Recent Advances in the Molecular Understanding of Voltage-Gated Ca2+ Channels

Ionic channels of excitable membranes

1985 • 7,199 citations

Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4

1996 • 2,308 citations

Three types of neuronal calcium channel with different calcium agonist sensitivity

1985 • 2,212 citations

Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the α1A-voltage-dependent calcium channel

1997 • 1,571 citations

Primary structure of the receptor for calcium channel blockers from skeletal muscle

1987 • 1,359 citations

Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones.

1987 • 1,290 citations

Ionic channels of excitable membranes

1985 • 1,185 citations

The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel

1996 • 1,164 citations

Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells

1994 • 998 citations

Roles of N-Type and Q-Type Ca ²⁺ Channels in Supporting Hippocampal Synaptic Transmission

1994 • 964 citations

STRUCTURE AND FUNCTION OF VOLTAGE-GATED ION CHANNELS

1995 • 941 citations

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel

1989 • 922 citations

Exocytotic Ca2+ channels in mammalian central neurons

1995 • 920 citations

Primary structure and functional expression from complementary DNA of a brain calcium channel

1991 • 871 citations

Calmodulin supports both inactivation and facilitation of L-type calcium channels

1999 • 868 citations

Calmodulin Is the Ca2+ Sensor for Ca2+-Dependent Inactivation of L-Type Calcium Channels

1999 • 822 citations

Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons

1995 • 819 citations

P-type calcium channels in rat central and peripheral neurons

1992 • 788 citations

Differential Distribution of Three Members of a Gene Family Encoding Low Voltage-Activated (T-Type) Calcium Channels

1999 • 779 citations

Absence Epilepsy in Tottering Mutant Mice Is Associated with Calcium Channel Defects

1996 • 773 citations

Low-Threshold Calcium Currents in Central Nervous System Neurons

1996 • 757 citations

Different types of calcium channels mediate central synaptic transmission

1993 • 743 citations

Molecular characterization of a neuronal low-voltage-activated T-type calcium channel

1998 • 722 citations

Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity

1996 • 701 citations

Calcium channel β-subunit binds to a conserved motif in the I–II cytoplasmic linker of the α1-subunit

1994 • 659 citations

Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons

1993 • 635 citations

Inactivation of Ca channels

1984 • 616 citations

Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

1993 • 614 citations

Immunochemical identification and subcellular distribution of the alpha 1A subunits of brain calcium channels

1995 • 590 citations

Sequence and Expression of mRNAs Encoding the α ₁ and α ₂ Subunits of a DHP-Sensitive Calcium Channel

1988 • 579 citations

Structure and Functional Expression of a Member of the Low Voltage-Activated Calcium Channel Family

1993 • 572 citations

Cloning and Characterization of α1H From Human Heart, a Member of the T-Type Ca ²⁺ Channel Gene Family

1998 • 561 citations

Calcium Entry Leads to Inactivation of Calcium Channel in Paramecium

1978 • 532 citations

Loss-of-function mutations in a calcium-channel α1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness

1998 • 505 citations

Structure and functional expression of α1, α2, and β subunits of a novel human neuronal calcium channel subtype

1992 • 499 citations

Structure and Functional Expression of an ω-Conotoxin-Sensitive Human N-Type Calcium Channel

1992 • 496 citations

An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness

1998 • 493 citations

Ca2+/calmodulin binds to and modulates P/Q-type calcium channels

1999 • 478 citations

Molecular Basis for CA2+ Channel Diversity

1994 • 461 citations

Distinctive biophysical and pharmacological properties of class A (BI) calcium channel α1 subunits

1993 • 431 citations

Splicing of α1A subunit gene generates phenotypic variants of P- and Q-type calcium channels

1999 • 425 citations

Dihydropyridine receptor mutations cause hypokalemic periodic paralysis

1994 • 423 citations

Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.

