Cells Inducing Tolerance to Mls and H-2 Antigens

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

1988 • 491 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex product

1987 • 408 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.

1989 • 331 citations

Induction of classical transplantation tolerance in the adult.

1989 • 325 citations

Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: Application in the production of chimeric thymus rudiments

1982 • 324 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

Differential activation requirements for virgin and memory T cells.

1988 • 271 citations

The Influence of Thymus H-2 Antigens on the Specificity of Maturing Killer and Helper Cells

1978 • 257 citations

Function and Specificity of T Cell Subsets in the Mouse

1987 • 208 citations

Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells

1984 • 158 citations

Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells.

1989 • 156 citations

Veto Cells

1988 • 150 citations

Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.

1990 • 146 citations

STUDIES OF THE ROLE OF THE THYMIC ENVIRONMENT IN THE INDUCTION OF TOLERANCE TO MHC ANTIGENS

1985 • 127 citations

Preferential expression of the T-cell receptor Vβ3 gene by Mlsc reactive T cells

1988 • 123 citations

Induction of Neonatal Tolerance to Mls^aAntigens by CD8⁺T Cells

1990 • 103 citations

Self-tolerance alters T-cell receptor expression in an antigen-specific MHC restricted immune response

1988 • 101 citations

Specific binding of alloantigens to T cells activated in the mixed lymphocyte reaction.

1976 • 98 citations

Expression of M locus differences by B cells but not T cells

1974 • 97 citations

Restricted tissue distribution of Mlsa determinants. Stimulation of Mlsa-reactive T cells by B cells but not by dendritic cells or macrophages.

1989 • 90 citations

The immunobiology of the T cell response to Mls-locus-disparate stimulator cells. I. Unidirectionality, new strain combinations, and the role of Ia antigens.

1985 • 85 citations

Clonal deletion of self-reactive T cells in irradiation bone marrow chimeras and neonatally tolerant mice. Evidence for intercellular transfer of Mlsa.

1989 • 76 citations

Surprisingly uneven distribution of the T cell receptor V beta repertoire in wild mice.

1990 • 69 citations

The immunobiology of T cell responses to Mls-locus-disparate stimulator cells. II. Effects of Mls-locus-disparate stimulator cells on cloned, protein antigen-specific, Ia-restricted T cell lines.

1985 • 65 citations

Split tolerance induced by the intrathymic adoptive transfer of thymocyte stem cells.

1988 • 59 citations

Regulatory T Lymphocytes

1980 • 56 citations

Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes.

1976 • 54 citations

Capacity of unprimed CD4+ and CD8+ T cells expressing V beta 11 receptors to respond to I-E alloantigens in vivo.

1989 • 53 citations

Studies on non-H-2-linked lymphocyte-activating determinants. II. Nonexpression of Mls determinants in a mouse strain with an X-linked B lymphocyte immune defect.

1976 • 51 citations

Capacity of small B cell‐enriched populations to stimulate mixed lymphocyte reactions: marked differences between irradiated vs. mitomycin C‐treated stimulators

1985 • 51 citations

Macrophages and T cells do not express Mlsa determinants.

1989 • 47 citations

The Mls system.

1976 • 39 citations

Negative and positive selection of immature thymocytes: timing and the role of the ligand for alpha beta T cell receptor.

1990 • 39 citations

Acquisition of the T cell repertoire

1978 • 30 citations

Specifically Decreased MLC Response of Lymphocytes from CBA Mice Injected with Cells from the H-2-Compatible, M-Antigen-Incompatible Strain C3H.

1975 • 27 citations

STUDIES ON NON‐H‐2 LINKED LYMPHOCYTE ACTIVATING DETERMINANTS I. DESCRIPTION OF THE CELL TYPE BEARING THE MLS PRODUCT

1977 • 27 citations

T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes.

1985 • 24 citations

T‐Cell Responses and Tolerance to Mls^a Determinants

1989 • 24 citations

Neonatal tolerance induction to Mlsa

1988 • 12 citations

Analysis of T hybridomas prepared from a T cell clone with three specificities. Recognition of self + X and allo-H-2 determinants segregates from recognition of Mlsa determinants.

1988 • 8 citations

Neonatal tolerance induction to Mlsa

1988 • 7 citations

A Third Set of Genes Regulates Thymic Selection

1989 • 7 citations