Thymus-Independent B-Cell Induction and Paralysis

The Fluid Mosaic Model of the Structure of Cell Membranes

1972 • 8,835 citations

A rapid method for the isolation of functional thymus‐derived murine lymphocytes

1973 • 4,203 citations

Plaque Formation in Agar by Single Antibody-Producing Cells

1963 • 2,385 citations

IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICE

1967 • 2,062 citations

Laser Compression of Matter to Super-High Densities: Thermonuclear (CTR) Applications

1972 • 1,797 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Control of proliferation in animal cells

1974 • 1,177 citations

A POPULATION OF LYMPHOCYTES BEARING A MEMBRANE RECEPTOR FOR ANTIGEN-ANTIBODY-COMPLEMENT COMPLEXES

1970 • 1,144 citations

Redistribution and Pinocytosis of Lymphocyte Surface Immunoglobulin Molecules Induced by Anti-Immunoglobulin Antibody

1971 • 1,093 citations

FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES

1973 • 1,046 citations

THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION

1955 • 700 citations

Genetic Control of Specific Immune Responses

1969 • 681 citations

Cytotoxic Effects of Lymphoid Cells in Vitro

1969 • 643 citations

CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE

1968 • 639 citations

The Regulatory Influence of Activated T Cells on B Cell Responses to Antigen

1972 • 633 citations

Thymus-Marrow Cell Combinations. Synergism in Antibody Production.

1966 • 613 citations

A Requirement for Two Cell Types for Antibody Formation in vitro

1967 • 612 citations

FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES

1973 • 611 citations

Progress in immunology

1968 • 577 citations

IMMUNOGLOBULIN SPOTS ON THE SURFACE OF RABBIT LYMPHOCYTES

1970 • 553 citations

THYMUS-DEPENDENT AREAS IN THE LYMPHOID ORGANS OF NEONATALLY THYMECTOMIZED MICE

1966 • 537 citations

Replacement of T-Cell Function by a T-Cell Product

1972 • 537 citations

Two distinct populations of peripheral lymphocytes in mice distinguishable by immunofluorescence.

1970 • 479 citations

A RECEPTOR FOR ANTIBODY ON B LYMPHOCYTES

1972 • 469 citations

The dynamic state of the lymphocyte membrane. Factors affecting the distribution and turnover of surface immunoglobulins

1972 • 450 citations

Receptor Mobility and Receptor-Cytoplasmic Interactions in Lymphocytes

1973 • 449 citations

Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides

1972 • 431 citations

Croonian lecture.—On immunity with special reference to cell life

1900 • 427 citations

Lymphocyte activation. I. Response of T and B lymphocytes to phytomitogens.

1971 • 413 citations

Aeronautics before 1919

1971 • 413 citations

Selective induction of DNA synthesis in T and B lymphocytes

1972 • 411 citations

PHYLOGENY OF IMMUNOGLOBULIN STRUCTURE AND FUNCTION

1967 • 404 citations

The Mechanism of Immunological Paralysis

1968 • 401 citations

Chemical Characterization and Surface Orientation of the Major Glycoprotein of the Human Erythrocyte Membrane

1972 • 401 citations

THE CELLULAR BASIS OF IMMUNOLOGICAL RESPONSES

1969 • 396 citations

The Mitogenic Effects of Endotoxin and Staphylococcal Enterotoxin B on Mouse Spleen Cells and Human Peripheral Lymphocytes

1970 • 385 citations

Guanosine 3′:5′-Cyclic Monophosphate: A Possible Intracellular Mediator of Mitogenic Influences in Lymphocytes

1972 • 381 citations

DEMONSTRATION OF MOUSE ISOANTIGENS AT THE CELLULAR LEVEL BY THE FLUORESCENT ANTIBODY TECHNIQUE

1961 • 367 citations

ROLE OF COMPLEMENT IN INDUCTION OF ANTIBODY PRODUCTION IN VIVO

1974 • 357 citations

LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES

1972 • 349 citations

CELL SEPARATION ON ANTIGEN-COATED COLUMNS

1969 • 320 citations

Activation of T and B Lymphocytes by Insoluble Phytomitogens

1972 • 318 citations

THE MITOGENIC EFFECT OF LIPOPOLYSACCHARIDE ON BONE MARROW-DERIVED MOUSE LYMPHOCYTES

1973 • 310 citations

BIOLOGICAL EXPRESSIONS OF LYMPHOCYTE ACTIVATION

1973 • 286 citations

THE RELATIONSHIP BETWEEN ANTIGENIC STRUCTURE AND THE REQUIREMENT FOR THYMUS-DERIVED CELLS IN THE IMMUNE RESPONSE

1971 • 282 citations

SURFACE ALLOANTIGENS OF PLASMA CELLS

1970 • 281 citations

Evidence for thymus-independent humoral antibody production in mice against polyvinylpyrrolidone and E. coli lipopolysaccharide