1992 • 416 citations

Mutation of the Ca2+ Channel β Subunit Gene Cchb4 Is Associated with Ataxia and Seizures in the Lethargic (lh) Mouse

1997 • 399 citations

A gene for familial hemiplegic migraine maps to chromosome 19

1993 • 382 citations

Multiple calcium channel types control glutamatergic synaptic transmission in the hippocampus

1993 • 380 citations

Primary Structure of the β Subunit of the DHP-Sensitive Calcium Channel from Skeletal Muscle

1989 • 371 citations

Subunit interaction sites in voltage-dependent Ca2+ channels: role in channel function

1998 • 366 citations

Localization and functional properties of a rat brain alpha 1A calcium channel reflect similarities to neuronal Q- and P-type channels.

1994 • 366 citations

Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels

1997 • 342 citations

Calcium channel beta subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain.

1992 • 339 citations

Calcium domains associated with individual channels can account for anomalous voltage relations of CA-dependent responses

1984 • 324 citations

Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel.

1992 • 317 citations

A calcium channel mutation causing hypokalemic periodic paralysis

1994 • 310 citations

Primary structure of a calcium channel that is highly expressed in the rat cerebellum.

1991 • 309 citations

P-type calcium channels in the somata and dendrites of adult cerebellar purkinje cells

1992 • 308 citations

Familial Infantile Convulsions and Paroxysmal Choreoathetosis: A New Neurological Syndrome Linked to the Pericentromeric Region of Human Chromosome 16

1997 • 299 citations

Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells.

1995 • 294 citations

Ca2+-dependent regulation in neuronal gene expression

1997 • 290 citations

Episodic Ataxia Type 2 (EA2) and Spinocerebellar Ataxia Type 6 (SCA6) Due to CAG Repeat Expansion in the CACNA1A Gene on Chromosome 19p

1997 • 288 citations

Molecular Diversity of the Calcium Channel α₂δ Subunit

1999 • 280 citations

Essential Ca ²⁺ -Binding Motif for Ca ²⁺ -Sensitive Inactivation of L-Type Ca ²⁺ Channels

1995 • 278 citations

Structure and functional characterization of neuronal alpha 1E calcium channel subtypes.

1994 • 278 citations

R-type Ca ²⁺ currents evoke transmitter release at a rat central synapse

1998 • 273 citations

Ca2+ channels: diversity of form and function

1992 • 269 citations

Mechanisms of modulation of voltage‐dependent calcium channels by G proteins

1998 • 269 citations

Structural basis of drug binding to L Ca2+ channels

1998 • 265 citations

Primary Structure of the γ Subunit of the DHP-Sensitive Calcium Channel from Skeletal Muscle

1990 • 263 citations

Functional Consequences of Mutations in the Human α_1ACalcium Channel Subunit Linked to Familial Hemiplegic Migraine

1999 • 257 citations

Ca2+ channel regulation by a conserved β subunit domain

1994 • 252 citations

Stimulus-secretion coupling in pancreatic β cells

1994 • 251 citations

Mechanism of Ca2+-sensitive inactivation of L-type Ca2+ channels

1994 • 245 citations

Mapping of the hypokalaemic periodic paralysis (HypoPP) locus to chromosome 1q31–32 in three European families

1994 • 232 citations

Cloning and expression of a neuronal calcium channel beta subunit

1993 • 228 citations

Molecular determinants of voltage-dependent inactivation in calcium channels

1994 • 217 citations

Familial Hemiplegic Migraine Mutations Change α1ACa2+ Channel Kinetics

1998 • 209 citations

Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis

1991 • 205 citations

Changes in action potential duration alter reliance of excitatory synaptic transmission on multiple types of Ca2+ channels in rat hippocampus

1996 • 199 citations

Calcium-Sensitive Inactivation in the Gating of Single Calcium Channels

1990 • 197 citations

Cloning and expression of a third calcium channel beta subunit.

1993 • 197 citations

Progressive Ataxia Due to a Missense Mutation in a Calcium-Channel Gene

1997 • 191 citations

Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin

1994 • 186 citations

Subunit regulation of the neuronal alpha 1A Ca2+ channel expressed in Xenopus oocytes.

