What is missing in immunology to understand immunity?

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

The Influence of Antigen Organization on B Cell Responsiveness

1993 • 701 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Immunology Taught by Viruses

1996 • 656 citations

The production of antibodies

1949 • 526 citations

ON IMMUNOLOGICAL MEMORY

1996 • 482 citations

NEUTRALIZING ANTIVIRAL B CELL RESPONSES

1997 • 467 citations

Immune surveillance against a solid tumor fails because of immunological ignorance

1999 • 463 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

POSITIVE VERSUS NEGATIVE SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1998 • 320 citations

Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

1995 • 308 citations

Thymus-Independent B-Cell Induction and Paralysis

1975 • 304 citations

The Protection: The Unit of Humoral Immunity Selected by Evolution

1990 • 236 citations

Receptor Selection in B and T Lymphocytes

2000 • 226 citations

The Origin and Mechanism of the Allograft Reaction

1977 • 217 citations

Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.

1995 • 197 citations

On the Key Role of Secondary Lymphoid Organs in Antiviral Immune Responses Studied in Alymphoplastic (aly/aly) and Spleenless (Hox11−/−) Mutant Mice

1997 • 190 citations

The monocyte in cellular immunity.

1970 • 159 citations

Experimental Studies on the Pathogenesis of Contact Eczema in the Guinea-Pig

1957 • 136 citations

Nude Mice in Immunology

2015 • 114 citations

On T Cell Memory: Arguments for Antigen Dependence

1996 • 113 citations

Positive Selection of Thymocytes

1995 • 103 citations

The pathogenesis of infectious disease

1988 • 102 citations

The pathogenesis of infectious disease

1983 • 94 citations

Role of dendritic cells in the induction and maintenance of autoimmune diseases

1999 • 88 citations

The interaction between virus and antibody

1963 • 85 citations

On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells

1999 • 83 citations

The Production of Antibodies

1950 • 78 citations

Cellular and Molecular Mechanisms of B Lymphocyte Tolerance

1992 • 61 citations

Why Positive Selection?

1993 • 52 citations

Role of Antigen Structure in the Discrimination between Tolerance and Immunity by B Cells

1975 • 51 citations

Primary antibody responses to a well-defined and unique hapten are not enhanced by preimmunization with carrier: analysis in a viral model.

1986 • 50 citations

The death and resurrection of tuberculosis

1999 • 42 citations

Antigens as Immunoregulators

1990 • 18 citations

Isolation and molecular characterization of the B cells producing the paraprotein in a case of benign monoclonal gammapathy in C57BL mice

1991 • 6 citations

Cells Inducing Tolerance to Mls and H-2 Antigens

1991 • 1 citations

Desert Hermits

1997 • 1 citations