1971 • 280 citations

Immunological Unresponsiveness

1973 • 278 citations

IMMUNOGLOBULINS ON THE SURFACE OF LYMPHOCYTES

1971 • 276 citations

INHIBITORY AND STIMULATORY EFFECTS OF CONCANAVALIN A ON THE RESPONSE OF MOUSE SPLEEN CELL SUSPENSIONS TO ANTIGEN

1972 • 275 citations

A MOUSE B-CELL ALLOANTIGEN DETERMINED BY GENE(S) LINKED TO THE MAJOR HISTOCOMPATIBILITY COMPLEX

1973 • 274 citations

Immunological Specificity

1959 • 270 citations

PPD Tuberculin—a B-Cell Mitogen

1972 • 267 citations

CELL INTERACTIONS IN THE IMMUNE RESPONSE IN VITRO

1972 • 253 citations

DIFFERENTIATION OF T CELLS INDUCED BY PREPARATIONS FROM THYMUS AND BY NONTHYMIC AGENTS

1973 • 252 citations

Requirement of Thymus-dependent Lymphocytes for Potentiation by Adjuvants of Antibody Formation

1971 • 245 citations

Antigen-induced selective recruitment of circulating lymphocytes

1971 • 239 citations

Guanosine 3′:5′-Cyclic Monophosphate and the Action of Insulin and Acetylcholine

1973 • 232 citations

ACTIVATION OF T AND B LYMPHOCYTES IN VITRO

1974 • 231 citations

MECHANISM OF THYMUS-INDEPENDENT IMMUNOCYTE TRIGGERING

1974 • 230 citations

ANTIGENS IN IMMUNITY

1964 • 227 citations

B Cell Mitogenic Properties of Thymus-independent Antigens

1973 • 224 citations

Cyclic GMP and Cell Movement

1973 • 218 citations

Tolerance, Enhancement and the Regulation of Interactions Between T Cells, B Cells and Macrophages

1972 • 208 citations

Evidence for the existence of two functionally distinct types of cells which regulate the antibody response to type 3 pneumococcal polysaccharide.

1970 • 201 citations

Activation of B lymphocytes by locally concentrated concanavalin A

1972 • 198 citations

Thymus Dependence of Antibody Response: Variation with Dose of Antigen and Class of Antibody

1968 • 195 citations

Genetic Control of Immune Responsiveness

1971 • 192 citations

CARRIER FUNCTION IN ANTI-HAPTEN ANTIBODY RESPONSES

1971 • 190 citations

LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECITLES

1972 • 190 citations

Control of Cell Surface Topography

1974 • 185 citations

Lymphocyte structure and function

1978 • 184 citations

Effect of Antigen Binding on the Properties of Antibody

1974 • 182 citations

THE LIFE-SPAN AND RECIRCULATION OF MARROW-DERIVED SMALL LYMPHOCYTES FROM THE RAT THORACIC DUCT

1972 • 182 citations

Studies on immunological paralysis

1971 • 182 citations

Molecular Packing in Collagen

1971 • 174 citations

Relationship of the Structure of Bacterial Lipopolysaccharides to Its Function in Mitogenesis and Adjuvanticity

1973 • 172 citations

ACTIVATION OF T AND B LYMPHOCYTES IN VITRO

1974 • 172 citations

Stimulation of a T-Independent Primary Anti-Hapten Response in Vitro by TNP-Lipopolysaccharide (TNP-LPS)

1975 • 170 citations

The immune system: Genes, receptors, signals

1973 • 169 citations

Inhibition of mitogenic stimulation of mouse lymphocytes by anti‐mouse immunoglobulin antibodies. I. Mode of action

1974 • 165 citations

MOUSE THYMUS-INDEPENDENT AND THYMUS-DERIVED LYMPHOID CELLS

1972 • 164 citations

CELL INTERACTIONS IN THE IMMUNE RESPONSE IN VITRO

1972 • 162 citations

Receptors for Immune Complexes on Lymphocytes

1974 • 160 citations

Production by Stimulated Macrophages of Factors depressing Lymphocyte Transformation

1973 • 160 citations

Cyclic Nucleotides as Intracellular Mediators of the Expression of Antigen-sensitive Cells

1973 • 159 citations

CELL SURFACE IMMUNOGLOBULIN

1972 • 158 citations

Bound C3 as the second signal for B-cell activation

1973 • 158 citations

REGULATION OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE

1973 • 157 citations

General Method for the Detection of Cells producing Antibodies against Haptens and Proteins

1970 • 155 citations

Immune Response Restoration with Macrophage Culture Supernatants

1971 • 155 citations

“Spontaneous” B cell activation due to loss of normal mouse serum suppressor

1972 • 155 citations

THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY

1964 • 152 citations

θ-bearing Lymphocytes in Nude Mice

1973 • 150 citations

Regulation of antibody synthesis against Escherichia coli endotoxin. I. Suppressive effect of endogenously produced and passively transferred antibodies.