1995 • 183 citations

Ca ²⁺ -sensitive inactivation of L-type Ca ²⁺ channels depends on multiple cytoplasmic amino acid sequences of the α _1C subunit

1998 • 183 citations

Calcium as a modulator of the immediate-early gene cascade in neurons

1988 • 179 citations

The γ-Subunit of Skeletal Muscle Phosphorylase Kinase Contains Two Noncontiguous Domains That Act in Concert to Bind Calmodulin

1989 • 172 citations

Localization of the gene encoding the α₂/δ-subunits of the L-type voltage-dependent calcium channel to chromosome 7q and analysis of the segregation of flanking markers in malignant hyperthermia susceptible families

1994 • 164 citations

The alpha 1E calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels.

1996 • 146 citations

Molecular Structures Involved in L-type Calcium Channel Inactivation

1997 • 144 citations

Whole-Cell and Single-Channel Analysis of P-Type Calcium Currents in Cerebellar Purkinje Cells of Leaner Mutant Mice

1998 • 143 citations

Variable clinical expression of mutations in the P/Q-type calcium channel gene in familial hemiplegic migraine

1998 • 140 citations

Specific Absence of the α1 Subunit of the Dihydropyridine Receptor in Mice with Muscular Dysgenesis

1989 • 137 citations

A novel nonsense mutation in CACNA1A causes episodic ataxia and hemiplegia

1999 • 134 citations

Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice

1997 • 134 citations

The α_1ECalcium Channel Exhibits Permeation Properties Similar to Low-Voltage-Activated Calcium Channels

1996 • 126 citations

The effect of α2‐δ and other accessory subunits on expression and properties of the calcium channel α1G

1999 • 125 citations

A T-type calcium channel from mouse brain

1999 • 124 citations

A single nucleotide deletion in the skeletal muscle-specific calcium channel transcript of muscular dysgenesis (mdg) mice.

1992 • 119 citations

Submicroscopic Ca2+ diffusion mediates inhibitory coupling between individual Ca2+ channels

1992 • 114 citations

Critical roles of the S3 segment and S3-S4 linker of repeat I in activation of L-type calcium channels.

1994 • 114 citations

Calcium currents in bullfrog sympathetic neurons. II. Inactivation.

1989 • 114 citations

SCA6 is caused by moderate CAG expansion in the alpha1A-voltage- dependent calcium channel gene

1997 • 113 citations

Structure and Functional Characterization of a Novel Human Low‐Voltage Activated Calcium Channel

1999 • 111 citations

L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells

1995 • 109 citations

Hypokalemic periodic paralysis and the dihydropyridine receptor (CACNL1A3): genotype/phenotype correlations for two predominant mutations and evidence for the absence of a founder effect in 16 caucasian families.

1995 • 105 citations

Augmentation of cardiac calcium current by flash photolysis of intracellular caged-Ca2+ molecules

1989 • 104 citations

Ca(2+)-dependent inactivation of a cloned cardiac Ca2+ channel alpha 1 subunit (alpha 1C) expressed in Xenopus oocytes

1994 • 99 citations

Migraine, ataxia and epilepsy: a challenging spectrum of genetically determined calcium channelopathies

1998 • 95 citations

Kinetics of calcium‐dependent inactivation of calcium current in voltage‐clamped neurones of Aplysia californica.

1984 • 95 citations

Familial migraine with vertigo: No mutations found in CACNA1A

1998 • 92 citations

Transfer of High Sensitivity for Benzothiazepines from L-type to Class A (BI) Calcium Channels

1996 • 91 citations

Stimulation-dependent facilitation of the high threshold calcium current in guinea-pig ventricular myocytes.

1990 • 90 citations

Structure and alternative splicing of the gene encoding α1I, a human brain T calcium channel α1 subunit

1999 • 90 citations

β Subunit Reshuffling Modifies N- and P/Q-Type Ca2+Channel Subunit Compositions in Lethargic Mouse Brain

1999 • 89 citations

The calcium and frequency dependence of the slow inward current ‘staircase’ in frog atrium.

