Side Chain Contributions to the Stability of Alpha-Helical Structure in Peptides

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Computed circular dichroism spectra for the evaluation of protein conformation

1969 • 3,654 citations

Prediction of protein conformation

1974 • 3,327 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

Conformational parameters for amino acids in helical, β-sheet, and random coil regions calculated from proteins

1974 • 2,173 citations

A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules

1980 • 1,886 citations

Theory of the Phase Transition between Helix and Random Coil in Polypeptide Chains

1959 • 1,756 citations

Amino Acid Preferences for Specific Locations at the Ends of α Helices

1988 • 1,356 citations

A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids

1990 • 1,173 citations

Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design.

1987 • 930 citations

Assignment of complex proton NMR spectra via two-dimensional homonuclear Hartmann-Hahn spectroscopy

1985 • 814 citations

Unusually stable helix formation in short alanine-based peptides.

1989 • 752 citations

Ion-pairs in proteins

1983 • 687 citations

Conformational preferences of amino acids in globular proteins

1978 • 653 citations

Helix Signals in Proteins

1988 • 648 citations

Tests of the helix dipole model for stabilization of α-helices

1987 • 598 citations

Further developments of protein secondary structure prediction using information theory

1987 • 573 citations

The role of the α-helix dipole in protein function and structure

1985 • 517 citations

Relative helix-forming tendencies of nonpolar amino acids

1990 • 455 citations

Analysis of the relationship between side-chain conformation and secondary structure in globular proteins

1987 • 422 citations

Two-Point Calibration of Circular Dichrometer with d-10-Camphorsulfonic Acid

1977 • 390 citations

Capping and α-helix stability

1989 • 363 citations

Nature of the charged-group effect on the stability of the C-peptide helix.

1985 • 313 citations

Design of a 4-helix bundle protein: synthesis of peptides which self-associate into a helical protein

1987 • 282 citations

Persistence of the .alpha.-helix stop signal in the S-peptide in trifluoroethanol solutions

1989 • 212 citations

A helix stop signal in the isolated S-peptide of ribonuclease A

1984 • 189 citations

Derivative spectroscopy applied to tyrosyl chromophores. Ribonuclease, lima bean inhibitors, insulin, and pancreatic trypsin inhibitor

1973 • 167 citations

Helix-coil stability constants for the naturally occurring amino acids in water. 22. Histidine parameters from random poly[(hydroxybutyl)glutamine-co-L-histidine]

1984 • 162 citations

Structural and functional role of leucine residues in proteins

1973 • 135 citations

α-Proton chemical shifts and secondary structure in proteins

1989 • 131 citations

Proline‐induced constraints in α‐helices

1987 • 127 citations

Use of random copolymers to determine the helix-coil stability constants of the naturally occurring amino acids

1978 • 99 citations

A mutant T4 lysozyme (Val 131 → Ala) designed to increase thermostability by the reduction of strain within an α‐helix

1990 • 83 citations

Ion pairs in alpha helices

1987 • 62 citations

Thermodynamic parameters of helix–coil transition in polypeptide chains. II. Poly‐<scp>L</scp>‐lysine

1971 • 61 citations

Positional independence and additivity of amino acid replacements on helix stability in monomeric peptides

1990 • 59 citations

Effect of the substitution Ala .fwdarw. Gly at each of five residue positions in the C-peptide helix

1989 • 55 citations

The role of ion pairs in .alpha. helix stability: two new designed helical peptides

1989 • 53 citations

Conformational constraints of amino acid side chains in α‐helices

1987 • 50 citations

Analysis of peptides for helical prediction

1989 • 36 citations