1968 • 149 citations

Selective triggering of B cell subpopulations by mitogens

1974 • 146 citations

Relationship Between Antigen and Antibody‐Induced Suppression of Immunity

1972 • 146 citations

Molecular Biology of Cellular Membranes with Applications to Immunology

1974 • 144 citations

Lipopolysaccharide can substitute for helper cells in the antibody response in vitro

1972 • 143 citations

Mouse Specific Bone Marrow-derived Lymphocyte Antigen as a Marker for Thymus-independent Lymphocytes

1971 • 143 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE

1972 • 142 citations

Frequency of antigen-sensitive cells to thymus-independent antigens

1971 • 140 citations

CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE

1971 • 140 citations

INDUCTION OF IMMUNITY AND TOLERANCE IN VITRO BY HAPTEN PROTEIN CONJUGATES

1972 • 139 citations

Evidence for the Existence of Two Functionally Distinct Types of Cells Which Regulate the Antibody Response to Type III Pneumococcal Polysaccharide

1970 • 139 citations

TERMINATION OF TOLERANCE TO HUMAN GAMMA GLOBULIN IN MICE BY ANTIGEN AND BACTERIAL LIPOPOLYSACCHARIDE (ENDOTOXIN)

1973 • 135 citations

IMMUNOLOGICAL TOLERANCE IN BONE MARROW-DERIVED LYMPHOCYTES

1972 • 134 citations

CELLULAR REQUIREMENTS FOR THE PRIMARY IN VITRO ANTIBODY RESPONSE TO DNP-FICOLL

1974 • 134 citations

THE USE OF BACTERIAL LIPOPOLYSACCHARIDES TO SHOW THAT TWO SIGNALS ARE REQUIRED FOR THE INDUCTION OF ANTIBODY SYNTHESIS

1973 • 133 citations

INHIBITORY AND STIMULATORY EFFECTS OF CONCANAVALIN A ON THE RESPONSE OF MOUSE SPLEEN CELL SUSPENSIONS TO ANTIGEN

1973 • 133 citations

Blocking of the Lymphocyte Receptor Site for Cell Mediated Hypersensitivity and Transplantation Reactions by Anti-light Chain Sera

1969 • 133 citations

Enhanced immune responsiveness to a thymus‐independent antigen early after adult thymectomy: Evidence for short‐lived inhibitory thymus‐derived cells

1972 • 132 citations

Requirement for Cross-Linkage in the Stimulation of Transformation of Rabbit Peripheral Lymphocytes by Antiglobulin Reagents

1970 • 131 citations

In vitro activation of mouse lymphocytes in serum-free medium: effect of T and B cell mitogens on proliferation and antibody synthesis

1973 • 130 citations

Inhibition of secondary anti‐hapten responses with the hapten conjugated to type 3 pneumococcal polysaccharide

1972 • 128 citations

INDUCTION OF A HEMOLYSIN RESPONSE IN VITRO

1970 • 126 citations

Effect of the number of haptens coupled to each erythrocyte on haemolytic plaque formation.

1969 • 126 citations

Characterization of the antibody-dependent cytotoxic cell. A non-phagocytic monocyte?

1973 • 125 citations

INTERACTION OF HUMAN THYMUS-DERIVED AND NON-THYMUS-DERIVED LYMPHOCYTES IN VITRO

1973 • 122 citations

19S Antibody Production against Soluble Lipopolysaccharide Antigens by Individual Lymphoid Cells In Vitro

1965 • 120 citations

IMMUNE RESPONSES IN VITRO

1971 • 119 citations

ANTIBODY-MEDIATED SUPPRESSION OF THE IMMUNE RESPONSE IN VITRO

1970 • 118 citations

Precursor cells specific to sheep red cells in nude mice. estimation of frequency in the microculture system

1973 • 118 citations

Morphological and Functional Aspects of Immunity

1971 • 116 citations

A QUANTITATIVE ASSAY FOR THE PROGENITORS OF BONE MARROW-ASSOCIATED LYMPHOCYTES

1972 • 115 citations

EFFECTOR CELL BLOCKADE

1974 • 114 citations

Differentiation of B Cells: Sequential Appearance of Responsiveness to Polyclonal Activators

1974 • 112 citations

MECHANISM OF ACTIVATION OF THE BONE MARROW-DERIVED LYMPHOCYTE

1973 • 111 citations

REGULATION OF LYMPHOCYTE RESPONSES IN VITRO

1972 • 110 citations

THE ABILITY OF BACTERIAL LIPOPOLYSACCHARIDE TO MODULATE THE INDUCTION OF UNRESPONSIVENESS TO A STATE OF IMMUNITY

1973 • 108 citations

A NEW SURFACE MARKER ON T LYMPHOCYTES OF HUMAN PERIPHERAL BLOOD

1973 • 108 citations

Induction of DNA synthesis in human lymphocytes: interaction between non-specific mitogens and antigens.

