Chemokines in Immunity

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Chemokines

2000 • 3,773 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Analysis of Fractalkine Receptor CX₃CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

2000 • 2,356 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

1994 • 2,251 citations

Human Chemokines: An Update

1997 • 2,235 citations

CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease

1999 • 2,174 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1996 • 1,973 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Chemokines

1997 • 1,926 citations

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

1999 • 1,760 citations

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1998 • 1,687 citations

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

1996 • 1,678 citations

lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines

1993 • 1,650 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

Rheumatoid Arthritis

1990 • 1,565 citations

Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response

1997 • 1,536 citations

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1998 • 1,535 citations

A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

1996 • 1,482 citations

Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites

1998 • 1,448 citations

The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

1997 • 1,414 citations

Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion

1997 • 1,406 citations

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

1998 • 1,382 citations

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

2000 • 1,379 citations

The Molecular Biology of Leukocyte Chemoattractant Receptors

1994 • 1,224 citations

A chemokine-driven positive feedback loop organizes lymphoid follicles

2000 • 1,220 citations

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 • 1,209 citations

Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.

1996 • 1,196 citations

Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation

1998 • 1,190 citations

Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

2000 • 1,188 citations

A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

1996 • 1,125 citations

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

1997 • 1,124 citations

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

1997 • 1,078 citations

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

1997 • 1,073 citations

Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor.

1988 • 1,039 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization

1999 • 1,030 citations

Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions

1998 • 1,013 citations

A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes

1998 • 1,001 citations

Molecular cloning of gene sequences regulated by platelet-derived growth factor

1983 • 989 citations

Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines.

1987 • 983 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

Interferon–inducible T Cell Alpha Chemoattractant (I-TAC): A Novel Non-ELR CXC Chemokine with Potent Activity on Activated T Cells through Selective High Affinity Binding to CXCR3

1998 • 857 citations

CCR5⁺and CXCR3⁺T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions

1999 • 839 citations

The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells

1999 • 839 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1

2000 • 820 citations

Molecular cloning and structure of a pre-B-cell growth-stimulating factor.

1994 • 818 citations

A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1

1998 • 810 citations

B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5

1998 • 807 citations

Mig and IP-10: CXC chemokines that target lymphocytes

1997 • 802 citations

P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues

1997 • 735 citations

Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins

1993 • 722 citations

The chemokine system: redundancy for robust outputs

1999 • 716 citations

Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine

1999 • 710 citations

Distinct patterns and kinetics of chemokine production regulate dendritic cell function

1999 • 692 citations

The Chemokine Receptor CXCR4 Is Required for the Retention of B Lineage and Granulocytic Precursors within the Bone Marrow Microenvironment

1999 • 691 citations

Lymphocyte Trafficking and Regional Immunity

1999 • 686 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow

1998 • 679 citations

Lymphotactin: a Cytokine that Represents a New Class of Chemokine

1994 • 668 citations

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

1997 • 656 citations

A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo

2000 • 643 citations

Structure and Chromosomal Localization of the Human Stromal Cell-Derived Factor 1 (SDF1) Gene

1995 • 629 citations

Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties.

1998 • 627 citations

Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.

1996 • 626 citations

Cutting Edge: Secondary Lymphoid-Tissue Chemokine (SLC) and CC Chemokine Receptor 7 (CCR7) Participate in the Emigration Pathway of Mature Dendritic Cells from the Skin to Regional Lymph Nodes

1999 • 621 citations

Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment

2000 • 620 citations

Human monocyte chemoattractant protein‐1 (MCP‐1) Full‐length cDNA cloning, expression in mitogen‐stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE

1989 • 593 citations

Localization of Distinct Peyer's Patch Dendritic Cell Subsets and Their Recruitment by Chemokines Macrophage Inflammatory Protein (Mip)-3α, Mip-3β, and Secondary Lymphoid Organ Chemokine

2000 • 578 citations

Cloning, expression, and characterization of the human eosinophil eotaxin receptor.

