A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids

Some Factors in the Interpretation of Protein Denaturation

1959 • 4,817 citations

Computed circular dichroism spectra for the evaluation of protein conformation

1969 • 3,654 citations

Spectroscopic Determination of Tryptophan and Tyrosine in Proteins^*

1967 • 3,423 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

[14]Determination and analysis of urea and guanidine hydrochloride denaturation curves

1986 • 2,265 citations

Conformational parameters for amino acids in helical, β-sheet, and random coil regions calculated from proteins

1974 • 2,173 citations

Determination of the helix and β form of proteins in aqueous solution by circular dichroism

1974 • 2,040 citations

Theory of the Phase Transition between Helix and Random Coil in Polypeptide Chains

1959 • 1,756 citations

Amino Acid Preferences for Specific Locations at the Ends of α Helices

1988 • 1,356 citations

Protein stability curves

1987 • 990 citations

Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design.

1987 • 930 citations

Structural characterization of folding intermediates in cytochrome c by H-exchange labelling and proton NMR

1988 • 823 citations

Conformation of amino acid side-chains in proteins

1978 • 777 citations

α‐Helical coiled coils and bundles: How to design an α‐helical protein

1990 • 720 citations

NMR evidence for an early framework intermediate on the folding pathway of ribonuclease A

1988 • 583 citations

Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions

1990 • 485 citations

Preferential Heterodimer Formation by Isolated Leucine Zippers from Fos and Jun

1989 • 469 citations

Protein Design, a Minimalist Approach

1989 • 465 citations

Relative helix-forming tendencies of nonpolar amino acids

1990 • 455 citations

Side Chain Contributions to the Stability of Alpha-Helical Structure in Peptides

1990 • 455 citations

Analysis of the relationship between side-chain conformation and secondary structure in globular proteins

1987 • 422 citations

Conformational stability of globular proteins

1990 • 390 citations

Induction of peptide conformation at apolar water interfaces. 1. A study with model peptides of defined hydrophobic periodicity

1985 • 374 citations

Capping and α-helix stability

1989 • 363 citations

Energetics of complementary side chain packing in a protein hydrophobic core

1989 • 346 citations

THE THERMODYNAMIC STABILITY OF PROTEINS

1987 • 338 citations

The Stereochemistry of Peptides Containing α-Aminoisobutyric Aci

1984 • 335 citations

Enzymatic activity of a synthetic 99 residue protein corresponding to the putative HIV-1 protease

1988 • 234 citations

Unfolding free energy changes determined by the linear extrapolation method. 2. Incorporation of .DELTA.G.degree.N-U values in a thermodynamic cycle

1988 • 203 citations

Equilibrium dissociation and unfolding of the arc repressor dimer

1989 • 202 citations

Synthetic model for two-stranded alpha-helical coiled-coils. Design, synthesis, and characterization of an 86-residue analog of tropomyosin.

1981 • 179 citations

Helix‐coil stability constants for the naturally occurring amino acids in water. XXIV. Half‐cystine parameters from random poly(hydroxybutylglutamine‐<scp>CO</scp>‐S‐methylthio‐<scp>L</scp>‐cysteine)

1990 • 172 citations

Secondary structure predictions and medium range interactions

1987 • 163 citations

Helix-coil stability constants for the naturally occurring amino acids in water. 22. Histidine parameters from random poly[(hydroxybutyl)glutamine-co-L-histidine]

1984 • 162 citations

Structural and functional role of leucine residues in proteins

1973 • 135 citations

Proline‐induced constraints in α‐helices

1987 • 127 citations

Stabilization of λ repressor against thermal denaturation by site‐directed Gly→Ala changes in α‐helix 3

1986 • 115 citations

Side‐chain interactions in the C‐peptide helix: Phe 8 ⃛ His 12⁺

1990 • 106 citations

Use of random copolymers to determine the helix-coil stability constants of the naturally occurring amino acids

1978 • 99 citations

A mutant T4 lysozyme (Val 131 → Ala) designed to increase thermostability by the reduction of strain within an α‐helix

1990 • 83 citations

Macromolecular characterization by sedimentation equilibrium in the preparative ultracentrifuge.

1979 • 79 citations

Conformationally constrained α‐helical peptide models for protein ion channels

1990 • 75 citations

Structural Studies of Mutants of T4 Lysozyme That Alter Hydrophobic Stabilization

1989 • 67 citations

Recent Excitement in Understanding Transfer RNA Identity

1988 • 61 citations

Positional independence and additivity of amino acid replacements on helix stability in monomeric peptides

1990 • 59 citations

The role of ion pairs in .alpha. helix stability: two new designed helical peptides

1989 • 53 citations

Helix–coil transition theory including long‐range electrostatic interactions: Application to globular proteins

1987 • 51 citations

Conformational constraints of amino acid side chains in α‐helices

1987 • 50 citations

Helix‐coil stability constants for the naturally occurring amino acids in water. XXIII. Proline parameters from random poly(hydroxybutylglutamine‐<scp>CO</scp>‐<scp>L</scp>‐proline)

1990 • 36 citations

Kinetic circular dichroism shows that the S-peptide alpha-helix of ribonuclease S unfolds fast and refolds slowly.

1984 • 33 citations

Measurement of the refolding combination reaction between S-peptide and S-protein

1983 • 20 citations

Amide proton exchange used to monitor the formation of a stable α-helix by residues 3 to 13 during folding of ribonuclease S

1984 • 17 citations

The RaMPS system: simplified peptide synthesis for life science researchers.

1989 • 15 citations