Characterization of the active site of human multicatalytic proteinase

Statistical estimations in enzyme kinetics

1961 • 3,586 citations

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1982 • 1,024 citations

A linear equation that describes the steady-state kinetics of enzymes and subcellular particles interacting with tightly bound inhibitors

1972 • 524 citations

Mapping the active site of papain with the aid of peptide substrates and inhibitors

1970 • 410 citations

Evidence that Pituitary Cation‐Sensitive Neutral Endopeptidase Is a Multicatalytic Protease Complex

1983 • 356 citations

Determination of the rate constant of enzyme modification by measuring the substrate reaction in the presence of the modifier

1982 • 341 citations

A high molecular weight protease in the cytosol of rat liver. I. Purification, enzymological properties, and tissue distribution.

1986 • 327 citations

Mammalian Proteases : A Glossary and Bibliography

1986 • 299 citations

Inhibition of serine proteases by peptidyl fluoromethyl ketones

1986 • 242 citations

Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor

1985 • 231 citations

Purification and characterization of a multicatalytic high-molecular-mass proteinase from rat skeletal muscle

1985 • 208 citations

Low-Molecular-Weight Enzyme Inhibitors of Microbial Origin

1982 • 206 citations

The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B

1988 • 139 citations

Affinity purification and biochemical characterization of histolysin, the major cysteine proteinase of Entamoeba histolytica

1988 • 134 citations

The Slow, Tight‐Binding Inhibition of Cathepsin B by Leupeptin

1982 • 93 citations

Proteinase Inhibitors

2021 • 73 citations

Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B.

1987 • 72 citations

Inhibition of cathepsin B by peptidyl aldehydes and ketones: slow-binding behavior of a trifluoromethyl ketone

1988 • 45 citations

Negatively Charged Reactants as Probes in the Study of the Essential Mercaptide‐Imidazolium Ion‐Pair of Thiolenzymes

1977 • 31 citations

A high-molecular-mass neutral endopeptidase-24.5 from human lung

1987 • 28 citations