Src-Dependence and Pertussis-Toxin Sensitivity of Urokinase Receptor-Dependent Chemotaxis and Cytoskeleton Reorganization in Rat Smooth Muscle Cells

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

1994 • 2,251 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines

1993 • 1,650 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

Antibodies to plasminogen activator inhibit human tumor metastasis

1983 • 651 citations

Identification of the urokinase receptor as an adhesion receptor for vitronectin.

1994 • 593 citations

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

1992 • 571 citations

Chemoattractant signaling and leukocyte activation

1995 • 510 citations

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro.

1995 • 508 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

Migration of smooth muscle and endothelial cells. Critical events in restenosis.

1992 • 406 citations

Prevention of metastasis by inhibition of the urokinase receptor.

1993 • 387 citations

Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes.

1995 • 355 citations

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.

1995 • 324 citations

Smooth muscle migration in atherosclerosis and restenosis.

1997 • 323 citations

Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect.

1996 • 306 citations

The Role of Actin Polymerization in Cell Motility

1991 • 301 citations

Src family protein tyrosine kinases and cellular signal transduction pathways

1995 • 298 citations

Microfilament Structure and Function in the Cortical Cytoskeleton

1991 • 276 citations

Effects of fluid dynamic forces on vascular cell adhesion.

1996 • 263 citations

The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator.

1991 • 256 citations

Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

1994 • 253 citations

Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice.

1996 • 250 citations

Biological Activation of pro-HGF (Hepatocyte Growth Factor) by Urokinase Is Controlled by a Stoichiometric Reaction

1995 • 248 citations

uPA, uPAR, PAI-I: Key intersection of proteolytic, adhesive and chemotacfic highways?

1997 • 246 citations

Requirement of Receptor-bound Urokinase-type Plasminogen Activator for Integrin αvβ5-directed Cell Migration

1996 • 244 citations

A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity

1997 • 236 citations

Relation between cell activity and the distribution of cytoplasmic actin and myosin.

1981 • 236 citations

Association of p60c-src with endosomal membranes in mammalian fibroblasts.

1992 • 233 citations

Generation and characterization of urokinase receptor-deficient mice.

1996 • 232 citations

The Receptor for Urokinase-type Plasminogen Activator Is Not Essential for Mouse Development or Fertility

1995 • 230 citations

Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo.

1994 • 225 citations

Modulation of metastatic potential by cell surface urokinase of murine melanoma cells.

1988 • 223 citations

Urokinase-type plasminogen activator receptors associate with beta1 and beta3 integrins of fibrosarcoma cells: dependence on extracellular matrix components.

1997 • 222 citations

The actin cytoskeleton

1988 • 218 citations

Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy.

1994 • 216 citations

Perspectives series: cell adhesion in vascular biology. Smooth muscle migration in atherosclerosis and restenosis.

1997 • 205 citations

alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor.

1995 • 194 citations

The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin

1993 • 188 citations

Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model.

1996 • 188 citations

Membrane ruffling and signal transduction

1994 • 183 citations

Urokinase‐type plasminogen activator mediates basic fibroblast growth factor‐induced bovine endothelial cell migration independent of its proteolytic activity

1992 • 183 citations

β1 And β3 integrins have different roles in the adhesion and migration of vascular smooth muscle cells on extracellular matrix

1992 • 179 citations

The Jak/Stat Pathway and Urokinase Receptor Signaling in Human Aortic Vascular Smooth Muscle Cells

1998 • 179 citations

Requirement for receptor‐bound urokinase in plasmin‐dependent cellular conversion of latent TGF‐β to TGF‐β

1994 • 176 citations

The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interaction

1997 • 146 citations

Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy?

1994 • 139 citations

Receptor-independent Role of Urokinase-Type Plasminogen Activator in Pericellular Plasmin and Matrix Metalloproteinase Proteolysis during Vascular Wound Healing in Mice

1998 • 132 citations

Immunolocalization of the cellular src protein in interphase and mitotic NIH c-src overexpresser cells.

1990 • 120 citations

Ligand Interaction between Urokinase-Type Plasminogen Activator and Its Receptor Probed with 8-Anilino-1-naphthalenesulfonate. Evidence for a Hydrophobic Binding Site Exposed Only on the Intact Receptor

1994 • 102 citations

Contrasting Effects of Plasminogen Activators, Urokinase Receptor, and LDL Receptor–Related Protein on Smooth Muscle Cell Migration and Invasion

1996 • 100 citations

Mouse L cells expressing human prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion.

1989 • 99 citations

Contrasting roles for integrin beta 1 and beta 5 cytoplasmic domains in subcellular localization, cell proliferation, and cell migration.

1994 • 97 citations

Urokinase and Tissue-type Plasminogen Activator Are Required for the Mitogenic and Chemotactic Effects of Bovine Fibroblast Growth Factor and Platelet-derived Growth Factor-BB for Vascular Smooth Muscle Cells

1997 • 70 citations

Role of Focal Adhesion Proteins in Signal Transduction and Oncogenesis

1997 • 65 citations

A soluble, ligand binding mutant of the human urokinase plasminogen activator receptor

1991 • 65 citations

Urokinase-type plasminogen activator-deficient mice are predisposed to staphylococcal botryomycosis, pleuritis, and effacement of lymphoid follicles.

1997 • 45 citations

Isolation and characterization of multiple isoforms of the rat urokinase receptor in osteoblasts

1994 • 41 citations

Extracellular proteolysis and the migrating vascular smooth muscle cell

1996 • 38 citations

Regulation and function of an activation-dependent epitope of the beta 1 integrins in vascular cells after balloon injury in baboon arteries and in vitro.

1996 • 36 citations