Effects of microtubule stabilization and destabilization on tau immunoreactivity in cultured hippocampal neurons

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Cleavage of structural proteins during the assemble of the head of bacterio-phage T4

1970 • 5,738 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

The distribution of tau in the mammalian central nervous system.

1985 • 1,518 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

1984 • 852 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

Microtubule-Associated Proteins: Their Potential Role in Determining Neuronal Morphology

1988 • 599 citations

A Neuronal Antigen in the Brains of Alzheimer Patients

1986 • 577 citations

Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

1988 • 557 citations

Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease1

1986 • 504 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

1987 • 393 citations

Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases.

1990 • 382 citations

Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

1987 • 348 citations

Straight and paired helical filaments in Alzheimer disease have a common structural unit.

1991 • 310 citations

Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments

1986 • 310 citations

Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

1990 • 298 citations

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1990 • 283 citations

Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids.

1987 • 264 citations

Biochemistry of Altered Brain Proteins in Alzheimer's Disease

1989 • 261 citations

Calcium as sculptor and destroyer of neural circuitry

1992 • 250 citations

The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture

1987 • 195 citations

Neuropil threads of Alzheimer's disease show a marked alteration of the normal cytoskeleton

1991 • 138 citations

Experimental colchicine encephalopathy. I. Induction of neurofibrillary degeneration.

1967 • 138 citations

A role for Na ⁺ ‐dependent Ca ²⁺ extrusion in protection against neuronal excitotoxicity

1989 • 134 citations

Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human cortical neurons

1991 • 112 citations

Hippocampal Neurons Predisposed to Neurofibrillary Tangle Formation Are Enriched in Type II Calcium/Calmodulin-Dependent Protein Kinase

1990 • 112 citations

Aberrant casein kinase II in Alzheimer's disease

1990 • 107 citations

Proteolytic processing of beta-amyloid precursor by calpain I

1990 • 105 citations

Developmental expression, compartmentalization, and possible role in excitotoxicity of a putative NMDA receptor protein in cultured hippocampal neurons

1991 • 99 citations

Tau Epitopes are Incorporated into a Range of Lesions in Alzheimerʼs Disease

1987 • 97 citations

Alz-50 recognizes a phosphorylated epitope of tau protein

1990 • 93 citations

Localization of the Alz-50 epitope in recombinant human microtubule-associated protein tau

1991 • 86 citations

Evidence for the involvement of protein kinase C in neurodegenerative changes in cultured human cortical neurons

1991 • 85 citations

Protein kinase C phosphorylates tau and induces its functional alterations

1987 • 78 citations

Neurofibrillary tangles induced by vincristine and vinblastine sulfate in central and peripheral neurons in vitro

1968 • 66 citations

Immunocytochemical properties of Alzheimer straight filaments

1987 • 65 citations

Mapping of the Alz 50 epitope in microtubule‐associated proteins tau

1990 • 60 citations

Aging-Related Increases in Voltage-Sensitive, Inactivating Calcium Currents in Rat Hippocampus Implications for Mechanisms of Brain Aging and Alzheimer's Disease

1989 • 57 citations

A quantitative study of frontal cortex dendritic microtubules in patients with Alzheimer's disease

1987 • 47 citations

Na+/Ca2+ exchange activity is increased in Alzheimer's disease brain tissues

1991 • 42 citations

Phosphorylation characteristics of the A68 protein in Alzheimer's disease

1990 • 36 citations

Aberrant protein phosphorylation and cytoarchitecture in Alzheimer's disease.

1989 • 19 citations

ATP-induced loss of Alz-50 immunoreactivity with the A68 proteins from Alzheimer brain is mediated by ubiquitin.

1990 • 18 citations

Reduced Proteins in Temporal Cortex in Alzheimer's Disease: An Electrophoretic Study

1985 • 18 citations

Reductions in soluble brain proteins in older subjects with Down's syndrome

1985 • 6 citations