Role of Antigen Structure in the Discrimination between Tolerance and Immunity by B Cells

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Control of proliferation in animal cells

1974 • 1,177 citations

Thymus-Independent B-Cell Induction and Paralysis

1975 • 304 citations

Immune Activation of B Cells: Evidence for‘One Nonspecific Triggering Signal' Not Delivered by the Ig Receptors

1974 • 244 citations

Evidence for the existence of two functionally distinct types of cells which regulate the antibody response to type 3 pneumococcal polysaccharide.

1970 • 201 citations

Activation of B lymphocytes by locally concentrated concanavalin A

1972 • 198 citations

Studies on immunological paralysis

1971 • 182 citations

The immune system: Genes, receptors, signals

1973 • 169 citations

Cyclic Nucleotides as Intracellular Mediators of the Expression of Antigen-sensitive Cells

1973 • 159 citations

Relationship Between Antigen and Antibody‐Induced Suppression of Immunity

1972 • 146 citations

Evidence for the Existence of Two Functionally Distinct Types of Cells Which Regulate the Antibody Response to Type III Pneumococcal Polysaccharide

1970 • 139 citations

INDUCTION OF IMMUNITY AND TOLERANCE IN VITRO BY HAPTEN PROTEIN CONJUGATES

1972 • 139 citations

IMMUNOLOGICAL TOLERANCE IN BONE MARROW-DERIVED LYMPHOCYTES

1972 • 134 citations

Enhanced immune responsiveness to a thymus‐independent antigen early after adult thymectomy: Evidence for short‐lived inhibitory thymus‐derived cells

1972 • 132 citations

Requirement for Cross-Linkage in the Stimulation of Transformation of Rabbit Peripheral Lymphocytes by Antiglobulin Reagents

1970 • 131 citations

Enhancement of the antibody response to type 3 pneumococcal polysaccharide in mice treated with antilymphocyte serum.

1970 • 130 citations

Inhibition of secondary anti‐hapten responses with the hapten conjugated to type 3 pneumococcal polysaccharide

1972 • 128 citations

Role of macrophages in in vitro induction of T-helper cells

1975 • 120 citations

MECHANISM OF ACTIVATION OF THE BONE MARROW-DERIVED LYMPHOCYTE

1973 • 111 citations

Molecular Basis of B‐Cell Activation

1974 • 102 citations

EFFECT OF B-CELL MITOGENS ON LYMPHOCYTE SUBPOPULATIONS POSSESSING C'3 AND Fc RECEPTORS

1974 • 97 citations

B cell heterogeneity—Difference in the size of B lymphocytes responding to T dependent and T independent antigens

1975 • 90 citations

Regulation of the Antibody Response to Type III Pneumococcal Polysaccharide

1974 • 86 citations

Enhancement of the Antibody Response to Type III Pneumococcal Polysaccharide in Mice Treated with Antilymphocyte Serum

1970 • 85 citations

Selection of Cell Populations in Induction of Tolerance: Affinity of Antibody Formed in Partially Tolerant Rabbits

1968 • 83 citations

Separate Thymus Dependent and Thymus Independent Antibody Forming Cell Precursors

1971 • 81 citations

B and T-cell stimulatory activities of multiple mitogens from pokeweed

1974 • 71 citations

Antigen Recognition: Early Surface-Receptor Phenomena Induced by Binding of a Tritium-Labeled Antigen

1972 • 68 citations

Regulation of antibody response in vitro. IX. Induction of secondary anti-hapten IgG antibody response by anti-immunoglobulin and enhancing soluble factor.

1975 • 67 citations

Induction of immunity and tolerance in vitro by hapten protein conjugates. II. Carrier independence of the response to dinitrophenylated polymerized flagellin

1972 • 65 citations

Stimulation of human lymphocytes by B-cell mitogens.

1974 • 64 citations

INDUCTION OF B CELL TOLERANCE IN VITRO TO 2,4-DINITROPHENYL COUPLED TO A COPOLYMER OF <scp>D</scp>-GLUTAMIC ACID AND <scp>D</scp>-LYSINE (DNP-<scp>D</scp>-GL)

1973 • 59 citations

Influence of molecular structure on the tolerogenicity of bacterial dextrans. II. The alpha1--3-linked epitope of dextran B1355.

1975 • 57 citations

IMMUNOLOGICAL TOLERANCE IN BONE MARROW-DERIVED LYMPHOCYTES

1974 • 50 citations

Regulation of the Antibody Response to Type III Pneumococcal Polysaccharide

1974 • 49 citations

Failure of Lymphocytes to Reexpress Antigen Receptors after Brief Interaction with a Tolerogenic D-Amino Acid Copolymer

1974 • 43 citations

Mechanisms at the cellular level during induction of high zone tolerance in vitro

1972 • 43 citations

Studies on immunological paralysis. X. Cellular characteristics of the induction and loss of tolerance to levan (Polyfructose).

1972 • 42 citations

Induction of B cell tolerance to polysaccharides by exhaustive immunization and during immunosuppression with cyclophosphamide

1974 • 41 citations

Role of epitope density in the induction of immunity and tolerance with thymus‐independent antigens. II. Studies with 2,4‐dinitrophenyl conjugates in vivo

1975 • 41 citations

Induction of primary and inhibition of secondary antibody response to hapten by hapten conjugates of type III pneumococcal polysaccharide

1975 • 37 citations

Tolerance Induction by an Apparently Non-immunogenic Molecule

1970 • 34 citations

T–T interaction in the generation of helper cells in vitro

1975 • 30 citations

Lack of requirement for cell cooperation in the antibody response to DNP conjugated to levan

1975 • 29 citations

Molecular size and structure in relation to the tolerogenicity of small fructosans (levans)

1976 • 21 citations

Immunogenicity In Vitro: Structural Correlation

1974 • 20 citations

Influence of molecular structure of the tolerogenicity of bacterial dextrans. III. Dissociation between tolerance and immunity to the alpha1--6- and alpha1--3-linked epitopes of dextran B1355.

1975 • 18 citations

Relative Affinity and Avidity of the Antigen-binding Receptors of T and B Rosette-forming Cells

1973 • 15 citations

The response of mice to type III pneumococcal polysaccharide: Failure to detect thymus-derived suppressor cells

1975 • 11 citations

Comparison of in vitro immunogenicity, tolerogenicity and mitogenicity of dinitrophenyl-levan conjugates with varying epitope density.

1976 • 11 citations

Immunological tolerance

1975 • 9 citations

THREE CATEGORIES OF B CELL TOLERANCE INDUCED BY POLYSACCHARIDES: CHARACTERISTICS, INTERRELATIONSHIPS AND GENERAL IMPLICATIONS

1974 • 5 citations

B CELL TOLERANCE INDUCED BY NON-METABOLIZED OR TOXIC ANTIGENS

1974 • 1 citations