Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

Beyond Cholesterol

1989 • 6,533 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Glutathione metabolism and its selective modification.

1988 • 1,975 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

1987 • 1,152 citations

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

1990 • 871 citations

Transition metals as catalysts of “autoxidation” reactions

1990 • 721 citations

Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions.

1986 • 676 citations

Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages

1990 • 624 citations

Functions of glutathione. Biochemical, physiological, toxicological and clinical aspects

1984 • 595 citations

Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin

1989 • 569 citations

Generation of Superoxide Free Radical during the Autoxidation of Thiols

1974 • 558 citations

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.

1984 • 547 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.

1986 • 516 citations

A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein

1989 • 480 citations

The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.

1987 • 465 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

1989 • 417 citations

Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C

1990 • 321 citations

Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification

1988 • 301 citations

Glutathione deficiency decreases tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects.

1991 • 291 citations

The production of free radicals during the autoxidation of cysteine and their effect on isolated rat hepatocytes

1982 • 283 citations

Mechanisms by which lipoprotein lipase alters cellular metabolism of lipoprotein(a), low density lipoprotein, and nascent lipoproteins. Roles for low density lipoprotein receptors and heparan sulfate proteoglycans.

1992 • 258 citations

Hormone and neurotransmitter receptors in an established vascular endothelial cell line.

1976 • 257 citations

Oxidation of low-density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor

1987 • 236 citations

Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation.

1981 • 230 citations

Role of superoxide in endothelial-cell modification of low-density lipoproteins

1988 • 228 citations

Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification.

1991 • 228 citations

Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages

1991 • 223 citations

Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formation.

1989 • 200 citations

Lipid hydroperoxide involvement in copper-dependent and independent oxidation of low density lipoproteins.

1991 • 177 citations

Fatty streak expansion and maturation in Watanabe Heritable Hyperlipemic and comparably hypercholesterolemic fat-fed rabbits.

1987 • 174 citations

Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages.

1991 • 161 citations

Oxidation of polyunsaturated fatty acids and lipids through thiyl and sulfonyl radicals: Reaction kinetics, and influence of oxygen and structure of thiyl radicals

1992 • 155 citations

Activated human monocytes oxidize low-density lipoprotein by a lipoxygenase-dependent pathway.

1990 • 132 citations

Transport of cystine and cysteine and cell growth in cultured human diploid fibroblasts: Effect of glutamate and homocysteate

1982 • 130 citations

Lipoxygenase-mediated transformation of human low density lipoprotein to an oxidized and cytotoxic complex.

1991 • 123 citations

Mutagenicity of Glutathione and Cysteine in the Ames Test

1983 • 122 citations

Thiyl radical attack on polyunsaturated fatty acids: A possible route to lipid peroxidation

1989 • 110 citations

Cellular oxidative modification of low density lipoprotein does not require lipoxygenases.

1992 • 101 citations

Addition of oxygen to organic sulfur radicals

1978 • 97 citations

Methods for assessment of tissue sites of lipoprotein degradation

1986 • 87 citations

A new method for disulfide analysis of peptides

1975 • 73 citations

Oxidative modification of low density lipoprotein (LDL) by activated human monocytes and the cell lines U937 and HL60

1988 • 71 citations

Formation of sulfhydryl groups in the culture medium by human diploid fibroblasts

1980 • 57 citations

Low density lipoprotein modification by cholesterol oxidase induces enhanced uptake and cholesterol accumulation in cells.

1992 • 52 citations

Regulation of endothelial cell prostaglandin synthesis by glutathione.

1991 • 49 citations

Reduced Repair of Potentially Lethal Radiation Damage in Glutathione Synthetase-deficient Human Fibroblasts after X-irradiation

1985 • 19 citations

Modification of low-density lipoproteins by flavonoids

1990 • 10 citations