1970 • 107 citations

BIOLOGICAL EXPRESSIONS OF LYMPHOCYTE ACTIVATION

1973 • 104 citations

Summary: Waiting for the End

1967 • 102 citations

PURIFIED PROTEIN DERIVATIVE OF TUBERCULIN INDUCES IMMUNOGLOBULIN PRODUCTION IN NORMAL MOUSE SPLEEN CELLS

1973 • 102 citations

Molecular Basis of B‐Cell Activation

1974 • 102 citations

Origin and molecular size of immunoglobulin-A in the mesenteric lymph of the dog.

1970 • 102 citations

Mouse Myelomas producing Precipitating Antibody to Nucleic Acid Bases and/or Nitrophenyl Derivatives

1968 • 102 citations

Mechanism of binding of soluble immune complexes to lymphocytes

1973 • 100 citations

Rocket‐Line Immunoelectroplioresis (76)

1973 • 100 citations

Studies on immunological paralysis. IX. The immunogenicity and tolerogenicity of levan (polyfructose) in mice.

1972 • 98 citations

Biochemistry of cell differentiation

1973 • 98 citations

EFFECT OF B-CELL MITOGENS ON LYMPHOCYTE SUBPOPULATIONS POSSESSING C'3 AND Fc RECEPTORS

1974 • 97 citations

Regulation of Antibody Synthesis Against Escherichia Coli Endotoxin

1968 • 96 citations

COMPLEMENT-DEPENDENT B-CELL ACTIVATION BY COBRA VENOM FACTOR AND OTHER MITOGENS?

1974 • 95 citations

Cellular Site of Action of Various Adjuvants in Antibody Responses to Hapten-Carrier Conjugates

1973 • 94 citations

The Tolerant Cell: Direct Evidence for Receptor Blockade by Tolerogen

1974 • 93 citations

Variable Effects of Anti-Lymphocyte Serum on Humoral Antibody Formation: Role of Thymus Dependency of Antigen

1971 • 93 citations

Mitogenicity of Bacterial Endotoxins: Characterization of the Mitogenic Principle

1973 • 92 citations

Cell Interactions and Receptor Antibodies in Immune Responses.

1973 • 92 citations

Hapten competition and the nature of cell-cooperation in the antibody response

1971 • 91 citations

Cell Interaction in an Immune Response in vitro: Requirement for Theta-Carrying Cells

1970 • 90 citations

Staphylococci and Staphylococcal Infections: Recent Progress

1975 • 90 citations

Requirement for adherent cells in the primary and secondary immune response in vitro

1972 • 89 citations

IgM in bone marrow‐derived lymphocytes. Synthesis, surface deposition, turnover and carbohydrate composition in unstimulated mouse B cells

1974 • 89 citations

The role of humoral factors in the initiation of in vitro primary immune responses. II. Effects of lymphocyte mitogens.

1973 • 88 citations

Role of C3 in in vitro lymphocyte cooperation

1974 • 87 citations

Lipopolysaccharides can convert heterologous red cells into thymus-independent antigens

1972 • 87 citations

IgM in bone marrow-derived lymphocytes. Changes in synthesis, turnover and secretion, and in numbers of molecules on the surface of B cells after mitogenic stimulation

1974 • 86 citations

Stimulation of DNA synthesis in mouse lymphoid cells by polyanionsin vitro. I. Target cells and possible mode of action

1973 • 86 citations

Regulation of the Antibody Response to Type III Pneumococcal Polysaccharide

1974 • 86 citations

T Cells Can Bind Antigen via Cytophilic IgM Antibody Made by B Cells

1973 • 85 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE

1972 • 84 citations

Lymphocyte activation. V. Quantitation of the proliferative responses to mitogens using defined T and B cell populations.

1973 • 83 citations

Maturation of mitogen-activated bone marrow-derived lymphocytes in the absence of proliferation

1974 • 81 citations

Non-specific cytotoxicity by T cells activated with plant mitogens in vitro and the requirement for plant agents during the killing reaction.

1973 • 81 citations

Induction of Immunity and Tolerance in vitro in the Absence of Phagocytic Cells

1970 • 80 citations

IMMUNE RESPONSE TO A HAPTEN COUPLED TO A NONIMMUNOGENIC CARRIER

1972 • 79 citations

Thymus-Independence of Slowly Metabolized Immunogens

1972 • 78 citations

INITIATION OF ANTIBODY RESPONSES BY DIFFERENT CLASSES OF LYMPHOCYTES

1972 • 76 citations

The requirement for macrophages in the secondary immune response to antigens of small and large size in vitro.

