Role of Glutathione S-Transferases in Protection against Lipid Peroxidation

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Free radicals in biology and medicine

1991 • 17,840 citations

Glutathione S-Transferases

1974 • 17,321 citations

Improved method for the determination of blood glutathione.

1963 • 6,733 citations

A SPECTROPHOTOMETRIC METHOD FOR MEASURING THE BREAKDOWN OF HYDROGEN PEROXIDE BY CATALASE

1952 • 6,430 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

The MAPK signaling cascade

1995 • 3,300 citations

[59] Glutathione reductase

1985 • 2,854 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Glutathione Transferases—Structure and Catalytic Activit

1988 • 1,751 citations

Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

1985 • 1,081 citations

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase

1985 • 961 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides

1982 • 779 citations

HEMOGLOBIN CATABOLISM

1957 • 774 citations

The Glutathione S ‐Transferases: A Group of Multifunctional Detoxification Proteins

1978 • 686 citations

Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation

1999 • 578 citations

Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI.

1993 • 550 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway

1999 • 539 citations

Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides.

1990 • 516 citations

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

1999 • 516 citations

Zeta, a novel class of glutathione transferases in a range of species from plants to humans

1997 • 498 citations

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

1999 • 485 citations

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1996 • 457 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

[18] Determination of superoxide dismutase activity by purely chemical system based on NAD(P)H oOxidation

1990 • 449 citations

Purification and characterization of human plasma glutathione peroxidase: A selenoglycoprotein distinct from the known cellular enzyme

1987 • 415 citations

Human glutathione transferase A4-4: an Alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation

1998 • 372 citations

Doxorubicin-induced Apoptosis in Endothelial Cells and Cardiomyocytes Is Ameliorated by Nitrone Spin Traps and Ebselen

2000 • 368 citations

Glutathione peroxidase activity of glutathione-S-transferases purified from rat liver

1977 • 360 citations

Human Glutathione S-Transferases

1998 • 353 citations

Sequential protein kinase reactions controlling cell growth and differentiation

1994 • 342 citations

Glutathione Transferases As Markers Of Preneoplasia And Neoplasia

1989 • 308 citations

Glutathione S-transferase class Kappa: characterization by the cloning of rat mitochondrial GST and identification of a human homologue

1996 • 298 citations

Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Suppresses Apoptosis Mediated by a Mitochondrial Death Pathway

1999 • 285 citations

Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases.

2000 • 263 citations

Cytochrome c release and caspase activation in hydrogen peroxide‐ and tributyltin‐induced apoptosis

1998 • 254 citations

Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera

1997 • 231 citations

Role of Peroxiredoxins in Regulating Intracellular Hydrogen Peroxide and Hydrogen Peroxide-induced Apoptosis in Thyroid Cells

2000 • 221 citations

4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death

2000 • 215 citations

Interrelationship between anionic and cationic forms of glutathione S-transferases of human liver

1980 • 215 citations

Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity

1999 • 194 citations

Oxidative Stress Induces DNA Fragmentation and Caspase Activation Via the c-Jun NH2-terminal Kinase Pathway in H9c2 Cardiac Muscle Cells

1998 • 193 citations

Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation

1999 • 170 citations

Implication of mitochondria-derived reactive oxygen species, cytochrome C and caspase-3 in N-(4-Hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells

1999 • 147 citations

Role of glutathione S-transferases in oxidative stress–induced male germ cell apoptosis

2000 • 135 citations

Inhibition of microsomal lipid peroxidation by glutathione and glutathione transferases B and AA. Role of endogenous phospholipase A2

1984 • 128 citations

Gamma-glutamylcysteine synthetase. Interactions of an essential sulfhydryl group.

1984 • 127 citations

The Role of Human Glutathione S-Transferases hGSTA1-1 and hGSTA2-2 in Protection against Oxidative Stress

1999 • 126 citations

Effects of mGST A4 Transfection on 4-Hydroxynonenal-Mediated Apoptosis and Differentiation of K562 Human Erythroleukemia Cells

1999 • 124 citations

Oxidized LDLs alter the activity of the ubiquitin‐proteasome pathway: potential role in oxidized LDL‐induced apoptosis

2000 • 121 citations

Estimation of genomic complexity, heterologous expression, and enzymatic characterization of mouse glutathione S-transferase mGSTA4-4 (GST 5.7).

1994 • 118 citations

Selective Activation of the c-Jun N-Terminal Protein Kinase Pathway during 4-Hydroxynonenal-Induced Apoptosis of PC12 Cells

2000 • 117 citations

Glutathione S-transferases of human lung: Characterization and evaluation of the protective role of the α-class isozymes against lipid peroxidation

1992 • 117 citations

Involvement of Hydrogen Peroxide in Topoisomerase Inhibitor β-lapachone-Induced Apoptosis and Differentiation in Human Leukemia Cells

1998 • 106 citations

Several Closely Related Glutathione S-Transferase Isozymes Catalyzing Conjugation of 4-Hydroxynonenal Are Differentially Expressed in Human Tissues

1994 • 105 citations

Activation of Caspase 3 in HL-60 Cells Exposed to Hydrogen Peroxide

1999 • 95 citations

Myeloperoxidase Is Involved in H2O2-induced Apoptosis of HL-60 Human Leukemia Cells

2000 • 90 citations

Generation of hydrogen peroxide precedes loss of mitochondrial membrane potential during DNA alkylation‐induced apoptosis

1999 • 90 citations

Cloning and heterologous expression of cDNA encoding class Alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic α,β-unsaturated carbonyl compounds

1992 • 86 citations

Involvement of c-JunNH₂-Terminal Kinase Activation and c-Junin the Induction of Apoptosis by the Ether Phospholipid 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine

1998 • 85 citations

Characterization of the hydroperoxide-reducing activity of human plasma

1987 • 73 citations

Lipid photooxidation in erythrocyte ghosts: Sensitization of the membranes toward ascorbate- and superoxide-induced peroxidation and lysis

1985 • 70 citations

Reversal of typical multidrug resistance by cyclosporin and its non-immunosuppressive analogue SDZ PSC 833 in Chinese hamster ovary cells expressing themdr1 phenotype

1992 • 66 citations

4‐Hydroxynonenal Induces Oxidative Stress and Death of Cultured Spinal Cord Neurons

2000 • 65 citations

Death signaling pathway induced by pyrrolidine dithiocarbamate-Cu2+ complex in the cultured rat cortical astrocytes

2000 • 57 citations

ATP-Dependent Human Erythrocyte Glutathione-Conjugate Transporter. I. Purification, Photoaffinity Labeling, and Kinetic Characteristics of ATPase Activity^†

1998 • 39 citations

Identification of a Novel Human GlutathioneS-Transferase Using Bioinformatics

1998 • 34 citations

Different effects of Triton X-100, deoxycholate, and fatty acids on the kinetics of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase

1986 • 34 citations

1 Phospholipid Hydroperoxide Peroxidase Activities in Erythrocytes

1997 • 7 citations

Induction of apoptosis of monocyte‐macrophage lineage cells by 5‐S‐GAD

1999 • 6 citations

Deleted Work

1955 • 0 citations