α-Helix stability in proteins

Empirical Predictions of Protein Conformation

1978 • 3,167 citations

DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.

1987 • 2,266 citations

[14]Determination and analysis of urea and guanidine hydrochloride denaturation curves

1986 • 2,265 citations

Solvation energy in protein folding and binding

1986 • 1,853 citations

Theory of the Phase Transition between Helix and Random Coil in Polypeptide Chains

1959 • 1,756 citations

Database of homology‐derived protein structures and the structural meaning of sequence alignment

1991 • 1,641 citations

Amino Acid Preferences for Specific Locations at the Ends of α Helices

1988 • 1,356 citations

Environment and exposure to solvent of protein atoms. Lysozyme and insulin

1973 • 1,259 citations

A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids

1990 • 1,173 citations

The nature of the accessible and buried surfaces in proteins

1976 • 1,151 citations

Hydrogen bonding and biological specificity analysed by protein engineering

1985 • 1,050 citations

Specific Intermediates in the Folding Reactions of Small Proteins and the Mechanism of Protein Folding

1982 • 1,041 citations

The α-helix dipole and the properties of proteins

1978 • 985 citations

Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design.

1987 • 930 citations

Interior and surface of monomeric proteins

1987 • 924 citations

Hydrophobic bonding and accessible surface area in proteins

1974 • 887 citations

On the Theory of Helix—Coil Transition in Polypeptides

1961 • 785 citations

Conformation of amino acid side-chains in proteins

1978 • 777 citations

Unusually stable helix formation in short alanine-based peptides.

1989 • 752 citations

Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding.

1987 • 738 citations

Accessible surface areas as a measure of the thermodynamic parameters of hydration of peptides.

1987 • 737 citations

Theory of hydrophobic bonding. II. Correlation of hydrocarbon solubility in water with solvent cavity surface area

1972 • 694 citations

Helix Signals in Proteins

1988 • 648 citations

The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)

1984 • 563 citations

The role of the α-helix dipole in protein function and structure

1985 • 517 citations

Reconciling the Magnitude of the Microscopic and Macroscopic Hydrophobic Effects

1991 • 509 citations

The hydrogen bond in molecular recognition

1987 • 462 citations

Relative helix-forming tendencies of nonpolar amino acids

1990 • 455 citations

Side Chain Contributions to the Stability of Alpha-Helical Structure in Peptides

1990 • 455 citations

Accurate simulation of protein dynamics in solution.

1988 • 442 citations

Extracting hydrophobic free energies from experimental data: relationship to protein folding and theoretical models

1991 • 431 citations

Strength and co-operativity of contributions of surface salt bridges to protein stability

1990 • 415 citations

Contribution of hydrophobic interactions to protein stability

1988 • 413 citations

The folding of an enzyme

1992 • 376 citations

Induction of peptide conformation at apolar water interfaces. 1. A study with model peptides of defined hydrophobic periodicity

1985 • 374 citations

Capping and α-helix stability

1989 • 363 citations

α-Helix stability in proteins

1992 • 361 citations

Molecular dynamics of native protein

1983 • 358 citations

Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles

1990 • 350 citations

Energetics of complementary side chain packing in a protein hydrophobic core

1989 • 346 citations

5′–3′ Exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesis

1988 • 336 citations

Aromatic-aromatic interactions and protein stability

1991 • 321 citations

Large differences in the helix propensities of alanine and glycine

1991 • 307 citations

Enhanced protein thermostability from designed mutations that interact with α-helix dipoles

1988 • 290 citations

Empirical Correlation Between Hydrophobic Free Energy and Aqueous Cavity Surface Area

1974 • 284 citations

Selective Inactivation of the Exonuclease Activity of Bacteriophage T7 DNA Polymerase by in Vitro Mutagenesis

1989 • 258 citations

Theory of protein secondary structure and algorithm of its prediction

1983 • 241 citations

Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis

1991 • 238 citations

Effect of active site residues in barnase on activity and stability

1992 • 231 citations

Stabilization of protein structure by interaction of α-helix dipole with a charged side chain