1996 • 561 citations

Lymphotoxin α/β and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen

1999 • 552 citations

The T Cell-directed CC Chemokine TARC Is a Highly Specific Biological Ligand for CC Chemokine Receptor 4

1997 • 550 citations

CC chemokines in allergic inflammation

1994 • 540 citations

High endothelial venules (HEVs): specialized endothelium for lymphocyte migration

1995 • 539 citations

Up-Regulation of Macrophage Inflammatory Protein-3α/CCL20 and CC Chemokine Receptor 6 in Psoriasis

2000 • 533 citations

A dendritic-cell-derived C–C chemokine that preferentially attracts naive T cells

1997 • 532 citations

Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes

1987 • 513 citations

Chemoattractant signaling and leukocyte activation

1995 • 510 citations

Transforming Growth Factor β1, in the Presence of Granulocyte/Macrophage Colony-stimulating Factor and Interleukin 4, Induces Differentiation of Human Peripheral Blood Monocytes into Dendritic Langerhans Cells

1998 • 507 citations

Cellular Interactions in Thymocyte Development

1996 • 503 citations

CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells

1999 • 502 citations

The anatomical basis of intestinal immunity

1997 • 493 citations

Human G Protein–Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed Chemokine–Mediated Chemotaxis

1999 • 492 citations

High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

1997 • 489 citations

Cutting Edge: Differential Regulation of Chemokine Receptors During Dendritic Cell Maturation: A Model for Their Trafficking Properties

1998 • 486 citations

Human Macrophage–derived Chemokine (MDC), a Novel Chemoattractant for Monocytes, Monocyte-derived Dendritic Cells, and Natural Killer Cells

1997 • 486 citations

CCR6 Mediates Dendritic Cell Localization, Lymphocyte Homeostasis, and Immune Responses in Mucosal Tissue

2000 • 485 citations

In Vivo–Activated Cd4 T Cells Upregulate Cxc Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines

1999 • 482 citations

A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells

1996 • 479 citations

Epstein-Barr Virus–induced Molecule 1 Ligand Chemokine Is Expressed by Dendritic Cells in Lymphoid Tissues and Strongly Attracts Naive T Cells and Activated B Cells

1998 • 479 citations

Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.

1997 • 474 citations

Early T Lymphocyte Progenitors

1996 • 473 citations

ANTIGEN SAMPLING ACROSS EPITHELIAL BARRIERS AND INDUCTION OF MUCOSAL IMMUNE RESPONSES

1996 • 462 citations

Impaired Host Defense, Hematopoiesis, Granulomatous Inflammation and Type 1–Type 2 Cytokine Balance in Mice Lacking CC Chemokine Receptor 1

1997 • 454 citations

Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1β, and MIP-1α

1996 • 454 citations

BLC Expression in Pancreatic Islets Causes B Cell Recruitment and Lymphotoxin-Dependent Lymphoid Neogenesis

2000 • 450 citations

Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells.

1998 • 450 citations

Recent Advances in Chemokines and Chemokine Receptors

1999 • 414 citations

Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC

1997 • 413 citations

Molecular Cloning of Human Eotaxin, an Eosinophil-selective CC Chemokine, and Identification of a Specific Eosinophil Eotaxin Receptor, CC Chemokine Receptor 3

1996 • 412 citations

The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells.

1998 • 409 citations

Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific Functional Ligand for EBI1, CCR7

1997 • 405 citations

CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha.

1999 • 404 citations

Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis–like lesions

1999 • 401 citations

Contrasting Effects of CCR5 and CCR2 Deficiency in the Pulmonary Inflammatory Response to Influenza A Virus

2000 • 388 citations

Macrophage Inflammatory Protein 3α Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors

2000 • 377 citations

EBI1/CCR7 Is a New Member of Dendritic Cell Chemokine Receptor That Is Up-Regulated upon Maturation

1998 • 377 citations

Macrophage-derived Chemokine Is a Functional Ligand for the CC Chemokine Receptor 4

1998 • 376 citations

Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells

1999 • 367 citations

CCR6, a CC Chemokine Receptor that Interacts with Macrophage Inflammatory Protein 3α and Is Highly Expressed in Human Dendritic Cells

1997 • 362 citations

CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1

1998 • 358 citations

The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9

2000 • 358 citations

Molecular Cloning of a Novel Human CC Chemokine Liver and Activation-regulated Chemokine (LARC) Expressed in Liver

1997 • 354 citations

CC-Chemokine Receptor 6 Is Expressed on Diverse Memory Subsets of T Cells and Determines Responsiveness to Macrophage Inflammatory Protein 3α