1981 • 88 citations

Differential Localization of Voltage-Dependent Calcium Channel α₁Subunits at the Human and Rat Neuromuscular Junction

1997 • 83 citations

De novo mutation in CACNA1A caused acetazolamide-responsive episodic ataxia

1998 • 82 citations

Distinctive functional properties of the neuronal BII (class E) calcium channel.

1994 • 82 citations

Known Calcium Channel α1 Subunits Can Form Low Threshold Small Conductance Channels with Similarities to Native T-Type Channels

1998 • 76 citations

Distribution ofα1A, α1B andα1E voltage-dependent calcium channel subunits in the human hippocampus and parahippocampal gyrus

1996 • 72 citations

Calcium inactivation in skeletal muscle fibres of the stick insect, Carausius morosus.

1982 • 69 citations

β subunits influence the biophysical and pharmacological differences between P- and Q-type calcium currents expressed in a mammalian cell line

1997 • 69 citations

The Molecular Basis of Voltage-gated Ca 2+ Channel Diversity: Is It Time for T?

1998 • 68 citations

Calcium channelopathies in the central nervous system

1999 • 64 citations

Familial Hemiplegic Migraine

2006 • 59 citations

Two types of low‐voltage‐activated Ca2+ channels in neurones of rat laterodorsal thalamic nucleus.

1997 • 58 citations

Identification and Cloning of Putative Human Neuronal Voltage-Gated Calcium Channel γ-2 and γ-3 Subunits: Neurologic Implications

1999 • 58 citations

Molecular basis of drug interaction with L-type Ca2+ channels.

1998 • 56 citations

Role of S4 segments and the leucine heptad motif in the activation of an L-type calcium channel

1997 • 55 citations

Molecular diversity of Ca2+ channel β subunits

1994 • 54 citations

Intracellular Ca2+ inactivates L-type Ca2+ channels with a Hill coefficient of approximately 1 and an inhibition constant of approximately 4 microM by reducing channel's open probability

1997 • 53 citations

Properties of Cloned Rat α1A Calcium Channels Transiently Expressed in the COS‐7 Cell Line

1997 • 50 citations

Distribution of the voltage-dependent calcium channel alpha(1A) subunit throughout the mature rat brain and its relationship to neurotransmitter pathways.

1998 • 44 citations

Familial hemiplegic migraine in the Netherlands

1994 • 43 citations

Stable Expression of the Neuronal BI (Class A) Calcium Channel in Baby Hamster Kidney Cells

1994 • 39 citations

Absence of modulation of the expressed calcium channel α1G subunit by α2δ subunits

1999 • 38 citations

Distribution of the voltage-dependent calcium channel ?1A subunit throughout the mature rat brain and its relationship to neurotransmitter pathways

1998 • 37 citations

Ion Channel Mutations in Mouse Models of Inherited Neurological Disease

1997 • 36 citations

The expression of voltage-dependent calcium channel beta subunits in human cerebellum

1997 • 34 citations

Low-voltage activated calcium channels: achievements and problems

1999 • 34 citations

The S5-S6 linker of repeat I is a critical determinant of L-type Ca2+ channel conductance

1997 • 33 citations

Mechanism of Ca 2+ -dependent Inactivation of L-type Ca 2+ Channels in GH 3 Cells: Direct Evidence Against Dephosphorylation by Calcineurin

1997 • 29 citations

Structure and Function of Voltage‐Dependent Calcium Channels from Muscle^a

1993 • 27 citations

Distribution of neurons expressing α1G subunit mRNA of T-type voltage-dependent calcium channel in adult rat central nervous system

1999 • 25 citations

T-type calcium channel in mammalian CNS neurones

1991 • 25 citations

Migraines in Mice?

1996 • 23 citations

Rapid calcium-current kinetics in synaptic terminals of goldfish retinal bipolar neurons

1998 • 23 citations

Molecular biology of neuronal voltage-gated calcium channels

1998 • 14 citations

Divalent cation selectivity of the subtypes of low voltage-activated Ca2+ channels in thalamic neurons

1999 • 10 citations

Genetics and pathology of voltage-gated Ca2+ channels.

1998 • 8 citations

Intra-Cellular Calcium

1994 • 6 citations