The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4+ T cells

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Human Chemokines: An Update

1997 • 2,235 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Chemokines

1997 • 1,926 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

1997 • 1,073 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

1997 • 656 citations

Glycosaminoglycans Mediate Cell Surface Oligomerization of Chemokines

1997 • 512 citations

Activation of Dual T Cell Signaling Pathways by the Chemokine RANTES

1995 • 463 citations

Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes.

1996 • 443 citations

Interleukin 2 regulates its own receptors.

1985 • 414 citations

Interleukin 2 Regulates Expression of Its Receptor and Synthesis of Gamma Interferon by Human T Lymphocytes

1984 • 350 citations

The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

1998 • 340 citations

Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation in vitro.

1996 • 316 citations

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc

1998 • 298 citations

Chemokine expression by intraepithelial gamma delta T cells. Implications for the recruitment of inflammatory cells to damaged epithelia.

1996 • 250 citations

Molecular cloning and functional characterization of human lymphotactin.

1995 • 223 citations

Combined chemokine and cytokine gene transfer enhances antitumor immunity

1996 • 215 citations

Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway

1997 • 215 citations

Chemokines regulate T cell adherence to recombinant adhesion molecules and extracellular matrix proteins.

1996 • 211 citations

Differential Regulation of HIV-1 Fusion Cofactor Expression by CD28 Costimulation of CD4⁺T Cells

1997 • 206 citations

Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells.

1993 • 203 citations

Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo.

1997 • 191 citations

Transcription Factors in Lymphocyte Development— T and B Cells Get Together

1999 • 169 citations

Identification of Single C Motif-1/Lymphotactin Receptor XCR1

1998 • 167 citations

Alternative Polyadenylation Events Contribute to the Induction of NF-ATc in Effector T Cells

1999 • 160 citations

Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry.

1997 • 160 citations

RANTES induces tyrosine kinase activity of stably complexed p125FAK and ZAP-70 in human T cells.

1996 • 152 citations

A common factor regulates both Th1- and Th2-specific cytokine gene expression.

1994 • 151 citations

Transcription Mediated by NFAT Is Highly Inducible in Effector CD4⁺ T Helper 2 (Th2) Cells but Not in Th1 Cells

1997 • 115 citations

Prolonged IL-2 receptor alpha/CD25 expression after T cell activation via the adhesion molecules CD2 and CD28. Demonstration of combined transcriptional and post-transcriptional regulation.

1992 • 115 citations

Lymphotactin Gene-Modified Bone Marrow Dendritic Cells Act as More Potent Adjuvants for Peptide Delivery to Induce Specific Antitumor Immunity

1998 • 114 citations

Newly discovered role for Fas ligand in the cell-cycle arrest of CD4+ T cells

1998 • 109 citations

RANTES and macrophage inflammatory protein 1 alpha selectively enhance immunoglobulin (IgE) and IgG4 production by human B cells.

1996 • 106 citations

Migratory response of human natural killer cells to lymphotactin

1996 • 106 citations

Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models

1999 • 105 citations

Interferon‐inducible protein‐10 and lymphotactin induce the chemotaxis and mobilization of intracellular calcium in natural killer cells through pertussis toxin‐sensitive and ‐insensitive heterotrimeric G‐proteins

1997 • 105 citations

T-cell subsets: Chemokine receptors guide the way

1998 • 99 citations

Molecular cloning of a novel C or γ type chemokine, SCM‐1

1995 • 92 citations

Thrombopoietin and the Hematopoietic Stem Cell

1998 • 89 citations

I-309/T cell activation gene-3 chemokine protects murine T cell lymphomas against dexamethasone-induced apoptosis.

1996 • 88 citations

Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation.

1997 • 87 citations

Cloning of ATAC, an activation‐induced, chemokine‐related molecule exclusively expressed in CD8+ T lymphocytes

1995 • 84 citations

RANTES stimulation of T lymphocyte adhesion and activation: role for LFA‐1 and ICAM‐3

1997 • 78 citations

The Interleukin 2 Receptor α Chain/CD25 Promoter Is a Target for Nuclear Factor of Activated T Cells

1998 • 77 citations

Intrinsic resistance to T cell infection with HIV type 1 induced by CD28 costimulation.

1997 • 76 citations

Lymphotactin Acts as an Innate Mucosal Adjuvant

1999 • 69 citations

Th2-Specific Protein/DNA Interactions at the Proximal Nuclear Factor-AT Site Contribute to the Functional Activity of the Human IL-4 Promoter

1998 • 68 citations

Lymphotactin gene expression in mast cells following Fc(epsilon) receptor I aggregation: modulation by TGF-beta, IL-4, dexamethasone, and cyclosporin A.

1997 • 66 citations

Purification, Structural Analysis, and Function of Natural ATAC, a Cytokine Secreted by CD8+ T Cells

1997 • 65 citations

CD28 costimulation up-regulates long-term IL-2R beta expression in human T cells through combined transcriptional and post-transcriptional regulation.

1995 • 61 citations

Recruitment of pleckstrin and phosphoinositide 3-kinase gamma into the cell membranes, and their association with G beta gamma after activation of NK cells with chemokines.

1999 • 58 citations

Distinct Regulation of T-Cell Death by CD28 Depending on Both Its Aggregation and T-Cell Receptor Triggering: A Role for Fas-FasL

1998 • 50 citations

Recruitment of Pleckstrin and Phosphoinositide 3-Kinase γ into the Cell Membranes, and Their Association with Gβγ After Activation of NK Cells with Chemokines

1999 • 46 citations

Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway

1999 • 41 citations

Itk, a T cell-specific tyrosine kinase, is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat.

1997 • 36 citations

T cell activation via the CD2 molecule is associated with protein kinase C translocation from the cytosol to the plasma membrane

1989 • 32 citations

Macrophage inflammatory protein-1 alpha rapidly modulates its receptors and inhibits the anti-CD3 mAb-mediated proliferation of T lymphocytes.

1993 • 32 citations

The role of co-stimulation in regulation of chemokine receptor expression and HIV-1 infection in primary T lymphocytes

1998 • 21 citations

MURINE LYMPHOTACTIN: GENE STRUCTURE, POST-TRANSLATIONAL MODIFICATION AND INHIBITION OF EXPRESSION BY CD28 COSTIMULATION

1997 • 21 citations

CD28 co-stimulation results in down-regulation of lymphotactin expression in human CD4+ but not CD8+ T cells via an IL-2-dependent mechanism

1999 • 14 citations