1988 • 229 citations

Molecular structure of a new family of ribonucleases

1982 • 222 citations

The folding of an enzyme

1992 • 216 citations

Histidine-aromatic interactions in barnase

1992 • 210 citations

Effect of alanine versus glycine in α-helices on protein stability

1992 • 198 citations

Molecular dynamics of native protein

1983 • 190 citations

Helix‐coil stability constants for the naturally occurring amino acids in water. XXIV. Half‐cystine parameters from random poly(hydroxybutylglutamine‐<scp>CO</scp>‐S‐methylthio‐<scp>L</scp>‐cysteine)

1990 • 172 citations

The folding of an enzyme

1992 • 172 citations

Surface electrostatic interactions contribute little to stability of barnase

1991 • 168 citations

Analysis of the interaction between charged side chains and the .alpha.-helix dipole using designed thermostable mutants of phage T4 lysozyme

1991 • 164 citations

Helix-coil stability constants for the naturally occurring amino acids in water. 22. Histidine parameters from random poly[(hydroxybutyl)glutamine-co-L-histidine]

1984 • 162 citations

Determination of the three-dimensional solution structure of barnase using nuclear magnetic resonance spectroscopy

1991 • 122 citations

Histidine residues at the N- and C-termini of .alpha.-helixes: perturbed pKas and protein stability

1992 • 122 citations

The helical s constant for alanine in water derived from template-nucleated helices

1991 • 119 citations

Stabilization of λ repressor against thermal denaturation by site‐directed Gly→Ala changes in α‐helix 3

1986 • 115 citations

Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59

1992 • 107 citations

Thermodynamic group contributions from ion pair extraction equilibriums for use in the prediction of partition coefficients. Correlation of surface area with group contributions

1973 • 106 citations

An N-terminal fragment of barnase has residual helical structure similar to that in a refolding intermediate

1992 • 92 citations

Crystal structure of a Barnase-d(GpC) complex at 1.9 Å resolution

1991 • 90 citations

Physical reasons for secondary structure stability: α‐Helices in short peptides

1991 • 87 citations

Straight-chain non-polar amino acids are good helix-formers in water

1991 • 82 citations

Recurring loop motif in proteins that occurs in right-handed and left-handed forms

1988 • 73 citations

Expression of Bacillus amyloliquefaciens extracellular ribonuclease (barnase) in Escherichia coli following an inactivating mutation

1987 • 67 citations

Positional independence and additivity of amino acid replacements on helix stability in monomeric peptides

1990 • 59 citations

Helix‐coil stability constants for the naturally occurring amino acids in water. XII. Asparagine parameters from random poly(hydroxybutylglutamine‐co‐<scp>L</scp>‐asparagine)

1977 • 57 citations

Effect of the substitution Ala .fwdarw. Gly at each of five residue positions in the C-peptide helix

1989 • 55 citations

Contributions of left-handed helical residues to the structure and stability of bacteriophage T4 lysozyme

1989 • 54 citations

Proline for alanine substitutions in the C-peptide helix of ribonuclease A

1991 • 47 citations

COSMIC analysis of the major α-helix of barnase during folding

1991 • 42 citations

Helix‐coil stability constants for the naturally occurring amino acids in water. XXIII. Proline parameters from random poly(hydroxybutylglutamine‐<scp>CO</scp>‐<scp>L</scp>‐proline)

1990 • 36 citations

Helix formation in apocytochrome b5: the role of a neutral histidine at the N-cap position

1991 • 36 citations

Characterization of phosphate binding in the active site of barnase by site-directed mutagenesis and NMR

1991 • 32 citations

Local effect of glycine substitution in a model helical peptide

1991 • 32 citations

On α-helices terminated by glycine

1991 • 32 citations

Two-state conformational transition of the extracellular ribonuclease of Bacillus amyloliquefaciens (barnase) induced by sodium dodecyl sulfate

1975 • 31 citations

Solvents, Interfaces and Protein Structure

1978 • 24 citations

Three‐dimensional structure of ribonuclease from Bacillus intermedius 7P at 3.2 Å resolution

1983 • 23 citations

A violent birth for Mercury

1988 • 22 citations

Position effect on apparent helical propensities in the C-peptide helix

1991 • 22 citations

Accessible surface areas as a measure of the thermodynamic parameters of hydration of peptides

1987 • 14 citations

Position effect on apparent helical propensities in the C-peptide helix

1991 • 4 citations