1999 • 345 citations

A Th2 Chemokine, TARC, Produced by Keratinocytes May Recruit CLA+CCR4+ Lymphocytes into Lesional Atopic Dermatitis Skin

2000 • 342 citations

Cutting Edge: The Chemokine Receptor CCR8 Is Preferentially Expressed in Th2 But Not Th1 Cells

1998 • 341 citations

Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization

1998 • 340 citations

6-C-kine (SLC), a Lymphocyte Adhesion-triggering Chemokine Expressed by High Endothelium, Is an Agonist for the MIP-3β Receptor CCR7

1998 • 331 citations

Cutting Edge: The Orphan Chemokine Receptor G Protein-Coupled Receptor-2 (GPR-2, CCR10) Binds the Skin-Associated Chemokine CCL27 (CTACK/ALP/ILC)

2000 • 327 citations

Secondary Lymphoid-tissue Chemokine Is a Functional Ligand for the CC Chemokine Receptor CCR7

1998 • 325 citations

Stromal Cell-derived Factor-1α Associates with Heparan Sulfates through the First β-Strand of the Chemokine

1999 • 322 citations

Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta.

1997 • 318 citations

Amino acid sequence of human platelet factor 4.

1977 • 318 citations

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

1996 • 316 citations

Chemokine Up-Regulation and Activated T Cell Attraction by Maturing Dendritic Cells

1999 • 315 citations

The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7

1998 • 311 citations

Cutting Edge: A Novel Chemokine Ligand for CCR10 And CCR3 Expressed by Epithelial Cells in Mucosal Tissues

2000 • 310 citations

Cc Chemokine Receptor (Ccr)3/Eotaxin Is Followed by Ccr4/Monocyte-Derived Chemokine in Mediating Pulmonary T Helper Lymphocyte Type 2 Recruitment after Serial Antigen Challenge in Vivo

2000 • 309 citations

T helper 1 and T helper 2 cells respond differentially to chemokines.

1998 • 309 citations

Molecular Cloning of a Novel T Cell-directed CC Chemokine Expressed in Thymus by Signal Sequence Trap Using Epstein-Barr Virus Vector

1996 • 304 citations

The Role of Chemokines in the Microenvironmental Control of T versus B Cell Arrest in Peyer's Patch High Endothelial Venules

2000 • 298 citations

Active movement of T cells away from a chemokine

2000 • 293 citations

TECK: A Novel CC Chemokine Specifically Expressed by Thymic Dendritic Cells and Potentially Involved in T Cell Development

1997 • 292 citations

Regulation of Human Chemokine Receptors CXCR4

1997 • 290 citations

Cloning and Characterization of a Specific Receptor for the Novel CC Chemokine MIP-3α from Lung Dendritic Cells

1997 • 289 citations

Identification of a Novel Chemokine (CCL28), which Binds CCR10 (GPR2)

2000 • 285 citations

Inducible Expression of a Th2-Type CC Chemokine Thymus- and Activation-Regulated Chemokine by Human Bronchial Epithelial Cells

2000 • 285 citations

IP-10 Is Critical for Effector T Cell Trafficking and Host Survival in Toxoplasma gondii Infection

2000 • 283 citations

STCP-1 (MDC) CC Chemokine Acts Specifically on Chronically Activated Th2 Lymphocytes and Is Produced by Monocytes on Stimulation with Th2 Cytokines IL-4 and IL-13

1998 • 275 citations

A Key Role for Cc Chemokine Receptor 4 in Lipopolysaccharide-Induced Endotoxic Shock

2000 • 275 citations

Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5–Positive Cd4 Cells and Germinal Centers

1999 • 275 citations

Regulation of dendritic cell trafficking: a process that involves the participation of selective chemokines

1999 • 275 citations

Macrophage Inflammatory Protein 3α Is Involved in the Constitutive Trafficking of Epidermal Langerhans Cells

1999 • 272 citations

Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules.

1993 • 271 citations

Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice

2001 • 267 citations

Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)

1989 • 266 citations

Molecular Cloning of a Novel Human CC Chemokine Secondary Lymphoid-Tissue Chemokine That Is a Potent Chemoattractant for Lymphocytes and Mapped to Chromosome 9p13

1997 • 260 citations

Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells

1994 • 260 citations

Trafficking of the HIV Coreceptor CXCR4

1999 • 258 citations

Mouse Monocyte-Derived Chemokine Is Involved in Airway Hyperreactivity and Lung Inflammation

1999 • 256 citations

A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes.

