Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice.

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Chemokines — Chemotactic Cytokines That Mediate Inflammation

1998 • 3,660 citations

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

1996 • 3,106 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1996 • 2,502 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

1997 • 1,078 citations

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

1997 • 1,073 citations

Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.

1994 • 711 citations

Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine

1999 • 710 citations

Molecular Cloning and Functional Expression of a New Human CC-Chemokine Receptor Gene

1996 • 701 citations

Defects in Macrophage Recruitment and Host Defense in Mice Lacking the CCR2 Chemokine Receptor

1997 • 700 citations

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2

1997 • 671 citations

Chemokine receptors: Gateways to inflammation and infection

1996 • 659 citations

Requirement of Mip-1α for an Inflammatory Response to Viral Infection

1995 • 636 citations

Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1β, and MIP-1α

1996 • 454 citations

Impaired Host Defense, Hematopoiesis, Granulomatous Inflammation and Type 1–Type 2 Cytokine Balance in Mice Lacking CC Chemokine Receptor 1

1997 • 454 citations

Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells.

1998 • 450 citations

Differential CC chemokine-induced enhancement of T helper cell cytokine production.

1997 • 417 citations

The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells.

1998 • 409 citations

Chemokines and T Lymphocytes

1998 • 403 citations

Early Murine Cytomegalovirus (MCMV) Infection Induces Liver Natural Killer (NK) Cell Inflammation and Protection Through Macrophage Inflammatory Protein 1α (MIP-1α)–dependent Pathways

1998 • 375 citations

Chemokines: signal lamps for trafficking of T and B cells for development and effector function

1999 • 348 citations

MIP-1α and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphoctye differentiation

1997 • 312 citations

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1α, MIP-1β, and RANTES

1996 • 301 citations

Chemokines and Chemokine Receptors: Biology and Clinical Relevance in Inflammation and AIDS

1999 • 293 citations

Impaired Macrophage Function and Enhanced T Cell-Dependent Immune Response in Mice Lacking CCR5, the Mouse Homologue of the Major HIV-1 Coreceptor

1998 • 252 citations

Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production.

1996 • 251 citations

"The good, the bad, and the ugly." The role of chemokines in models of human disease.

1996 • 250 citations

Synthesis of the CC-chemokines MIP-1alpha, MIP-1beta, and RANTES is associated with a type 1 immune response.

1996 • 244 citations

Experimental visceral leishmaniasis: production of interleukin 2 and interferon-gamma, tissue immune reaction, and response to treatment with interleukin 2 and interferon-gamma.

1987 • 199 citations

Experimental visceral leishmaniasis: role of endogenous IFN-gamma in host defense and tissue granulomatous response.

1989 • 176 citations

Monocyte Chemoattractant Protein-3 Is a Functional Ligand for CC Chemokine Receptors 1 and 2B

1995 • 171 citations

Cutting Edge: Role of C-C Chemokine Receptor 5 in Organ-Specific and Innate Immunity toCryptococcus neoformans

1999 • 168 citations

Dendritic Cell (DC)-Based Anti-Infective Strategies: DCs Engineered to Secrete IL-12 Are a Potent Vaccine in a Murine Model of an Intracellular Infection

1999 • 140 citations

Monocyte Chemotactic Protein 1 Regulates Oral Tolerance Induction by Inhibition of T Helper Cell 1–related Cytokines

1998 • 138 citations

Absence of Macrophage Inflammatory Protein-1α Prevents the Development of Blinding Herpes Stromal Keratitis

1998 • 123 citations

Regional Differences in the Cellular Immune Response to Experimental Cutaneous or Visceral Infection withLeishmania donovani

1998 • 123 citations

Cellular and molecular mechanisms of IFN-γ production induced by IL-2 and IL-12 in a human NK cell line

1995 • 108 citations

Profile of human T cell response to leishmanial antigens. Analysis by immunoblotting.

1989 • 58 citations