1971 • 76 citations

The role of humoral factors in the initiation of in vitro primary immune responses. 3. Characterization of factors that replace thymus-derived cells.

1973 • 75 citations

CONTRIBUTION OF DIFFERENT CELL TYPES TO THE GENETIC CONTROL OF IMMUNE RESPONSES AS A FUNCTION OF THE CHEMICAL NATURE OF THE POLYMERIC SIDE CHAINS (POLY-L-PROLYL AND POLY-DL-ALANYL) OF SYNTHETIC IMMUNOGENS

1972 • 75 citations

Biochemistry of cell differentiation II

1977 • 73 citations

The immunological properties of haptens coupled to thymus-independent carrier molecules. I. The characteristics of the immune response to dinitrophenyllysinesubstituted pneumococcal polysaccharide (SIII) and levan

1974 • 72 citations

FUNCTIONAL CHARACTERISTICS OF PEYER'S PATCH LYMPHOID CELLS

1974 • 69 citations

Induction of Immunoglobulin M Synthesis and Secretion in Bone-Marrow-Derived Lymphocytes by Locally Concentrated Concanavalin A

1973 • 69 citations

Genetic control of the immune response in mice. 3. An association between H-2 type and reaction to H-Y.

1971 • 68 citations

When Allogeneic Mouse Spleen Cells Are Mixed in Vitro the T‐Cells Secrete a Product Which Guides the Maturation of B‐Cells

1972 • 67 citations

Ly-4 , A New Locus Determining a Lymphocyte Cell-Surface Alloantigen in Mice

1973 • 65 citations

Inhibition of Local Graft-versus-Host Reaction by Anti-Alloantibodies

1973 • 65 citations

Selective Stimulation of IgM Synthesis in Mouse B Lymphocytes by Pokeweed Mitogen

1972 • 65 citations

Induction of immunity and tolerance in vitro by hapten protein conjugates. II. Carrier independence of the response to dinitrophenylated polymerized flagellin

1972 • 65 citations

ANTIBODY AND IMMUNOGLOBULIN PRODUCTION AT THE CELLULAR LEVEL IN BURSECTOMIZED-IRRADIATED CHICKENS

1969 • 65 citations

IMMUNOLOGICAL TOLERANCE TO A HAPTEN

1973 • 65 citations

Cell interactions in the immune response in vitro. I. Metabolic activities of T cells in a collaborative antibody response

1972 • 62 citations

Immunocyte triggering

1970 • 61 citations

The Antigen Receptor Problem

1970 • 61 citations

Studies on immunological paralysis. II. The detection and significance of antibod-forming cells in the spleen during immunological paralysis with type 3 pneumococcal polysaccharide.

1969 • 61 citations

CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE

1971 • 60 citations

The Role of Humoral Factors in the Initiation of in Vitro Primary Immune Responses

1973 • 60 citations

SPECIFICITY OF THE IMMUNE RESPONSE TO THE 2, 4-DINITROPHENYL AND 2, 4, 6-TRINITROPHENYL GROUPS

1969 • 60 citations

The transformation of human lymphocytes by monkey antisera to human immunoglobulins.

1969 • 60 citations

Affinity of T and B lymphocyte receptors for hapten determinants

1973 • 59 citations

INDUCTION OF B CELL TOLERANCE IN VITRO TO 2,4-DINITROPHENYL COUPLED TO A COPOLYMER OF <scp>D</scp>-GLUTAMIC ACID AND <scp>D</scp>-LYSINE (DNP-<scp>D</scp>-GL)

1973 • 59 citations

Quantitative estimation of antibody in the immunoglobulin classes of the mouse. II. Thymic dependence of the different classes.

1972 • 58 citations

Mitogen‐induced lymphocyte‐mediated cytotoxicity in vitro: Effect of mitogens selectively activating T or B cells

1972 • 58 citations

ANTIGEN-BINDING CELLS IN MICE IMMUNE OR TOLERANT TO ESCHERICHIA COLI POLYSACCHARIDE

1971 • 57 citations

Reconstitution of t cell-depleted spleen cell populations by factors derived from t cells. I. Conditions for the production of active t cell supernatants.

1973 • 56 citations

REGULATION OF ANTIBODY SYNTHESIS AGAINST ESCHERICHIA COLI ENDOTOXIN

1969 • 55 citations

A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes

1971 • 55 citations

IMMUNOLOGICAL MEMORY IN MICE

1972 • 55 citations

Stimulation of chicken lymphocytes in a serum-free medium

1972 • 55 citations

Demonstration of Proliferation by Bone Marrow-Derived Lymphocytes of Guinea Pigs, Mice and Rabbits in Response to Mitogen Stimulation in Vitro

1973 • 55 citations

RESTRICTION OF SPECIFICITY IN THE PRECURSORS OF BONE MARROW-ASSOCIATED LYMPHOCYTES

1973 • 55 citations

Mode of Action of a Supernatant Activity from T-Cell Cultures that Nonspecifically Stimulates the Humoral Immune Response

1974 • 54 citations

Insulin-Sepharose and the Dynamics of Insulin Action

1971 • 54 citations

Studies on immunological paralysis. V. The influence of molecular weight on the immunogenicity, tolerogenicity and antibody-neutralizing activity of the 3 pneumococcal polysaccharide.