1997 • 256 citations

Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern.

1998 • 253 citations

Mice with a Selective Deletion of the CC Chemokine Receptors 5 or 2 Are Protected from Dextran Sodium Sulfate-Mediated Colitis: Lack of CC Chemokine Receptor 5 Expression Results in a NK1.1+ Lymphocyte-Associated Th2-Type Immune Response in the Intestine

2000 • 253 citations

Fractalkine Is an Epithelial and Endothelial Cell-Derived Chemoattractant for Intraepithelial Lymphocytes in the Small Intestinal Mucosa

2000 • 252 citations

Impaired Macrophage Function and Enhanced T Cell-Dependent Immune Response in Mice Lacking CCR5, the Mouse Homologue of the Major HIV-1 Coreceptor

1998 • 252 citations

The CC chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3 beta are potent chemoattractants for in vitro- and in vivo-derived dendritic cells.

1999 • 251 citations

"The good, the bad, and the ugly." The role of chemokines in models of human disease.

1996 • 250 citations

The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3

1998 • 249 citations

Cutting Edge: Developmental Switches in Chemokine Responses During T Cell Maturation

1999 • 247 citations

Transendothelial Migration of Megakaryocytes in Response to Stromal Cell-derived Factor 1 (SDF-1) Enhances Platelet Formation

1998 • 244 citations

Molecular Uncoupling of Fractalkine-mediated Cell Adhesion and Signal Transduction

1999 • 242 citations

Cutting Edge: T Helper 1 and T Helper 2 Cells Respond Differentially to Chemokines

1998 • 238 citations

Identification of CCR8: A Human Monocyte and Thymus Receptor for the CC Chemokine I-309

1997 • 237 citations

A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution

1999 • 233 citations

CX3C-Chemokine, Fractalkine-Enhanced Adhesion of THP-1 Cells to Endothelial Cells Through Integrin-Dependent and -Independent Mechanisms

2000 • 227 citations

β Chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production

1996 • 227 citations

Molecular cloning and functional characterization of human lymphotactin.

1995 • 223 citations

Developmental Switches in Chemokine Response Profiles during B Cell Differentiation and Maturation

2000 • 222 citations

The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes

1999 • 217 citations

Combined chemokine and cytokine gene transfer enhances antitumor immunity

1996 • 215 citations

Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells

1994 • 214 citations

Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans

1999 • 207 citations

Divergent Effects of Interleukin-4 and Interferon-γ on Macrophage-Derived Chemokine Production: An Amplification Circuit of Polarized T Helper 2 Responses

1998 • 203 citations

Secondary Lymphoid Tissue Chemokine Mediates T Cell-Dependent Antitumor Responses In Vivo

2000 • 202 citations

Selective recruitment of polarized T cells expressing CCR5 and CXCR3 to the inflamed joints of children with juvenile idiopathic arthritis

2000 • 201 citations

Novel lymphocyte-specific CC chemokines and their receptors

1997 • 199 citations

Identification of CCR8, the Receptor for the Human CC Chemokine I-309

1997 • 198 citations

C‐C chemokines, but not the C‐X‐C chemokines interleukin‐8 and interferon‐γ inducible protein‐10, stimulate transendothelial chemotaxis of T lymphocytes

1995 • 197 citations

Fractalkine-Mediated Endothelial Cell Injury by NK Cells

2000 • 194 citations

Sophisticated strategies for information encounter in the lymph node: the reticular network as a conduit of soluble information and a highway for cell traffic.

1996 • 192 citations

Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3α/CCL20 by epidermal keratinocytes and its role in atopic dermatitis

2001 • 188 citations

Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lymphohematopoietic progenitors

1999 • 188 citations

Cutting Edge: Ectopic Expression of the Chemokine TCA4/SLC Is Sufficient to Trigger Lymphoid Neogenesis

2000 • 187 citations

Serial Analysis of Gene Expression in Human Monocyte-Derived Dendritic Cells

1999 • 183 citations

Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords.

1995 • 183 citations

Differential expression of the chemokine receptors by the Th1- and Th2-type effect or populations within circulating CD4+ T cells

2000 • 182 citations

The Role of CCR7 in T _H 1 and T _H 2 Cell Localization and Delivery of B Cell Help in Vivo

1999 • 181 citations

Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.

