Extracellular ATP and TNF-α Synergize in the Activation and Maturation of Human Dendritic Cells

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

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The Dendritic Cell System and its Role in Immunogenicity

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Tolerance, Danger, and the Extended Family

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Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

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Natural adjuvants: Endogenous activators of dendritic cells

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Nomenclature and classification of purinoceptors.

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Consequences of Cell Death

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The immune system evolved to discriminate infectious nonself from noninfectious self

1992 • 1,324 citations

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

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Purinoceptors: Are there families of P2X and P2Y purinoceptors?

1994 • 1,079 citations

Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood

1996 • 696 citations

CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells

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Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin

1997 • 477 citations

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1989 • 424 citations

Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor.

1993 • 350 citations

Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor.

1993 • 318 citations

Prostaglandin E2 and Tumor Necrosis Factor α Cooperate to Activate Human Dendritic Cells: Synergistic Activation of Interleukin 12 Production

1997 • 281 citations

Pharmacological characterization of the human P2Y₁₁ receptor

1999 • 270 citations

P_2Z/P2X₇receptor-dependent apoptosis of dendritic cells

1999 • 218 citations

Increased Proliferation Rate of Lymphoid Cells Transfected with the P2X7 ATP Receptor

1999 • 207 citations

Dendritic cells require maturation via CD40 to generate protective antitumor immunity.

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Extracellular ATP in T-lymphocyte activation: possible role in effector functions.

1990 • 196 citations

Increased release of ATP from endothelial cells during acute inflammation

1998 • 185 citations

Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto‐nucleotidases

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Cutting Edge: Dendritic Cells Require Maturation via CD40 to Generate Protective Antitumor Immunity

1998 • 155 citations

The injured cell: the role of the dendritic cell system as a sentinel receptor pathway

1995 • 154 citations

Mouse Dendritic Cells Express the P2X7 Purinergic Receptor: Characterization and Possible Participation in Antigen Presentation

1999 • 153 citations

ATP released by LPS increases nitric oxideproduction in raw 264.7 macrophage cell line viaP2ZP2X7 receptors

1998 • 125 citations

Establishment of a cell line with features of early dendritic cell precursors from fetal mouse skin

1995 • 109 citations

Synergistic effect of acute hypoxia on flow-induced release of ATP from cultured endothelial cells

1995 • 108 citations

Functional and Molecular Diversity of Purinergic Ion Channel Receptors

1999 • 100 citations

Mechanical stress induces release of ATP from Ehrlich ascites tumor cells

1999 • 67 citations

Extracellular Uridine Nucleotides Initiate Cytokine Production by Murine Dendritic Cells

1999 • 61 citations

Expression and a role of functionally coupled P2Y receptors in human dendritic cells

1999 • 53 citations

Purinoceptor function in the immune system

1996 • 46 citations

P2Y nucleotide receptors in the immune system: Signaling by a P2Y2 receptor in U937 monocytes

1998 • 20 citations

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