Angiogenesis

2000 • 135 citations

Induction of Functional IL-8 Receptors by IL-4 and IL-13 in Human Monocytes

2000 • 132 citations

Malignant tumor and eosinophils: I. Prognostic significance in gastric cancer

1986 • 128 citations

Quantitative analysis of chemokine expression by dendritic cell subsets in vitro and in vivo

2001 • 123 citations

Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus.

1994 • 117 citations

Human neutrophils exhibit disparate chemotactic factor gene expression

1990 • 114 citations

Review Article The immunology and immunotherapy of breast cancer: an update

1999 • 111 citations

Expression of adhesion molecules, platelet-activating factor, and chemokines by Kaposi's sarcoma cells.

1994 • 104 citations

Piceatannol, a Stilbene Phytochemical, Inhibits Mitochondrial F0F1-ATPase Activity by Targeting the F1 Complex

1999 • 100 citations

Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers.

1995 • 99 citations

Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway.

2001 • 97 citations

A phase II study of the bispecific antibody MDX-H210 (anti-HER2 × CD64) with GM-CSF in HER2+ advanced prostate cancer

2001 • 97 citations

Fas/Fas Ligand Interaction in Human Colorectal Hepatic Metastases

1999 • 96 citations

Peripheral burst of tumor-specific cytotoxic T lymphocytes and infiltration of metastatic lesions by memory CD8+ T cells in melanoma patients receiving interleukin 12.

2000 • 95 citations

Prostaglandin E2 Suppressed IL-15-Mediated Human NK Cell Function Through Down-Regulation of Common γ-Chain

2001 • 91 citations

Cytokine Expression and Release by Neutrophils^a

1997 • 90 citations

IL-2 up-regulates but IFN-gamma suppresses IL-8 expression in human monocytes.

1993 • 88 citations

IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells.

2001 • 85 citations

Interleukin 1 alpha acts as an autocrine growth stimulator for human gastric carcinoma cells.

1993 • 85 citations

Anti‐tumor and immunomodulatory activity of intraperitoneal IFN‐γ in ovarian carcinoma patients with minimal residual tumor after chemotherapy

1992 • 79 citations

The Combined Action of IL-15 and IL-12 Gene Transfer Can Induce Tumor Cell Rejection Without T and NK Cell Involvement

2000 • 76 citations

Human Small Cell Lung Carcinoma and Carcinoid Tumor Regulate Dendritic Cell Maturation and Function

2001 • 72 citations

A candidate for cancer gene therapy: MIP-1 alpha gene transfer to an adenocarcinoma cell line reduced tumorigenicity and induced protective immunity in immunocompetent mice.

1996 • 70 citations

Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway.

1998 • 70 citations

Anticachectic effects of Coptidis rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce interleukin 6

2000 • 69 citations

Human Immunodeficiency Virus Transactivator Protein (Tat) Stimulates Chemotaxis, Calcium Mobilization, and Activation of Human Polymorphonuclear Leukocytes: Implications for Tat‐Mediated Pathogenesis

2000 • 67 citations

Role of tumor necrosis factor-alpha inhibition with inflixiMAB in cancer therapy and hematopoietic stem cell transplantation

2000 • 67 citations

Ajoene, a natural product with non-steroidal anti-inflammatory drug (NSAID)-like properties?

2001 • 65 citations

Threshold levels of gene expression of the melanoma antigen gp100 correlate with tumor cell recognition by cytotoxic T lymphocytes

2000 • 64 citations

Eosinophils infiltrating interleukin‐5 gene‐transfected tumors do not suppress tumor growth

1993 • 50 citations

Reduction of oxidative stress and cytokine-induced neutrophil chemoattractant (CINC) expression by red wine polyphenols in zinc deficiency induced intestinal damage of rat

2000 • 44 citations

Significance of tumor associated tissue eosinophilia and other inflammatory cell infiltrate in early esophageal squamous cell carcinoma.

2000 • 44 citations

A new method of antitumor therapy with a high dose of TNF perfusion for unresectable liver tumors.

2000 • 42 citations

Platelet-Activating Factor Synthesized by IL-12-Stimulated Polymorphonuclear Neutrophils and NK Cells Mediates Chemotaxis

1998 • 41 citations

Activation of B lymphocytes by NK cells

1992 • 40 citations

Evidence for IL-12-Activated Ca2+ and Tyrosine Signaling Pathways in Human Neutrophils

1998 • 40 citations

Antitumor and antimetastatic effects of interleukin 12

1996 • 29 citations

A synthetic peptide inhibitor for α-chemokines inhibits the tumour growth and pulmonary metastasis of human melanoma cells in nude mice

1999 • 27 citations

On the role of hydroxyl radical and the effect of tetrandrine on nuclear factor--kappaB activation by phorbol 12-myristate 13-acetate.

2000 • 27 citations

Antitumor effects of the combination therapy with TNF-α gene–modified tumor cells and interleukin 12 in a melanoma model in mice

2000 • 26 citations

Serum-Soluble IL-2 Receptor and IL-6 Levels in Patients with Melanoma

1997 • 23 citations

TGF-?-based immunotherapy for cancer: Breaching the tumor firewall

2000 • 22 citations

Esculentoside A Inhibits Tumor Necrosis Factor, Interleukin-1, and Interleukin-6 Production Induced by Lipopolysaccharide in Mice

1998 • 20 citations

The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.

2001 • 19 citations

Limited Proteolysis of Angiogenin by Elastase Is Regulated by Plasminogen

1997 • 18 citations

Tumor cells cotransduced with B7.1 and γ-IFN induce effective rejection of established parental tumor

1999 • 16 citations

The antiangiogenic agent linomide inhibits tumor necrosis factor-α secretion via inhibition of its synthesis

1996 • 16 citations

Tumor-specific cytokine release by donor T cells induces an effective host anti-tumor response through recruitment of host naive antigen presenting cells

1999 • 15 citations

Biological Implications of Growth Factors on the Mechanism of Invasion in Gynecological Tumor Cells

1999 • 11 citations

Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors.

1986 • 11 citations

Anti-T antibodies and peanut-agglutinin-binding glycoproteins in sera of patients with gastric cancer

1999 • 6 citations

Suppression of intestinal polyposis by inhibition of COX-2 in Apc knockout mice.

1997 • 5 citations