1971 • 54 citations

Anti‐hapten antibodies in normal sera

1971 • 54 citations

The differentiation function of T cell‐replacing factor in nu/nu spleen cell cultures

1974 • 54 citations

IN VITRO-INITIATED SECONDARY ANTI-HAPTEN RESPONSE

1970 • 53 citations

Binding of Helix Pomatia A Hemagglutinin to Human Erythrocytes and their Cells. Influence of Multivalent Interaction on Affinity

1973 • 53 citations

Rabbit Blood Lymphocytes May Be T Cells with Surface Immunoglobulins

1973 • 52 citations

Studies on immunological paralysis IV. The relative contributions of continuous antibody neutralization and central inhibition to paralysis with type III pneumococcal polysaccharide

1971 • 51 citations

Lymphocyte activation. IV. The ultrastructural pattern of the response of mouse T and B cells to mitogenic stimulation in vitro.

1973 • 51 citations

Lymphocytes and Immunoglobulins

2015 • 50 citations

Antibodies with Multiple Binding Functions. Induction of Single Immunoglobin Species by Structurally Dissimilar Haptens

1973 • 50 citations

MITOGENIC EFFECT BY LIPOPOLYSACCHARIDE AND POKEWEED LECTIN ON DENSITY-INHIBITED CHICK EMBRYO FIBROBLASTS

1973 • 50 citations

Regulation of the Antibody Response to Type III Pneumococcal Polysaccharide

1974 • 49 citations

Thymus cell population exerting a regulatory function in the immune response of mice to polyvinyl pyrrolidone

1974 • 48 citations

CONTRIBUTION OF BONE MARROW CELLS AND LACK OF EXPRESSION OF THYMOCYTES IN GENETIC CONTROLS OF IMMUNE RESPONSES FOR TWO IMMUNOPOTENT REGIONS WITHIN POLY-(PHE,GLU)-POLY-PRO--POLY-LYS IN INBRED MOUSE STRAINS

1971 • 48 citations

AUTORADIOGRAPHIC STUDIES ON THE PROLIFERATION OF ANTIBODY-PRODUCING CELLS IN VITRO

1974 • 48 citations

The Role of Humoral Factors in the Initiation of in Vitro Primary Immune Responses

1973 • 48 citations

The Effect of Capping by Anti‐immunoglobulin Antibody on the Expression of Cell Surface Immunoglobulin and on Lymphocyte Activation

1973 • 47 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE

1973 • 46 citations

SPECIFIC ACTIVATION OF THE BONE MARROW-DERIVED LYMPHOCYTE BY ANTIGEN PRESENTED IN A NON-MULTIVALENT FORM

1973 • 46 citations

Soluble mediators of t‐b interaction

1973 • 46 citations

HUMORAL AND CELL MEDIATED RESPONSES IN VITRO OF SPLEEN CELLS FROM MICE WITH THYMIC APLASIA (NUDE MICE)

1972 • 46 citations

Quantitation of the number of mitogen molecules activating DNA synthesis in T and B lymphocytes.

1973 • 45 citations

The Immune Response in Mice to the Haptenic Determinant Dnp Coupled to a Thymus-Independent Carrier (Levan)

1972 • 45 citations

Reconstitution of T Cell-Depleted Spleen Cell Populations by Factors Derived from T Cells

1973 • 44 citations

Immunoglobulin Synthesis and Secretion by Cells in the Mouse Thymus That Do Not Bear θ Antigen

1973 • 43 citations

Lymphocyte Transformation by H-Chain Specific Anti-immunoglobulin Sera

1969 • 43 citations

The immune response to a simple antigenic determinant.

1966 • 43 citations

Differential morphology of mouse spleen cells stimulated in vitro by endotoxin, phytohemagglutinin, pokeweed mitogen and staphylococcal enterotoxin B.

1973 • 43 citations

Mitogenic Properties of Pea Lectin and Its Chemical Derivatives

1973 • 43 citations

Studies on immunological paralysis. X. Cellular characteristics of the induction and loss of tolerance to levan (Polyfructose).

1972 • 42 citations

Antigen Binding Cells in Tolerant Animals

1970 • 42 citations

Immunology: What are the rules of the game?