1983 • 181 citations

Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo

1999 • 179 citations

Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium

1994 • 178 citations

Cloning and Characterization of Exodus, a Novel β-Chemokine

1997 • 176 citations

Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK.

1999 • 175 citations

Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation

1999 • 174 citations

IL-4 induces functional cell-surface expression of CXCR4 on human T cells.

1998 • 169 citations

Expression of monocyte chemoattractant protein‐1 and interleukin‐8 receptors on subsets of T cells: correlation with transendothelial chemotactic potential

1996 • 169 citations

Differential Chemotactic Behavior of Developing T Cells in Response to Thymic Chemokines

1998 • 169 citations

Cutting Edge: Role of C-C Chemokine Receptor 5 in Organ-Specific and Innate Immunity toCryptococcus neoformans

1999 • 168 citations

Cutting Edge: Identification of the Orphan Chemokine Receptor GPR-9-6 as CCR9, the Receptor for the Chemokine TECK

1999 • 167 citations

Identification of Single C Motif-1/Lymphotactin Receptor XCR1

1998 • 167 citations

Identification and characterization of a novel beta chemokine containing six conserved cysteines.

1997 • 166 citations

Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice.

1999 • 163 citations

Antitumor Effects of the Mouse Chemokine 6Ckine/SLC Through Angiostatic and Immunological Mechanisms

2000 • 156 citations

Activated Murine B Lymphocytes and Dendritic Cells Produce a Novel CC Chemokine which Acts Selectively on Activated T Cells

1998 • 151 citations

Lymphotoxin‐α‐deficient and TNF receptor‐I‐deficient mice define developmental and functional characteristics of germinal centers

1997 • 149 citations

A pertussis toxin‐sensitive process controls thymocyte emigration

1991 • 147 citations

Differentiation‐specific expression of a novel G protein‐coupled receptor from Burkitt's lymphoma

1992 • 147 citations

Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice.

1998 • 145 citations

Th1/Th2 subsets: distinct differences in homing and chemokine receptor expression?

1999 • 145 citations

Selective accumulation of CCR5+ T lymphocytes into inflamed joints of rheumatoid arthritis

1999 • 143 citations

Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension.

1997 • 142 citations

Genetic defect in T lymphocyte‐specific homing into peripheral lymph nodes

1997 • 138 citations

A Highly Selective Cc Chemokine Receptor (Ccr)8 Antagonist Encoded by the Poxvirus Molluscum Contagiosum

2000 • 138 citations

A lymphocyte-specific CC chemokine, secondary lymphoid tissue chemokine (SLC), is a highly efficient chemoattractant for B cells and activated T cells

1998 • 137 citations

Monocyte Chemotactic Protein-2 Activates CCR5 and Blocks CD4/CCR5-mediated HIV-1 Entry/Replication

1998 • 137 citations

The murine β-chemokine TARC is expressed by subsets of dendritic cells and attracts primed CD4+ T cells

1999 • 136 citations

CXCR4 and CCR5 on Human Thymocytes: Biological Function and Role in HIV-1 Infection

1998 • 135 citations

Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog

1998 • 134 citations

Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow.

1998 • 133 citations

Secondary Lymphoid-Tissue Chemokine (SLC) Is Chemotactic for Mature Dendritic Cells

1999 • 132 citations

Defects in the Generation of IFN-γ Are Overcome to Control Infection withLeishmania donovaniin CC Chemokine Receptor (CCR) 5-, Macrophage Inflammatory Protein-1α-, or CCR2-Deficient Mice

1999 • 131 citations

CD34+ cell-derived CD14+ precursor cells develop into Langerhans cells in a TGF-beta 1-dependent manner.

1999 • 126 citations

Pertussis Toxin-Sensitive Signal Controls the Trafficking of Thymocytes Across the Corticomedullary Junction in the Thymus

1999 • 123 citations

A cDNA Clone Used to Study mRNA Inducible in Human Tonsillar Lymphocytes by a Tumor Promoter1

1986 • 122 citations

Expression and Cellular Localization of the CC Chemokines PARC and ELC in Human Atherosclerotic Plaques

1999 • 121 citations

Selective Diapedesis of Th1 Cells Induced by Endothelial Cell RANTES

1999 • 118 citations

Secondary Lymphoid-Tissue Chemokine (SLC) Stimulates Integrin α4β7-Mediated Adhesion of Lymphocytes to Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) Under Flow

1998 • 118 citations

Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells.

