Transient Poly(ADP-ribosyl)ation of Nuclear Proteins and Role of Poly(ADP-ribose) Polymerase in the Early Stages of Apoptosis

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis

1997 • 1,233 citations

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1997 • 1,034 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

Development of 3T3‐like lines from Balb/c mouse embryo cultures: Transformation susceptibility to SV40

1968 • 662 citations

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

1996 • 621 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

PARP is important for genomic stability but dispensable in apoptosis

1997 • 556 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

ADP-ribosylation of proteins. Enzymology and biological significance.

1987 • 374 citations

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.

1996 • 351 citations

Calcium-activated DNA Fragmentation in Rat Liver Nuclei

1989 • 281 citations

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1996 • 279 citations

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

1996 • 247 citations

Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.

1995 • 242 citations

Inhibitors of Poly(Adenosine Diphosphate-Ribose) Synthesis: Effect on Other Metabolic Processes

1984 • 241 citations

Monoclonal antibodies to poly(adenosine diphosphate ribose) recognize different structures

1984 • 229 citations

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

1995 • 197 citations

Activation of the CPP32 Apoptotic Protease by Distinct Signaling Pathways with Differential Sensitivity to Bcl-xL

1996 • 190 citations

Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.

1992 • 171 citations

Possible Involvement of Poly(ADP-Ribosyl) Polymerase in Triggering Stress-Induced Apoptosis

1994 • 169 citations

Fas‐mediated apoptosis is modulated by intracellular glutathione in human T cells

1996 • 169 citations

Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways.

1996 • 167 citations

Identification of an Endonuclease Responsible for Apoptosis in Rat Thymocytes

1994 • 160 citations

Resistance to Fas-mediated apoptosis in human hepatoma cells.

1995 • 152 citations

Cleavage of CPP32 by Granzyme B Represents a Critical Role for Granzyme B in the Induction of Target Cell DNA Fragmentation

1996 • 148 citations

Involvement of NAD-poly(ADP-ribose) metabolism in p53 regulation and its consequences.

1995 • 148 citations

Apoptosis and DNA fragmentation precede TNF‐induced cytolysis in U937 cells

1992 • 146 citations

The Expression of Poly(ADP-ribose) Polymerase during Differentiation-Linked DNA Replication Reveals That It Is a Component of the Multiprotein DNA Replication Complex

1996 • 136 citations

ADP-Ribosylation, DNA Repair and Cancer

2020 • 120 citations

Identification of an Endonuclease Responsible for Apoptosis in Rat Thymocytes

1994 • 116 citations

Apoptosis and Its Modulation in Human Promyelocytic HL-60 Cells Treated with DNA Topoisomerase I and II Inhibitors

1993 • 113 citations

Activation of the insulin-like growth factor-I receptor inhibits tumor necrosis factor-induced cell death

1996 • 98 citations

Mechanism of the inhibition of Ca2+, Mg2+-dependent endonuclease of bull seminal plasma induced by ADP-ribosylation.

1984 • 97 citations

Cloning and expression of cDNA for human poly(ADP-ribose) polymerase.

1987 • 97 citations

Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: influences on genomic stability, chromatin organization, and carcinogen cytotoxicity.

1994 • 96 citations

Immunoquantitation and size determination of intrinsic poly(ADP-ribose) polymerase from acid precipitates. An analysis of the in vivo status in mammalian species and in lower eukaryotes.

1988 • 92 citations

Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase

1997 • 89 citations

Intact Cell Evidence for the Early Synthesis, and Subsequent Late Apopain-Mediated Suppression, of Poly(ADP-ribose) during Apoptosis

1997 • 82 citations

Coinduction of c-jun gene expression and internucleosomal DNA fragmentation by ionizing radiation

1993 • 77 citations

Poly(ADP-ribosyl)ation of Histone H1 Correlates with Internucleosomal DNA Fragmentation during Apoptosis

1996 • 72 citations

Inhibitors of poly(ADP‐ribose) polymerase suppress nuclear fragmentation and apoptotic‐body formation during apoptosis in HL‐60 cells

1997 • 61 citations

Requirement for the Expression of Poly(ADP-ribose) Polymerase during the Early Stages of Differentiation of 3T3-L1 Preadipocytes, as Studied by Antisense RNA Induction

1995 • 60 citations

DNA damage, poly (ADP-ribosyl)ation and apoptotic cell death as a potential common pathway of cytotoxic drug action

1991 • 52 citations

The role of poly(ADP-ribose) synthesis in toxicity and repair of DNA damage

1985 • 44 citations

A new approach for the electrophoretic detection of apoptosis

1996 • 40 citations

VP-16-induced nucleotide pool changes and poly(ADP-ribose) synthesis: The role of VP-16 in interphase death

1989 • 37 citations

Engineered Human Skin Model Using Poly(ADP-Ribose) Polymerase Antisense Expression Shows a Reduced Response to DNA Damage

1995 • 30 citations

Effects of 6-aminonicotinamide on cell growth, poly(ADP-ribose) synthesis and nucleotide metabolism

1985 • 29 citations

Poly(ADP-ribose) synthetase and chick limb mesenchymal cell differentiation

1985 • 27 citations

Induction of Apoptosis by the c-Myc Helix-Loop-Helix/Leucine Zipper Domain in Mouse 3T3-L1 Fibroblasts

1995 • 20 citations

Prevention of adriamycin-induced interphase death by 3-aminobenzamide and nicotinamide in a human promyelocytic leukemia cell line

1987 • 19 citations

Qualitative and Quantitative Differences in the Cellular Responses Mediated Through Fas Antigen and Tumor Necrosis Factor Receptor

1996 • 13 citations