1972 • 41 citations

Antigenic competition in vitro between heterologous erythrocytes

1972 • 41 citations

Responses of athymic (“nude”) mice to sheep red blood cells

1972 • 40 citations

Effect of PPD on the Specific Immune Response to Heterologous Red Cells in Vitro

1974 • 39 citations

Changes in Membrane Structure Associated with Cell Contact

1973 • 39 citations

Studies on human lymphocytes stimulated in vitro with anti-γ and anti-μ antibodies

1967 • 38 citations

Complement Independence of Stimulation of Mouse Splenic B Lymphocytes by Mitogens

1973 • 38 citations

Immunoglobulin-like surface molecules and theta antigen during the specific and non-specific stimulation of mouse spleen cells in vitro.

1972 • 37 citations

Induction of Immunity and Immunologic Paralysis in Mice against Polyvinyl Pyrrolidone

1969 • 37 citations

Surface immunoglobulin on rabbit lymphoid cells

1974 • 36 citations

Mitogenic Factors Produced by Lymphocyte Activation: Effect on T- and B-Cells

1972 • 35 citations

Cellular Events During the Formation of Antibody

1967 • 35 citations

Stimulation of DNA synthesis in mouse lymphoid cells by polyanions in vitro. II. Relationship between adjuvant activity and stimulation of DNA synthesis by polyanions

1973 • 32 citations

The Immune Capacity of Lymphocytes after Cross-Linking of Surface Immunoglobulin Receptors by Antibody

1972 • 32 citations

The response of leucocytes of agammaglobulinaemia subjects to phythohaemagglutinin and anti-immunoglobulin antiserum.

1969 • 32 citations

Mammalian Cells: Probes and Problems

1976 • 32 citations

Dose Dependence of Antigen Binding to B and T Lymphocytes

1974 • 32 citations

Specificity of Hapten‐Reactive T and B Mouse Lymphocytes

1974 • 31 citations

Thymus dependence of the immune response: response to the haptenic determinant NIP in mice.

1971 • 30 citations

The interactions of mitogens with lymphoid cells and the effect of neuraminidase on the cells' responsiveness to stimulation

1972 • 30 citations

Mechanism of B‐Lymphocyte Activation: Failure to Obtain Evidence of a Direct Role of the Ig Receptors in the Triggering Process

1975 • 30 citations

Dynamic Aspects of Antigen Binding to B Cells in Immune Induction

1972 • 30 citations

The in Vitro Response of Chicken B Cell Populations to Lipopolysaccharide

1973 • 30 citations

Conservatism in the Evolution of Immunoglobulin

1972 • 29 citations

Direct evidence for the response of B and T cells to pokeweed mitogen

1973 • 29 citations

Quantitative Estimation of Antibody in the Immunoglobulin Classes of the Mouse

1972 • 29 citations

SYNTHESIS, INTRACELLULAR DISTRIBUTION, AND SECRETION OF IMMUNOGLOBULIN AND H-2 ANTIGEN IN MURINE SPLENOCYTES

1973 • 28 citations

Differentiation of Lymphoid Cells: Effect of Serum and Other Mitogenic Agents on the Selective Induction of Immunoglobulin M Secreting Lymph Node Cells in Tissue Culture

1973 • 28 citations

Reconstitution of immunocompetence in B cells by addition of concanavalin A or concanavalin A-treated thymus cells.

1973 • 27 citations

Evidence for the presence in unimmunized mice of two populations of bone marrow derived B lymphocytes, defined by differences in adherence properties

1974 • 26 citations

Specific heterologous enhancement of immune responses. V. Isolation of a soluble enhancing factor from supernatants of specifically stimulated and allogeneically induced lymphoid cells.

1973 • 26 citations

The Early Stimulation of Protein Synthesis in Sensitized Guinea Pig Lymph Node Cells by Antigen

1972 • 25 citations

The mechanism of bone marrow‐derived (B) lymphocyte activation. II. A “second signal” for antigen‐specific activation provided by flagellin and lipopolysaccharide

1974 • 25 citations

Mechanism of B‐Cell Activation and Paralysis by Thymus‐Independent Antigens

1975 • 25 citations

Culture of mouse lymphoid cells in serum-free medium

1972 • 25 citations

Studies on immunological paralysis. XI. A comparison of the tolerogenicity in vitro of levan and type 3 pneumococcal polysaccharide

1973 • 23 citations

STUDIES ON ANTIBODY-PRODUCING CELLS

1971 • 23 citations

Kinetics of in vitro initiated secondary anti-hapten response: induction of plaque-forming cells by soluble and particulate antigen

1970 • 23 citations

Allogeneic interactions in the immune response and tolerance

1974 • 22 citations

Immunological unresponsiveness against the 4‐Hydroxy‐3,5‐dinitro‐phenacetyl (NNP) hapten in different lymphoid cell populations

1971 • 22 citations

Abnormal Visual Function in Xenopus following Stroboscope Illumination

1973 • 21 citations

Primary antibody formation in vitro by mouse cells in a complete homologous system

1973 • 21 citations

The role of humoral factors in the initiation of in vitro primary immune responses. I. Effects of deficient fetal bovine serum.

