Microinjection of ubiquitin: changes in protein degradation in HeLa cells subjected to heat-shock.

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay

1973 • 3,279 citations

The induction of gene activity in drosophila by heat shock

1979 • 1,308 citations

Heat shock, from bacteria to man

1982 • 1,260 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

The Heat Shock Respons

1985 • 809 citations

Mechanisms of Intracellular Protein Breakdown

1982 • 647 citations

Identification and characterization of multiple forms of actin

1976 • 530 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

Production of abnormal proteins in E. coli stimulates transcription of ion and other heat shock genes

1985 • 521 citations

hsp70: Nuclear concentration during environmental stress and cytoplasmic storage during recovery

1984 • 400 citations

Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides

1980 • 395 citations

Ubiquitin is a heat shock protein in chicken embryo fibroblasts.

1985 • 392 citations

Evidence that Pituitary Cation‐Sensitive Neutral Endopeptidase Is a Multicatalytic Protease Complex

1983 • 356 citations

Genetic control of heat-shock protein synthesis and its bearing on growth and thermal resistance in Escherichia coli K-12.

1982 • 322 citations

Cell Surface Molecule Associated with Lymphocyte Homing Is a Ubiquitinated Branched-Chain Glycoprotein

1986 • 312 citations

An Ancient Developmental Induction: Heat-Shock Proteins Induced in Sporulation and Oogenesis

1986 • 294 citations

Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins.

1982 • 293 citations

Changes in Eukaryotic Gene Expression in Response to Environmental Stress

1985 • 289 citations

Functional heterogeneity of ubiquitin carrier proteins.

1985 • 281 citations

Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.

1986 • 278 citations

Intracellular Protein Catabolism

1996 • 259 citations

The ubiquitin‐mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation

1984 • 221 citations

lon gene product of Escherichia coli is a heat-shock protein

1984 • 221 citations

Heat shock regulatory gene htpR influences rates of protein degradation and expression of the lon gene in Escherichia coli.

1984 • 217 citations

Purification and characterization of a multicatalytic high-molecular-mass proteinase from rat skeletal muscle

1985 • 208 citations

Identification and quantitation of levels of protein synthesis initiation factors in crude HeLa cell lysates by two-dimensional polyacrylamide gel electrophoresis.

1983 • 193 citations

Metabolism of ubiquitinated histones.

1981 • 193 citations

Use of peptide tagging to detect proteins expressed from cloned genes: deletion mapping functional domains of Drosophila hsp 70.

1984 • 175 citations

A transient thermotolerant survival response produced by single thermal doses in HeLa cells.

1976 • 174 citations

A gene regulating the heat shock response in Escherichia coli also affects proteolysis.

1984 • 171 citations

Molecular genetics: What turns on heat shock genes?

1985 • 171 citations

Expression Cloning of a Lymphocyte Homing Receptor cDNA: Ubiquitin Is the Reactive Species

1986 • 163 citations

Molecular and Cellular Effects of Heat-shock and Related Treatments of Mammalian Tissue-culture Cells

1982 • 154 citations

Conjugation of ubiquitin to denatured hemoglobin is proportional to the rate of hemoglobin degradation in HeLa cells.

1982 • 128 citations

Degradation of proteins microinjected into IMR-90 human diploid fibroblasts.

1981 • 121 citations

Actin gene mutations in Drosophila ; heat shock activation in the indirect flight muscles

1985 • 116 citations

Ubiquitin ? protein conjugates

1981 • 113 citations

Ubiquitin-lysozyme conjugates. Purification and susceptibility to proteolysis.

1986 • 108 citations

Ubiquitin Is a Heat Shock Protein in Chicken Embryo Fibroblasts

1985 • 105 citations

Purification of neutral lens endopeptidase: close similarity to a neutral proteinase in pituitary.

1985 • 93 citations

The Pattern of Protein Synthesis Induced by Heat Shock of HeLa Cells

1981 • 89 citations

Small heat shock proteins of Drosophila associate with the cytoskeleton.

1986 • 88 citations

Investigation of adenylate energy charge, phosphorylation potential, and ATP concentration in cells stressed with starvation and heat

1985 • 69 citations

Microinjection of ubiquitin: intracellular distribution and metabolism in HeLa cells maintained under normal physiological conditions.

1987 • 64 citations

Intracellular distribution and degradation of immunoglobulin G and immunoglobulin G fragments injected into HeLa cells.

1983 • 55 citations

[23] Ubiquitination of Proteins

1984 • 40 citations

Intracellular Localization and Possible Functions of Heat Shock Proteins

1985 • 31 citations

Formation of conjugates by ¹²⁵I‐labelled ubiquitin microinjected into cultured hepatoma cells

1982 • 25 citations

Degradation rates and intracellular distributions of structurally characterized proteins injected into HeLa cells.

1985 • 5 citations