1997 • 118 citations

Regulator of G Protein Signaling 1 (RGS1) Markedly Impairs Giα Signaling Responses of B Lymphocytes

2000 • 118 citations

Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases

1996 • 116 citations

CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells.

1998 • 115 citations

Lymphotactin Gene-Modified Bone Marrow Dendritic Cells Act as More Potent Adjuvants for Peptide Delivery to Induce Specific Antitumor Immunity

1998 • 114 citations

Macrophage-derived chemokine production by activated human T cellsin vitro andin vivo: preferential association with the production of type 2 cytokines

2000 • 111 citations

Identification of the CC chemokines TARC and macrophage inflammatory protein-1β as novel functional ligands for the CCR8 receptor

1998 • 110 citations

Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells

1999 • 109 citations

CD30 Overexpression Enhances Negative Selection in the Thymus and Mediates Programmed Cell Death Via a Bcl-2-Sensitive Pathway

1999 • 109 citations

Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.

1999 • 104 citations

Macrophage-Derived Chemokine Is Localized to Thymic Medullary Epithelial Cells and Is a Chemoattractant for CD3+, CD4+, CD8low Thymocytes

1999 • 103 citations

Molecular Cloning and Functional Characterization of a Novel CC Chemokine, Stimulated T Cell Chemotactic Protein (STCP-1) That Specifically Acts on Activated T Lymphocytes

1997 • 102 citations

EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC

1998 • 100 citations

STRL22 Is a Receptor for the CC Chemokine MIP-3α

1997 • 97 citations

Factors Regulating Stem Cell Recruitment to the Fetal Thymus

1999 • 97 citations

The Role of CD26/DPP IV in Chemokine Processing

1999 • 95 citations

Alpha(1,3)-fucosyltransferase VII-dependent synthesis of P- and E-selectin ligands on cultured T lymphoblasts.

1998 • 94 citations

Molecular cloning of a novel C or γ type chemokine, SCM‐1

1995 • 92 citations

Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3.

1998 • 91 citations

Transforming Growth Factor-β1 Polarizes Murine Hematopoietic Progenitor Cells to Generate Langerhans Cell-Like Dendritic Cells Through a Monocyte/Macrophage Differentiation Pathway

1999 • 89 citations

Cutting Edge: Immature Dendritic Cells Generated from Monocytes in the Presence of TGF-β1 Express Functional C-C Chemokine Receptor 6

1999 • 89 citations

Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function.

1996 • 88 citations

CCR5 Has an Expanded Ligand-Binding Repertoire and Is the Primary Receptor Used by MCP-2 on Activated T Cells

1998 • 87 citations

TECK, an Efficacious Chemoattractant for Human Thymocytes, Uses GPR-9-6/CCR9 as a Specific Receptor

1999 • 86 citations

The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and Expressed Sequence Tag Databases

1997 • 86 citations

Cloning of ATAC, an activation‐induced, chemokine‐related molecule exclusively expressed in CD8+ T lymphocytes

1995 • 84 citations

A High Endothelial Cell-Derived Chemokine Induces Rapid, Efficient, and Subset-Selective Arrest of Rolling T Lymphocytes on a Reconstituted Endothelial Substrate

1998 • 83 citations

Structure and function of the glycosaminoglycan binding site of chemokine macrophage-inflammatory protein-1 beta.

1999 • 82 citations

Cutting Edge: Identification of the Orphan Receptor G-Protein-Coupled Receptor 2 as CCR10, a Specific Receptor for the Chemokine ESkine

2000 • 82 citations

Eotaxin Activates T Cells to Chemotaxis and Adhesion Only if Induced to Express CCR3 by IL-2 Together with IL-4

1999 • 80 citations

CXC chemokine modulation of angiogenesis: the importance of balance between angiogenic and angiostatic members of the family.