1973 • 19 citations

Regional Lymph Node Irradiation: Effect on Local and Distant Generation of Antibody Forming Cells

1973 • 18 citations

Antigenic Competition Between Heterologous Erythrocytes

1971 • 18 citations

The mechanism of bone marrow‐derived (B) lymphocyte activation. I. Early events in antigen‐induced triggering in the presence of polymerized flagellin

1974 • 18 citations

Direct conversion of precursors of PFCs into active PFCs in vitro, without prior cell division.

1973 • 17 citations

Hapten‐induced paralysis. I. Evidence for the persistence of hapten‐specific immunocompetent B lymphocytes in specifically paralyzed mice

1974 • 17 citations

Pleistocene River Gravels and the Stonehenge Problem

1973 • 17 citations

Density gradient separation of chicken thymus cells

1973 • 16 citations

The Immune Response Against Hapten-Autologous Protein Conjugates in the Mouse

1973 • 16 citations

The lipid A immunity system. I. Induction of heterophile antibodies by enterobacterial lipopolysaccharides and their lipid A component

1972 • 16 citations

The immune response against hapten-autologous protein conjugates in the mouse. IV. Thymus dependency of the primary response to hapten-autologous albumin conjugates.

1973 • 16 citations

The immunological properties of haptens coupled to thymus‐independent carrier molecules. II. The influence of the graft‐versus‐host reaction on primary antibody responses to hapten‐coupled polysaccharides and proteins

1974 • 15 citations

INDUCTION OF IgG BY LIPID A IN THE NEWBORN MOUSE

1974 • 15 citations

Ciba Foundation Symposium 18 - Immunopotentiation

1973 • 14 citations

The Role of Humoral Factors in the Initiation of in Vitro Primary Immune Responses

1973 • 14 citations

Effect of Polyspecific Rabbit Anti-Immunoglobulin Antisera on the Response of Human Lymphocytes in Mixed Lymphocyte Culture

1971 • 13 citations

Antigen-induced deoxyribonucleic acid synthesis in mouse lymphocytes. I. The nature and specificity of lymphocyte activation by hemocyanin and dinitrophenyl carrier conjugates.

1973 • 13 citations

Mouse Spleen Cells Cultivated in Homologous Serum Can Make Primary Antibodies in Vitro Provided the T‐Cells Are Non‐Specifically Activated

1972 • 13 citations

Unmasking and Functional Characterization of T ‐Cell‐Replacing Factors Obtained from Super‐natants of Allogeneic Spleen Cell Mixtures

1974 • 12 citations

Antigenic Composition, Not the Degree of Polymerization, Determines the Requirement for Thymus-Derived Cells in Immune Responses to Salmonella Flagellar Proteins

1974 • 12 citations

STUDIES ON ANTIBODY-PRODUCING CELLS

1971 • 11 citations

Antigen-Induced Deoxyribonucleic Acid Synthesis in Mouse Lymphocytes

1973 • 11 citations

Response of mice to rabbit Fab' 2 and Fab'. Thymus independence of IgM response and thymus dependence of IgG response.

1972 • 10 citations

Anti‐hapten response in vitro. Affinity differences in precursors of anti‐hapten antibody‐producing cells

1971 • 10 citations

Specific Heterologous Enhancement of Immune Responses

1973 • 10 citations

How to Reform the FDA

1971 • 10 citations

IgM anamnestic immune response to the haptenic determinant DNP on a thymus-independent carrier.

1974 • 10 citations

The effect of erythrocyte antigen structure on requirement for T cells.

1974 • 10 citations

From Cyclic AMP to Cyclic GMP

1973 • 10 citations

A Factor That Can be Used to Regulate an In Vitro Primary Immune Response

1972 • 9 citations

Identification of Direct Hemolytic Plaques as IgM or IgG Plaques by Hapten Inhibition

1971 • 9 citations

Effect of Locally Administered Endotoxin on Regenerating Appendix Structure and Responses of Appendix Cells to Mitogens

1973 • 7 citations

IgM Anamnestic Immune Response to the Haptenic Determinant DNP on a Thymus-Independent Carrier

1974 • 7 citations

Complement and immunoglobulin levels in the serum and thoracic duct lymph of the rat

1973 • 7 citations

Mixed Leukocyte Culture with Mouse Spleen Cells in a Serum-Free Medium

1972 • 6 citations

The allogeneic effect in vitro: activation of antibody synthesis in aggressor and target lymphocyte populations by allogeneic interaction

1973 • 6 citations

Structural changes in sheep antibody induced by interaction with polypeptide antigens.

1973 • 5 citations

Quantity and Quality of Anti‐Hapten Antibodies in Normal and in T Cell‐Deprived Mice Studied at the Cellular Level

1972 • 4 citations

Misidentification or Misunderstanding?

1973 • 1 citations