1998 • 80 citations

Chemotactic Response Toward Chemokines and Its Regulation by Transforming Growth Factor-β1 of Murine Bone Marrow Hematopoietic Progenitor Cell-Derived Different Subset of Dendritic Cells

1999 • 79 citations

Role of Gut Cryptopatches in Early Extrathymic Maturation of Intestinal Intraepithelial T Cells

2000 • 75 citations

Cutting Edge: Species Specificity of the CC Chemokine 6Ckine Signaling Through the CXC Chemokine Receptor CXCR3: Human 6Ckine Is Not A Ligand for the Human or Mouse CXCR3 Receptors

1999 • 74 citations

A migratory population of skin-derived dendritic cells expresses CXCR5, responds to B lymphocyte chemoattractantin vitro, and co-localizes to B cell zones in lymph nodesin vivo

2000 • 73 citations

Positive and Negative Thymocyte Selection

1998 • 72 citations

CC Chemokine Receptors, CCR-1 and CCR-3, Are Potentially Involved in Antigen-Presenting Cell Function of Human Peripheral Blood Monocyte-Derived Dendritic Cells

1999 • 71 citations

Macrophage-Derived Chemokine and EBI1-Ligand Chemokine Attract Human Thymocytes in Different Stage of Development and Are Produced by Distinct Subsets of Medullary Epithelial Cells: Possible Implications for Negative Selection

2000 • 70 citations

Role of the C Terminus of the Interleukin 8 Receptor in Signal Transduction and Internalization

1996 • 69 citations

Upregulation of Integrin 6/β1 and Chemokine Receptor CCR1 by Interleukin-12 Promotes the Migration of Human Type 1 Helper T Cells

1999 • 66 citations

A weighting system and aigorithm for aligning many phylogenetically related sequences

1995 • 65 citations

Structure and expression of two highly related genes encoding SCM‐1/human lymphotactin

1996 • 65 citations

Molecular cloning of a novel CC chemokine, interleukin‐11 receptor α‐locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus

1999 • 59 citations

Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13<footref rid="foot01"><sup>1</sup></footref>

1998 • 56 citations

A New Monoclonal Antibody, mAb 4A12, Identifies a Role for the Glycosaminoglycan (GAG) Binding Domain of RANTES in the Antiviral Effect against HIV-1 and Intracellular Ca2+ Signaling

1998 • 52 citations

Detection and delineation of CXCR-4 (fusin) as an entry and fusion cofactor for T-tropic [correction of T cell-tropic] HIV-1 by three different monoclonal antibodies.

1998 • 51 citations

Chemokine PARC Gene (SCYA18) Generated by Fusion of Two MIP-1α/LD78α-like Genes

1999 • 47 citations

Molecular cloning of mXCR1, the murine SCM‐1/lymphotactin receptor

1999 • 45 citations

ESkine, a Novel β-Chemokine, Is Differentially Spliced to Produce Secretable and Nuclear Targeted Isoforms

1999 • 44 citations

Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation

1999 • 44 citations

Chemokine receptors and their role in leukocyte activation

1999 • 43 citations

Assignment of the Human CC Chemokine Gene TARC (SCYA17) to Chromosome 16q13

1997 • 41 citations

Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine “mini-cluster”

1996 • 40 citations

The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1β are not ligands for human CC-chemokine receptor 8

1999 • 39 citations

Detection and Delineation of CXCR-4 (Fusin) as an Entry and Fusion Cofactor for T Cell-Tropic HIV-1 by Three Different Monoclonal Antibodies

1998 • 38 citations

Organization of the Chemokine Gene Cluster on Human Chromosome 17q11.2 Containing the Genes for CC Chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES

1999 • 37 citations

Coevolution of the mammalian chemokines and their receptors

1999 • 34 citations

The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4+ T cells

2000 • 34 citations

Chemokine Homolog of Molluscum Contagiosum Virus: Sequence Conservation and Expression

1998 • 32 citations

Chemokines Fail to Up-Regulate β1 Integrin-Dependent Adhesion in Human Th2 T Lymphocytes

2000 • 29 citations

Isolation of ALP, a Novel Divergent Murine CC Chemokine with a Unique Carboxy Terminal Extension

1999 • 25 citations

Assignment of the Human CC Chemokine MPIF-2/Eotaxin-2 (SCYA24) to Chromosome 7q11.23

1998 • 24 citations

Genomic Organization of the Genes for Human and Mouse CC Chemokine LEC

1999 • 16 citations

The Human CC Chemokine TECK (SCYA25) Maps to Chromosome 19p13.2

1998 • 10 citations

Deleted Work

1955 • 0 citations